Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome von Puente, Xose S., Quesada, Victor, Osorio, Fernando G., Cabanillas, Rubén, Cadiñanos, Juan, Fraile, Julia M., Ordóñez, Gonzalo R., Puente, Diana A., Gutiérrez-Fernández, Ana, Fanjul-Fernández, Miriam, Lévy, Nicolas, Freije, José M.P., López-Otín, Carlos

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Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice von Cadiñanos, Juan, Rodríguez, Francisco, Wang, Jianming, Wernerson, Annika, Pendás, Alberto M, Tryggvason, Karl, Astudillo, Aurora, Zhou, Zhongjun, Freije, José M.P, López-Otín, Carlos, Hultenby, Kjell

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Nuclear envelope defects cause stem cell dysfunction in premature-aging mice von Espada, Jesús, Varela, Ignacio, Flores, Ignacio, Ugalde, Alejandro P, Cadiñanos, Juan, Pendás, Alberto M, Stewart, Colin L, Tryggvason, Karl, Blasco, María A, Freije, José M.P, López-Otín, Carlos

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Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism von Bárcena, Clea, Quirós, Pedro M., Durand, Sylvère, Mayoral, Pablo, Rodríguez, Francisco, Caravia, Xurde M., Mariño, Guillermo, Garabaya, Cecilia, Fernández-García, María Teresa, Kroemer, Guido, Freije, José M.P., López-Otín, Carlos

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Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells von Garrido, Pablo, Osorio, Fernando G., Morán, Javier, Cabello, Estefanía, Alonso, Ana, Freije, José M.P., González, Celestino

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Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion von de la Rosa, Jorge, Freije, José M.P., Cabanillas, Rubén, Osorio, Fernando G., Fraga, Mario F., Fernández-García, M. Soledad, Rad, Roland, Fanjul, Víctor, Ugalde, Alejandro P., Liang, Qi, Prosser, Haydn M., Bradley, Allan, Cadiñanos, Juan, López-Otín, Carlos

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Premature aging in mice activates a systemic metabolic response involving autophagy induction von Mariño, Guillermo, Ugalde, Alejandro P., Salvador-Montoliu, Natalia, Varela, Ignacio, Quirós, Pedro M., Cadiñanos, Juan, van der Pluijm, Ingrid, Freije, José M.P., López-Otín, Carlos

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Loss of ADAM29 does not affect viability and fertility in mice but improves wound healing von Campos-Iglesias, Diana, Montero, Alejandro A., Rodríguez, Francisco, López-Otín, Carlos, Freije, José M.P.

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Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells von Alvarez-Díaz, Silvia, Valle, Noelia, García, José Miguel, Peña, Cristina, Freije, José M P, Quesada, Víctor, Astudillo, Aurora, Bonilla, Félix, López-Otín, Carlos, Muñoz, Alberto

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The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis von Fraile, Julia M., Campos-Iglesias, Diana, Rodríguez, Francisco, Español, Yaiza, Freije, José M.P.

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Lamins, guardians of the soma and the genome von Freije, José M.P., Pendás, Alberto M.

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NF-κB activation impairs somatic cell reprogramming in ageing von Soria-Valles, Clara, Osorio, Fernando G., Gutiérrez-Fernández, Ana, De Los Angeles, Alejandro, Bueno, Clara, Menéndez, Pablo, Martín-Subero, José I., Daley, George Q., Freije, José M. P., López-Otín, Carlos

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Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype von Lee, Su-Jin, Jung, Youn-Sang, Yoon, Min-Ho, Kang, So-Mi, Oh, Ah-Young, Lee, Jee-Hyun, Jun, So-Young, Woo, Tae-Gyun, Chun, Ho-Young, Kim, Sang Kyum, Chung, Kyu Jin, Lee, Ho-Young, Lee, Kyeong, Jin, Guanghai, Na, Min-Kyun, Ha, Nam Chul, Bárcena, Clea, Freije, José M P, López-Otín, Carlos, Song, Gyu Yong, Park, Bum-Joon

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Metabolic Control of Longevity von López-Otín, Carlos, Galluzzi, Lorenzo, Freije, José M.P., Madeo, Frank, Kroemer, Guido

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From Immature Lamin to Premature Aging: Molecular Pathways and Therapeutic Opportunities von Cadiñanos, Juan, Varela, Ignacio, López-Otín, Carlos, Freije, José M.P.

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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging von Varela, Ignacio, Osorio, Fernando G, Cobo, Juan, Suárez, María F, Freije, José M P, López-Otín, Carlos, Pereira, Sandrine, Cadiñanos, Juan, Ugalde, Alejandro P, de Carlos, Félix, Navarro, Claire L, Foray, Nicolas, Cau, Pierre, Lévy, Nicolas

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Autophagy is essential for mouse sense of balance von Mariño, Guillermo, Fernández, Alvaro F, Cabrera, Sandra, Lundberg, Yunxia W, Cabanillas, Rubén, Rodríguez, Francisco, Salvador-Montoliu, Natalia, Vega, José A, Germanà, Antonino, Fueyo, Antonio, Freije, José M P, López-Otín, Carlos

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Collagenase-3 Binds to a Specific Receptor and Requires the Low Density Lipoprotein Receptor-related Protein for Internalization von Barmina, Olga Y., Walling, Hobart W., Fiacco, Gerald J., Freije, José M.P., López-Otı́n, Carlos, Jeffrey, John J., Partridge, Nicola C.

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Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice von Bárcena, Clea, Valdés-Mas, Rafael, Mayoral, Pablo, Garabaya, Cecilia, Durand, Sylvère, Rodríguez, Francisco, Fernández-García, María Teresa, Salazar, Nuria, Nogacka, Alicja M., Garatachea, Nuria, Bossut, Noélie, Aprahamian, Fanny, Lucia, Alejandro, Kroemer, Guido, Freije, José M. P., Quirós, Pedro M., López-Otín, Carlos

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Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling von Osorio, Fernando G, Soria-Valles, Clara, Santiago-Fernández, Olaya, Bernal, Teresa, Mittelbrunn, María, Colado, Enrique, Rodríguez, Francisco, Bonzon-Kulichenko, Elena, Vázquez, Jesús, Porta-de-la-Riva, Montserrat, Cerón, Julián, Fueyo, Antonio, Li, Juan, Green, Anthony R, Freije, José M P, López-Otín, Carlos

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