Genomic inflation factors under polygenic inheritance von JIAN YANG, WEEDON, Michael N, MÄGI, Reedik, MADDEN, Pamela A, HEATH, Andrew C, NYHOLT, Dale R, MARTIN, Nicholas G, MONTGOMERY, Grant W, FRAYLING, Timothy M, HIRSCHHORN, Joel N, MCCARTHY, Mark I, GODDARD, Michael E, PURCELL, Shaun, VISSCHER, Peter M, LETTRE, Guillaume, ESTRADA, Karol, WILLER, Cristen J, SMITH, Albert V, INGELSSON, Erik, O'CONNELL, Jeffrey R, MANGINO, Massimo

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Young-Onset Type 2 Diabetes Families Are the Major Contributors to Genetic Loci in the Diabetes UK Warren 2 Genome Scan and Identify Putative Novel Loci on Chromosomes 8q21, 21q22,... von FRAYLING, Timothy M, WILTSHIRE, Steven, HITMAN, Graham A, WALKER, Mark, LEVY, Jonathan C, SAMPSON, Mike, GROVES, Christopher J, MENZEL, Stephan, MCCARTHY, Mark I, HATTERSLEY, Andrew T

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Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes von Gloyn, Anna L, Pearson, Ewan R, Antcliff, Jennifer F, Proks, Peter, Bruining, G. Jan, Slingerland, Annabelle S, Howard, Neville, Srinivasan, Shubha, Silva, José M.C.L, Molnes, Janne, Edghill, Emma L, Frayling, Timothy M, Temple, I. Karen, Mackay, Deborah, Shield, Julian P.H, Sumnik, Zdenek, van Rhijn, Adrian, Wales, Jerry K.H, Clark, Penelope, Gorman, Shaun, Aisenberg, Javier, Ellard, Sian, Njølstad, Pål R, Ashcroft, Frances M, Hattersley, Andrew T

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Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants von Pilling, Luke C, Atkins, Janice L, Bowman, Kirsty, Jones, Samuel E, Tyrrell, Jessica, Beaumont, Robin N, Ruth, Katherine S, Tuke, Marcus A, Yaghootkar, Hanieh, Wood, Andrew R, Freathy, Rachel M, Murray, Anna, Weedon, Michael N, Xue, Luting, Lunetta, Kathryn, Murabito, Joanne M, Harries, Lorna W, Robine, Jean-Marie, Brayne, Carol, Kuchel, George A, Ferrucci, Luigi, Frayling, Timothy M, Melzer, David

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Genome-wide association studies: the good, the bad and the ugly von Frayling, TM

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A common variant of the interleukin 6 receptor ( ) gene increases IL-6r and IL-6 levels, without other inflammatory effects von Rafiq, S, Frayling, T M, Murray, A, Hurst, A, Stevens, K, Weedon, M N, Henley, W, Ferrucci, L, Bandinelli, S, Corsi, A-M, Guralnik, J M, Melzer, D

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Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank von Howe, LD, Kanayalal, R, Harrison, S, Beaumont, RN, Davies, AR, Frayling, TM, Davies, NM, Hughes, A, Jones, SE, Sassi, F, Wood, AR, Tyrrell, J

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Mutations in the human Delta homologue, DLL3 , cause axial skeletal defects in spondylocostal dysostosis von Bulman, Michael P, Hattersley, Andrew T, Kusumi, Kenro, Turnpenny, Peter D, Frayling, Timothy M, Lander, Eric S, Ellard, Sian, Krumlauf, Robb, McKeown, Carole, Garrett, Christine

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beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors von FRAYLING, Timothy M, EVANS, Julie C, HATTERSLEY, Andrew T, BULMAN, Michael P, PEARSON, Ewan, ALLEN, Lisa, OWEN, Katharine, BINGHAM, Coralie, HANNEMANN, Michael, SHEPHERD, Maggie, ELLARD, Sian

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A Genomewide Scan for Loci Predisposing to Type 2 Diabetes in a U.K. Population (The Diabetes UK Warren 2 Repository): Analysis of 573 Pedigrees Provides Independent Replication of... von Wiltshire, Steven, Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Levy, Jonathan C., Sampson, Michael, O’Rahilly, Stephen, Frayling, Timothy M., Bell, John I., Lathrop, G. Mark, Bennett, Amanda, Dhillon, Ranjit, Fletcher, Christopher, Groves, Christopher J., Jones, Elizabeth, Prestwich, Philip, Simecek, Nikol, Rao, Pamidighantam V. Subba, Wishart, Marie, Foxon, Richard, Howell, Simon, Smedley, Damian, Cardon, Lon R., Menzel, Stephan, McCarthy, Mark I.

