Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies von White, Ann L., Chan, H.T. Claude, French, Ruth R., Willoughby, Jane, Mockridge, C. Ian, Roghanian, Ali, Penfold, Christine A., Booth, Steven G., Dodhy, Ali, Polak, Marta E., Potter, Elizabeth A., Ardern-Jones, Michael R., Verbeek, J. Sjef, Johnson, Peter W.M., Al-Shamkhani, Aymen, Cragg, Mark S., Beers, Stephen A., Glennie, Martin J.

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Mechanisms of killing by anti-CD20 monoclonal antibodies von Glennie, Martin J., French, Ruth R., Cragg, Mark S., Taylor, Ronald P.

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Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy von Lim, Sean H., Vaughan, Andrew T., Ashton-Key, Margaret, Williams, Emily L., Dixon, Sandra V., Chan, H. T. Claude, Beers, Stephen A., French, Ruth R., Cox, Kerry L., Davies, Andrew J., Potter, Kathleen N., Mockridge, C. Ian, Oscier, David G., Johnson, Peter W.M., Cragg, Mark S., Glennie, Martin J.

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Anti-CD20 monoclonal antibodies: historical and future perspectives von LIM, Sean H, BEERS, Stephen A, FRENCH, Ruth R, JOHNSON, Peter W. M, GLENNIE, Martin J, CRAGG, Mark S

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Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection von Beers, Stephen A., French, Ruth R., Chan, H.T. Claude, Lim, Sean H., Jarrett, Timothy C., Vidal, Regina Mora, Wijayaweera, Sahan S., Dixon, Sandra V., Kim, Hyungjin, Cox, Kerry L., Kerr, Jonathan P., Johnston, David A., Johnson, Peter W.M., Verbeek, J. Sjef, Glennie, Martin J., Cragg, Mark S.

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CD20 as a Target for Therapeutic Type I and II Monoclonal Antibodies von Beers, Stephen A, Chan, Claude H.T, French, Ruth R, Cragg, Mark S, Glennie, Martin J

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The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20 von Teeling, Jessica L, Mackus, Wendy J. M, Wiegman, Luus J. J. M, van den Brakel, Jeroen H. N, Beers, Stephen A, French, Ruth R, van Meerten, Tom, Ebeling, Saskia, Vink, Tom, Slootstra, Jerry W, Parren, Paul W. H. I, Glennie, Martin J, van de Winkel, Jan G. J

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Induction of Cytosolic Calcium Flux by CD20 Is Dependent upon B Cell Antigen Receptor Signaling von Walshe, Claire A., Beers, Stephen A., French, Ruth R., Chan, Claude H.T., Johnson, Peter W., Packham, Graham K., Glennie, Martin J., Cragg, Mark S.

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TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity von Yu, Xiaojie, James, Sonya, Felce, James H., Kellermayer, Blanka, Johnston, David A., Chan, H. T. Claude, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, Watanabe, Yasunori, Crispin, Max, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., Glennie, Martin J., Cragg, Mark S.

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CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses von Castro, Fernanda V.V, Tutt, Alison L, White, Ann L, Teeling, Jessica L, James, Sonya, French, Ruth R, Glennie, Martin J

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On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation von Sopp, Joshua M., Peters, Shirley J., Rowley, Tania F., Oldham, Robert J., James, Sonya, Mockridge, Ian, French, Ruth R., Turner, Alison, Beers, Stephen A., Humphreys, David P., Cragg, Mark S.

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Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity von Yu, Xiaojie, Chan, H.T. Claude, Fisher, Hayden, Penfold, Christine A., Kim, Jinny, Inzhelevskaya, Tatyana, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick J., Douglas, Leon R., English, Vikki, Verbeek, J. Sjef, White, Ann L., Tews, Ivo, Glennie, Martin J., Cragg, Mark S.

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Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies von Yu, Xiaojie, Chan, H.T. Claude, Orr, Christian M., Dadas, Osman, Booth, Steven G., Dahal, Lekh N., Penfold, Christine A., O'Brien, Lyn, Mockridge, C. Ian, French, Ruth R., Duriez, Patrick, Douglas, Leon R., Pearson, Arwen R., Cragg, Mark S., Tews, Ivo, Glennie, Martin J., White, Ann L.

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OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential von Lai, Chester, August, Suzannah, Albibas, Amel, Behar, Ramnik, Cho, Shin-Young, Polak, Marta E, Theaker, Jeffrey, MacLeod, Amanda S, French, Ruth R, Glennie, Martin J, Al-Shamkhani, Aymen, Healy, Eugene

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Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody von White, Ann L, Chan, H T Claude, Roghanian, Ali, French, Ruth R, Mockridge, C Ian, Tutt, Alison L, Dixon, Sandra V, Ajona, Daniel, Verbeek, J Sjef, Al-Shamkhani, Aymen, Cragg, Mark S, Beers, Stephen A, Glennie, Martin J

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Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies von Tipton, Thomas R.W., Roghanian, Ali, Oldham, Robert J., Carter, Matthew J., Cox, Kerry L., Mockridge, C. Ian, French, Ruth R., Dahal, Lekh N., Duriez, Patrick J., Hargreaves, Philip G., Cragg, Mark S., Beers, Stephen A.

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Effector mechanisms of IgA antibodies against CD20 include recruitment of myeloid cells for antibody‐dependent cell‐mediated cytotoxicity and complement‐dependent cytotoxicity... von Lohse, Stefan, Loew, Sebastian, Kretschmer, Anna, Jansen, J. H. Marco, Meyer, Saskia, ten Broeke, Toine, Rösner, Thies, Dechant, Michael, Derer, Stefanie, Klausz, Katja, Kellner, Christian, Schwanbeck, Ralf, French, Ruth R., Tipton, Thomas R. W., Cragg, Mark S., Schewe, Denis M., Peipp, Matthias, Leusen, Jeanette H. W., Valerius, Thomas

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Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation von Beers, Stephen A., Chan, Claude H.T., James, Sonya, French, Ruth R., Attfield, Kathrine E., Brennan, Claire M., Ahuja, Anupama, Shlomchik, Mark J., Cragg, Mark S., Glennie, Martin J.

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Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking von Turaj, Anna H., Cox, Kerry L., Penfold, Christine A., French, Ruth R., Mockridge, C. Ian, Willoughby, Jane E., Tutt, Alison L., Griffiths, Jordana, Johnson, Peter W. M., Glennie, Martin J., Levy, Ronald, Cragg, Mark S., Lim, Sean H.

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Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412 von Hussain, Khiyam, Hargreaves, Chantal E., Roghanian, Ali, Oldham, Robert J., Chan, H. T. Claude, Mockridge, C. Ian, Chowdhury, Ferdousi, Frendéus, Bjorn, Harper, Kirsty S., Strefford, Jonathan C., Cragg, Mark S., Glennie, Martin J., Williams, Anthony P., French, Ruth R.

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