Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance von McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Wong, Ellis W.T., Chang, Fumin, Lehmann, Brian, Terrian, David M., Milella, Michele, Tafuri, Agostino, Stivala, Franca, Libra, Massimo, Basecke, Jorg, Evangelisti, Camilla, Martelli, Alberto M., Franklin, Richard A.

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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance von McCubrey, James A, Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Franklin, Richard A, Montalto, Giuseppe, Cervello, Melchiorre, Libra, Massimo, Candido, Saverio, Malaponte, Grazia, Mazzarino, Maria C, Fagone, Paolo, Nicoletti, Ferdinando, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Milella, Michele, Tafuri, Agostino, Chiarini, Francesca, Evangelisti, Camilla, Cocco, Lucio, Martelli, Alberto M

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Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells von Steelman, Linda S., Navolanic, Patrick, Chappell, William H., Abrams, Stephen L., Wong, Ellis W.T., Martelli, Alberto M., Cocco, Lucio, Stivala, Franca, Libra, Massimo, Nicoletti, Ferdinando, Drobot, Lyudmyla B., Franklin, Richard A., McCubrey, James A.

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Redox Regulation of the Calcium/Calmodulin-dependent Protein Kinases von Howe, Christopher J, Lahair, Michelle M, McCubrey, James A, Franklin, Richard A

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EGF Induces Cell Motility and Multi-Drug Resistance Gene Expression in Breast Cancer Cells von Garcia, Ruben, Franklin, Richard A., McCubrey, James A.

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Advances in targeting signal transduction pathways von McCubrey, James A, Steelman, Linda S, Chappell, William H, Sun, Lin, Davis, Nicole M, Abrams, Stephen L, Franklin, Richard A, Cocco, Lucio, Evangelisti, Camilla, Chiarini, Francesca, Martelli, Alberto M, Libra, Massimo, Candido, Saverio, Ligresti, Giovanni, Malaponte, Grazia, Mazzarino, Maria C, Fagone, Paolo, Donia, Marco, Nicoletti, Ferdinando, Polesel, Jerry, Talamini, Renato, Bäsecke, Jörg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Michele, Michele, Tafuri, Agostino, Dulińska-Litewka, Joanna, Laidler, Piotr, D'Assoro, Antonio B, Drobot, Lyudmyla, Umezawa, Drobot, Montalto, Giuseppe, Cervello, Melchiorre, Demidenko, Zoya N

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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health von Chappell, William H, Steelman, Linda S, Long, Jacquelyn M, Kempf, Ruth C, Abrams, Stephen L, Franklin, Richard A, Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Mazzarino, Maria C, Nicoletti, Ferdinando, Libra, Massimo, Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Montalto, Giuseppe, Cervello, Melchiorre, Laidler, Piotr, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Evangelisti, Camilla, Cocco, Lucio, Martelli, Alberto M, McCubrey, James A

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Effects of the RAF MEK ERK and PI3K AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells von SHELTON, John G, STEELMAN, Linda S, MCCUBREY, James A, LEE, John T, KNAPP, Steven L, BLALOCK, William L, MOYE, Phillip W, FRANKLIN, Richard A, POHNERT, Steven C, MIRZA, Amer M, MCMAHON, Martin

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OSU-03012 in the Treatment of Glioblastoma von McCubrey, James A, Lahair, Michelle M, Franklin, Richard A

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Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibi... von McCubrey, James A, Meher, Akshaya K, Akula, Shaw M, Abrams, Stephen L, Steelman, Linda S, LaHair, Michelle M, Franklin, Richard A, Martelli, Alberto M, Ratti, Stefano, Cocco, Lucio, Barbaro, Fulvio, Duda, Przemysław, Gizak, Agnieszka

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17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines von Mitchell, Clint, Park, Margaret A, Zhang, Guo, Han, Song Iy, Harada, Hisashi, Franklin, Richard A, Yacoub, Adly, Li, Pin-Lan, Hylemon, Philip B, Grant, Steven, Dent, Paul

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Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin von Weinstein-Oppenheimer, C R, Henríquez-Roldán, C F, Davis, J M, Navolanic, P M, Saleh, O A, Steelman, L S, Franklin, R A, Robinson, P J, McMahon, M, McCubrey, J A

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A multipronged approach to prostate cancer von Franklin, Richard A., McCubrey, James A.

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Inhibition of the CaM-Kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells von Rodriguez-Mora, Oswaldo, LaHair, Michelle M., Evans, Mark J., Kovacs, Charles J., Allison, Ron R., Sibata, Claudio H., White, Kawana S., McCubrey, James A., Franklin, Richard A.

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Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy von Sokolosky, Melissa L, Stadelman, Kristin M, Chappell, William H, Abrams, Stephen L, Martelli, Alberto M, Stivala, Franca, Libra, Massimo, Nicoletti, Ferdinando, Drobot, Lyudmyla B, Franklin, Richard A, Steelman, Linda S, McCubrey, James A

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Polyphenols in breast cancer treatment von Franklin, Richard A., McCubrey, James A.

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Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines von Shelton, John G., Steelman, Linda S., Abrams, Steven L., White, Edmund R., Akula, Shaw M., Franklin, Richard A., Bertrand, Fred E., McMahon, Martin, McCubrey, James A

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Child Injury and the Determinants of Health

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Effects of Endogenous Epidermal Growth Factor Receptor Signaling on DNA Synthesis and ERK Activation in a Cytokine-Dependent Hematopoietic Cell Line von Shelton, John G., Steelman, Linda S., Abrams, Steven L., White, Edmund R., Akula, Shaw M., Bertrand, Fred E., Franklin, Richard A., McCubrey, James A

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Cell Death of MCF-7 Human Breast Cancer Cells Induced by EGFR Activation in the Absence of Other Growth Factors von Garcia, Ruben, Franklin, Richard A, McCubrey, James A

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