Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities von Paassen, Irene, Williams, Justin, Ríos Arceo, Carla, Ringnalda, Femke, Mercer, Kimberly Shea, Buhl, Juliane L., Moreno, Natalia, Federico, Aniello, Franke, Niels E., Kranendonk, Mariette, Upadhyaya, Santhosh A., Kerl, Kornelius, van de Wetering, Marc, Clevers, Hans, Kool, Marcel, Hoving, Eelco W., Roussel, Martine F., Drost, Jarno

Volltext

(Immuno)proteasomes as therapeutic target in acute leukemia von Cloos, Jacqueline, Roeten, Margot SF, Franke, Niels E, van Meerloo, Johan, Zweegman, Sonja, Kaspers, Gertjan JL, Jansen, Gerrit

Volltext

Higher ratio immune versus constitutive proteasome level as novel indicator of sensitivity of pediatric acute leukemia cells to proteasome inhibitors von Niewerth, Denise, Franke, Niels E, Jansen, Gerrit, Assaraf, Yehuda G, van Meerloo, Johan, Kirk, Christopher J, Degenhardt, Jeremiah, Anderl, Janet, Schimmer, Aaron D, Zweegman, Sonja, de Haas, Valerie, Horton, Terzah M, Kaspers, Gertjan J L, Cloos, Jacqueline

Volltext

Ophthalmological Findings in Youths With a Newly Diagnosed Brain Tumor von Nuijts, Myrthe A, Stegeman, Inge, van Seeters, Tom, Borst, Marloes D, Bennebroek, Carlien A. M, Buis, Dennis R, Naus, Nicole C, Porro, Giorgio L, van Egmond-Ebbeling, Michelle B, Voskuil-Kerkhof, Elisabeth S. M, Pott, JanWillem R, Franke, Niels E, de Vos-Kerkhof, Evelien, Hoving, Eelco W, Schouten-van Meeteren, Antoinette Y. N, Imhof, Saskia M

Volltext

Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors von Metselaar, Dennis S., Meel, Michaël H., Goulding, Joshua R., du Chatinier, Aimeé, Rigamonti, Leyla, Waranecki, Piotr, Geisemeyer, Neal, de Gooijer, Mark C., Breur, Marjolein, Koster, Jan, Veldhuijzen van Zanten, Sophie E.M., Bugiani, Marianna, Franke, Niels E., Reddy, Alyssa, Wesseling, Pieter, Kaspers, Gertjan J.L., Hulleman, Esther

Volltext

Effect of Noncompetitive Proteasome Inhibition on Bortezomib Resistance von Li, Xiaoming, Wood, Tabitha E., Sprangers, Remco, Jansen, Gerrit, Franke, Niels E., Mao, Xinliang, Wang, Xiaoming, Zhang, Yi, Verbrugge, Sue Ellen, Adomat, Hans, Li, Zhi Hua, Trudel, Suzanne, Chen, Christine, Religa, Tomasz L., Jamal, Nazir, Messner, Hans, Cloos, Jacqueline, Rose, David R., Navon, Ami, Guns, Emma, Batey, Robert A., Kay, Lewis E., Schimmer, Aaron D.

Volltext

Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors von Franke, Niels E, Kaspers, Gertjan L, Assaraf, Yehuda G, van Meerloo, Johan, Niewerth, Denise, Kessler, Floortje L, Poddighe, Pino J, Kole, Jeroen, Smeets, Serge J, Ylstra, Bauke, Bi, Chonglei, Chng, Wee Joo, Horton, Terzah M, Menezes, Rene X, Musters, Renée J P, Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline

Volltext

LacdiNAc-Glycans Constitute a Parasite Pattern for Galectin-3-Mediated Immune Recognition von van den Berg, Timo K, Honing, Henk, Franke, Niels, van Remoortere, Alexandra, Schiphorst, Wietske E. C. M, Liu, Fu-Tong, Deelder, Andre M, Cummings, Richard D, Hokke, Cornelis H, van Die, Irma

Volltext

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype von Beumer, Jan-Hendrik, Buckle, Tessa, Ouwehand, Mariet, Franke, Niels E F, Lopez-Lazaro, Luis, Schellens, Jan H M, Beijnen, Jos H, van Tellingen, Olaf

Volltext

A new link between steroid resistance, glucocorticoid receptor and nuclear factor kappa B p65 in idiopathic nephrotic syndrome von Szilagyi, Katarina, Podracka, Ludmila, Franke, Niels E, Mojzis, Jan, Mirossay, Ladislav