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Meta-Analysis and a Large Association Study Confirm a Role for Calpain-10 Variation in Type 2 Diabetes Susceptibility von Weedon, Michael N., Schwarz, Peter E.H., Horikawa, Yukio, Iwasaki, Naoko, Illig, Thomas, Holle, Rolf, Rathmann, Wolfgang, Selisko, Thomas, Schulze, Jan, Owen, Katherine R., Evans, Julie, del Bosque-Plata, Laura, Hitman, Graham, Walker, Mark, Levy, Jonathan C., Sampson, Mike, Bell, Graeme I., McCarthy, Mark I., Hattersley, Andrew T., Frayling, Timothy M.

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Genome-wide and abdominal MRI data provide evidence that a genetically determined favorable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2... von Ji, Y, Yiorkas, AM, Frau, F, Mook-Kanamori, D, Staiger, H, Thomas, EL, Atabaki-Pasdar, N, Campbell, A, Tyrrell, J, Jones, SE, Beaumont, RN, Wood, AR, Tuke, MA, Ruth, KS, Mahajan, A, Murray, A, Freathy, RM, Weedon, MN, Hattersley, AT, Hayward, C, Machann, J, Haering, H-U, Franks, P, De Mutsert, R, Pearson, E, Stefan, N, Frayling, TM, Allebrandt, KV, Bell, JD, Blakemore, AI, Yaghootkar, H

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A distant upstream promoter of the HNF-4α gene connects the transcription factors involved in maturity-onset diabetes of the young von THOMAS, Heike, JASCHKOWITZ, Karin, HATTERSLEY, Andrew T, BULMAN, Mike, FRAYLING, Timothy M, MITCHELL, Simon M. S, ROOSEN, Simone, LINGOTT-FRIEG, Anja, TACK, Cees J, ELLARD, Sian, RYFFEL, Gerhart U

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Rare and low-frequency coding variants alter human adult height von Marouli, E, Graff, M, Medina-Gomez, C, Lo, KS, Wood, AR, Kjaer, TR, Fine, RS, Lu, Y, Elliott, P, Chambers, JC, Evangelou, E, Kooner, JS, Oxvig, C, Kutalik, Z, Rivadeneira, F, Loos, RJF, Frayling, TM, Hirschorn, JS, Deloukas, P, Lettre, G

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Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United Kingdom von Evans, Julie C., Frayling, Timothy M., Cassell, Paul G., Saker, Philip J., Hitman, Graham A., Walker, Mark, Levy, Jonathan C., O’Rahilly, Stephen, Rao, Pamidighantam V. Subba, Bennett, Amanda J., Jones, Elizabeth C., Menzel, Stephan, Prestwich, Philip, Simecek, Nikol, Wishart, Marie, Dhillon, Ranjit, Fletcher, Chris, Millward, Ann, Demaine, Andrew, Wilkin, Terence, Horikawa, Yukio, Cox, Nancy J., Bell, Graeme I., Ellard, Sian, McCarthy, Mark I., Hattersley, Andrew T.

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Intrauterine Hyperglycemia Is Associated With an Earlier Diagnosis of Diabetes in HNF-1α Gene Mutation Carriers von STRIDE, Amanda, SHEPHERD, Maggie, FRAYLING, Timothy M, BULMAN, Mike P, ELLARD, Sian, HATTERSLEY, Andrew T

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Common Variants of the Hepatocyte Nuclear Factor-4α P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population von WEEDON, Michael N, OWEN, Katharine R, SHIELDS, Beverley, HITMAN, Graham, WALKER, Mark, MCCARTHY, Mark I, LOVE-GREGORY, Latisha D, PERMUTT, M. Alan, HATTERSLEY, Andrew T, FRAYLING, Timothy M

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Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene von WEEDON, Michael N, FRAYLING, Timothy M, SMITH, George Davey, RING, Sue, JONES, Richard, GOLDING, Jean, BYBERG, Liisa, MANN, Vera, AXELSSON, Tomas, SYVÄNEN, Ann-Christine, LEON, David, HATTERSLEY, Andrew T, SHIELDS, Beverley, KNIGHT, Beatrice, TURNER, Tina, METCALF, Bradley S, VOSS, Linda, WILKIN, Terence J, MCCARTHY, Anne, BEN-SHLOMO, Yoav

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Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes von Macfarlane, W M, Frayling, T M, Ellard, S, Evans, J C, Allen, L I, Bulman, M P, Ayres, S, Shepherd, M, Clark, P, Millward, A, Demaine, A, Wilkin, T, Docherty, K, Hattersley, A T

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A putative functional polymorphism in the IGF-I gene: Association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations von FRAYLING, Timothy M, HATTERSLEY, Andrew T, MCCARTHY, Anne, HOLLY, Jeff, MITCHELL, Simon M. S, GLOYN, Anna L, OWEN, Katharine, DAVIES, David, SMITH, George Davey, BEN-SHLOMO, Yoav

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