Gene co-expression analysis for functional classification and gene-disease predictions von van Dam, Sipko, Võsa, Urmo, van der Graaf, Adriaan, Franke, Lude, de Magalhães, João Pedro

Volltext

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics von Giambartolomei, Claudia, Vukcevic, Damjan, Schadt, Eric E, Franke, Lude, Hingorani, Aroon D, Wallace, Chris, Plagnol, Vincent

Volltext

Relationship between gut microbiota and circulating metabolites in population-based cohorts von Vojinovic, Dina, Radjabzadeh, Djawad, Kurilshikov, Alexander, Amin, Najaf, Wijmenga, Cisca, Franke, Lude, Ikram, M. Arfan, Uitterlinden, Andre G., Zhernakova, Alexandra, Fu, Jingyuan, Kraaij, Robert, van Duijn, Cornelia M.

Volltext

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases von Sanna, Serena, van Zuydam, Natalie R., Mahajan, Anubha, Kurilshikov, Alexander, Vich Vila, Arnau, Võsa, Urmo, Mujagic, Zlatan, Masclee, Ad A. M., Jonkers, Daisy M. A. E., Oosting, Marije, Joosten, Leo A. B., Netea, Mihai G., Franke, Lude, Zhernakova, Alexandra, Fu, Jingyuan, Wijmenga, Cisca, McCarthy, Mark I.

Volltext

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease von Imhann, Floris, Vich Vila, Arnau, Bonder, Marc Jan, Fu, Jingyuan, Gevers, Dirk, Visschedijk, Marijn C, Spekhorst, Lieke M, Alberts, Rudi, Franke, Lude, van Dullemen, Hendrik M, Ter Steege, Rinze W F, Huttenhower, Curtis, Dijkstra, Gerard, Xavier, Ramnik J, Festen, Eleonora A M, Wijmenga, Cisca, Zhernakova, Alexandra, Weersma, Rinse K

Volltext

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity von Zhernakova, Alexandra, Kurilshikov, Alexander, Bonder, Marc Jan, Tigchelaar, Ettje F., Schirmer, Melanie, Vatanen, Tommi, Mujagic, Zlatan, Vila, Arnau Vich, Falony, Gwen, Vieira-Silva, Sara, Wang, Jun, Imhann, Floris, Brandsma, Eelke, Jankipersadsing, Soesma A., Joossens, Marie, Cenit, Maria Carmen, Deelen, Patrick, Swertz, Morris A., study, LifeLines cohort, Weersma, Rinse K., Feskens, Edith J. M., Netea, Mihai G., Gevers, Dirk, Jonkers, Daisy, Franke, Lude, Aulchenko, Yurii S., Huttenhower, Curtis, Raes, Jeroen, Hofker, Marten H., Xavier, Ramnik J., Wijmenga, Cisca, Fu, Jingyuan

Volltext

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids von Fu, Jingyuan, Bonder, Marc Jan, Cenit, María Carmen, Tigchelaar, Ettje F, Maatman, Astrid, Dekens, Jackie A.M, Brandsma, Eelke, Marczynska, Joanna, Imhann, Floris, Weersma, Rinse K, Franke, Lude, Poon, Tiffany W, Xavier, Ramnik J, Gevers, Dirk, Hofker, Marten H, Wijmenga, Cisca, Zhernakova, Alexandra

Volltext

The effect of host genetics on the gut microbiome von Bonder, Marc Jan, Kurilshikov, Alexander, Tigchelaar, Ettje F, Mujagic, Zlatan, Imhann, Floris, Vila, Arnau Vich, Deelen, Patrick, Vatanen, Tommi, Schirmer, Melanie, Smeekens, Sanne P, Zhernakova, Daria V, Jankipersadsing, Soesma A, Jaeger, Martin, Oosting, Marije, Cenit, Maria Carmen, Masclee, Ad A M, Swertz, Morris A, Li, Yang, Kumar, Vinod, Joosten, Leo, Harmsen, Hermie, Weersma, Rinse K, Franke, Lude, Hofker, Marten H, Xavier, Ramnik J, Jonkers, Daisy, Netea, Mihai G, Wijmenga, Cisca, Fu, Jingyuan, Zhernakova, Alexandra

Volltext

High-throughput identification of human SNPs affecting regulatory element activity von van Arensbergen, Joris, Pagie, Ludo, FitzPatrick, Vincent D., de Haas, Marcel, Baltissen, Marijke P., Comoglio, Federico, van der Weide, Robin H., Teunissen, Hans, Võsa, Urmo, Franke, Lude, de Wit, Elzo, Vermeulen, Michiel, Bussemaker, Harmen J., van Steensel, Bas

Volltext

Biological interpretation of genome-wide association studies using predicted gene functions von Pers, Tune H., Karjalainen, Juha M., Chan, Yingleong, Westra, Harm-Jan, Wood, Andrew R., Yang, Jian, Lui, Julian C., Vedantam, Sailaja, Gustafsson, Stefan, Esko, Tonu, Frayling, Tim, Speliotes, Elizabeth K., Boehnke, Michael, Raychaudhuri, Soumya, Fehrmann, Rudolf S. N., Hirschhorn, Joel N., Franke, Lude

Volltext

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations von Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.

Volltext

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans von Li, Yang, Oosting, Marije, Smeekens, Sanne P., Jaeger, Martin, Aguirre-Gamboa, Raul, Le, Kieu T.T., Deelen, Patrick, Ricaño-Ponce, Isis, Schoffelen, Teske, Jansen, Anne F.M., Swertz, Morris A., Withoff, Sebo, van de Vosse, Esther, van Deuren, Marcel, van de Veerdonk, Frank, Zhernakova, Alexandra, van der Meer, Jos W.M., Xavier, Ramnik J., Franke, Lude, Joosten, Leo A.B., Wijmenga, Cisca, Kumar, Vinod, Netea, Mihai G.

Volltext

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure von Oelen, Roy, de Vries, Dylan H., Brugge, Harm, Gordon, M. Grace, Vochteloo, Martijn, Ye, Chun J., Westra, Harm-Jan, Franke, Lude, van der Wijst, Monique G. P.

Volltext

A linear mixed-model approach to study multivariate gene–environment interactions von Moore, Rachel, Casale, Francesco Paolo, Jan Bonder, Marc, Horta, Danilo, Franke, Lude, Barroso, Inês, Stegle, Oliver

Volltext

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells von Kasela, Silva, Kisand, Kai, Tserel, Liina, Kaleviste, Epp, Remm, Anu, Fischer, Krista, Esko, Tõnu, Westra, Harm-Jan, Fairfax, Benjamin P, Makino, Seiko, Knight, Julian C, