Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease von Zuccato, Chiara, Ciammola, Andrea, Rigamonti, Dorotea, Leavitt, Blair R., Goffredo, Donato, Conti, Luciano, MacDonald, Marcy E., Friedlander, Robert M., Silani, Vincenzo, Hayden, Michael R., Timmusk, Tõnis, Sipione, Simonetta, Cattaneo, Elena

Volltext

Minocycline Inhibits Caspase-Independent and -Dependent Mitochondrial Cell Death Pathways in Models of Huntington's Disease von Wang, Xin, Zhu, Shan, Drozda, Martin, Zhang, Wenhua, Stavrovskaya, Irina G., Cattaneo, Elena, Ferrante, Robert J., Kristal, Bruce S., Friedlander, Robert M.

Volltext

Neurotoxicity induces cleavage of p35 to p25 by calpain von Lee, Ming-sum, Kwon, Young T., Li, Mingwei, Peng, Junmin, Friedlander, Robert M., Tsai, Li-Huei

Volltext

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice von ZHU, Shan, STAVROVSKAYA, Irina G, GULLANS, Steven, FERRANTE, Robert J, PRZEDBORSKI, Serge, KRISTAL, Bruce S, FRIEDLANDER, Robert M, DROZDA, Martin, KIM, Betty Y. S, ONA, Victor, MINGWEI LI, SARANG, Satinder, LIU, Allen S, HARTLEY, Dean M, WU, Du Chu

Volltext

Minocycline Inhibits Contusion-Triggered Mitochondrial Cytochrome C Release and Mitigates Functional Deficits after Spinal Cord Injury von Teng, Yang D., Choi, Howard, Onario, Renna C., Zhu, Shan, Desilets, Federico C., Lan, Shoumin, Woodard, Eric J., Snyder, Evan Y., Eichler, Marc E., Friedlander, Robert M., Sidman, Richard L.

Volltext

Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS von Zhang, Wenhua, Narayanan, Malini, Friedlander, Robert M.

Volltext

Fundamental Role of the Rip2/Caspase-1 Pathway in Hypoxia and Ischemia-Induced Neuronal Cell Death von Zhang, Wen-Hua, Wang, Xin, Narayanan, Malini, Zhang, Yu, Huo, Chunfeng, Reed, John C., Friedlander, Robert M.

Volltext

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease von Chen, Minghua, Ona, Victor O., Li, Mingwei, Ferrante, Robert J., Fink, Klaus B., Zhu, Shan, Bian, Jie, Guo, Lei, Farrell, Laurie A., Hersch, Steve M., Hobbs, Wendy, Vonsattel, Jean-Paul, Cha, Jang-Ho J., Friedlander, Robert M.

Volltext

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model von Li, Mingwei, Ona, Victor O., Guégan, Christelle, Chen, Minghua, Jackson-Lewis, Vernice, Andrews, L. John, Olszewski, Adam J., Stieg, Philip E., Jean-Pyo. Lee, Przedborski, Serge, Friedlander, Robert M.

Volltext

Increased generation of granule cells in adult Bcl-2-overexpressing mice: a role for cell death during continued hippocampal neurogenesis von Kuhn, H. Georg, Biebl, Manfred, Wilhelm, Daniel, Li, Mingwei, Friedlander, Robert M., Winkler, Jürgen

Volltext

Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction von Sanchez Mejia, R O, Ona, V O, Li, M, Friedlander, R M

Volltext

Inhibition of Interleukin 1β Converting Enzyme Family Proteases Reduces Ischemic and Excitotoxic Neuronal Damage von Hara, Hideaki, Friedlander, Robert M., Gagliardini, Valeria, Ayata, Cenk, Fink, Klaus, Huang, Zhihong, Shimizu-Sasamata, Masao, Yuan, Junying, Moskowitz, Michael A.

Volltext

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease von Ona, Victor O., Li, Mingwei, Vonsattel, Jean Paul G., Andrews, L. John, Khan, Sohail Q., Chung, Woosik M., Frey, Ariel S., Menon, Anil S., Li, Xiao-Jiang, Stieg, Philip E., Yuan, Junying, Penney, John B., Young, Anne B., Cha, Jang-Ho J., Friedlander, Robert M.

Volltext

Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration von Garden, Gwenn A, Budd, Samantha L, Tsai, Elena, Hanson, Lisa, Kaul, Marcus, D'Emilia, Danielle M, Friedlander, Robert M, Yuan, Junying, Masliah, Eliezer, Lipton, Stuart A

Volltext

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice von Wheeler, Vanessa C., Gutekunst, Claire-Anne, Vrbanac, Vladimir, Lebel, Lori-Anne, Schilling, Gabriele, Hersch, Steven, Friedlander, Robert M., Gusella, James F., Vonsattel, Jean-Paul, Borchelt, David R., MacDonald, Marcy E.

Volltext

Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury von Li, M., Ona, V.O., Chen, M., Kaul, M., Tenneti, L., Zhang, X., Stieg, P.E., Lipton, S.A., Friedlander, R.M.

Volltext

Prophylactic Creatine Administration Mediates Neuroprotection in Cerebral Ischemia in Mice von Zhu, Shan, Li, Mingwei, Figueroa, Bryan E, Liu, Aijian, Stavrovskaya, Irina G, Pasinelli, Piera, Beal, M. Flint, Brown, Robert H., Jr, Kristal, Bruce S, Ferrante, Robert J, Friedlander, Robert M

Volltext

Inhibition of ICE slows ALS in mice von Friedlander, R M, Brown, R H, Gagliardini, V, Wang, J, Yuan, J

Volltext

Depletion of wild‐type huntingtin in mouse models of neurologic diseases von Zhang, Yu, Li, Mingwei, Drozda, Martin, Chen, Minghua, Ren, Shengjun, Mejia Sanchez, Rene O., Leavitt, Blair R., Cattaneo, Elena, Ferrante, Robert J., Hayden, Michael R., Friedlander, Robert M.

Volltext

Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology von Stavrovskaya, Irina G, Narayanan, Malini V, Zhang, Wenhua, Krasnikov, Boris F, Heemskerk, Jill, Young, S Stanley, Blass, John P, Brown, Abraham M, Beal, M Flint, Friedlander, Robert M, Kristal, Bruce S

Volltext