Volltext

Molecular basis of bortezomib resistance: proteasome subunit β5 (PSMB5) gene mutation and overexpression of PSMB5 protein von Oerlemans, Ruud, Franke, Niels E., Assaraf, Yehuda G., Cloos, Jacqueline, van Zantwijk, Ina, Berkers, Celia R., Scheffer, George L., Debipersad, Kabir, Vojtekova, Katharina, Lemos, Clara, van der Heijden, Joost W., Ylstra, Bauke, Peters, Godefridus J., Kaspers, Gertjan L., Dijkmans, Ben A.C., Scheper, Rik J., Jansen, Gerrit

Volltext

Marcks Marks Resistance to Proteasome Inhibitors: Exocytosis of Polyubiquitinated Proteins in Bortezomib-Resistant Leukemia Cells von Franke, Niels, Kaspers, Gertjan J.L., Assaraf, Yehuda G, Van Meerloo, Johan, Niewerth, Denise, Horton, Terzah M., Chng, Wee Joo, Bi, Chonglei, Menezes, Rene X., Musters, Renée J., Poddighe, Pino J., Kessler, Floortje, Smeets, Serge, Ylstra, Bauke, Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline

Volltext

Interferon-γ-Induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance of Leukemia Cell Lines Harbouring Bortezomib-Induced Mutations in Constitutiv... von Niewerth, Denise, Franke, Niels, Jansen, Gerrit, Assaraf, Yehuda, van Meerloo, Johan, Kirk, Christopher J, Zweegman, Sonja, Kaspers, Gertjan J.L., Cloos, Jacqueline

Volltext

Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression von Niewerth, Denise, Franke, Niels, Jansen, Gerrit, van Meerloo, Johan, Assaraf, Yehuda, Kirk, Christopher J, Chan, Elena T, Zweegman, Sonja, Kaspers, Gertjan J., Cloos, Jacqueline

Volltext

Abstract A27: Chronic exposure of malignant hematological cell lines to bortezomib induces de novo hot spot mutations in the PSMB5 gene von Franke, Niels, Niewerth, Denise, van Meerloo, Johan, Vojtekova, Katarina, Verbrugge, Sue Ellen, Schimmer, Aaron, Kaspers, Gertjan, Jansen, Gerrit, Cloos, Jacqueline

Volltext

Acquisition of Mutations in the PSMB5 Gene during Chronic Exposure of Human Acute Lymphoblastic Leukemia CCRF-CEM Cells to the Proteasome Inhibitor Bortezomib von Franke, Niels E, Oerlemans, Ruud, van Zantwijk, Ina, Vojtekova, Katarina, Kaspers, Gertjan L, Jansen, Gerrit, Cloos, Jacqueline

Volltext

The Novel Proteasome Inhibitor 5-Amino-8-Hydroxyquinole (5AHQ) Overcomes Bortezomib Resistance in Malignant Hematological Cell Line Models Harboring Mutations in the PSMB5 Gene von Franke, Niels E, van Meerloo, Johan, Slot, Linda, Li, Xiaoming, Wood, Tabitha E, Vojtekova, Katarina, Verbrugge, Sue Ellen, Kaspers, Gertjan, Batey, Robert A., Schimmer, Aaron D., Jansen, Gerrit, Cloos, Jacqueline

Volltext

Acquired Resistance to Bortezomib in Human RPMI-8226 Multiple Myeloma Cells: Molecular Characterization, Cross-Resistance with Other Proteasome Inhibitors but Marked Sensitization... von Franke, Niels E, Kaspers, Gertjan L, van den Berg, Nynke, van Zantwijk, Ina, Vojtekova, Katarina, Yaqub, Uzma, Smeets, Serge, Ylstra, Bauke, Zweegman, Sonja, Jansen, Gerrit, Cloos, Jacqueline

Volltext

Molecular Mechanisms of Bortezomib Resistance in Acute Lymphoblastic Leukemia Cells in Comparison with Multiple Myeloma Cells von Franke, Niels E., Oerlemans, Ruud, Zweegman, Sonja, van Zantwijk, Ina, Kaspers, Gertjan J., Jansen, Gerrit, Cloos, Jacqueline

Volltext

Ex Vivo Activity of Bortezomib and Dexamethasone Combinations Against Childhood Acute Leukemia Cells von Franke, Niels E., van Zantwijk, Ina, Kaspers, Gertjan J., Vink, Josefien, Reinhardt, Dirk, Jansen, Gerrit, Cloos, Jacqueline

Volltext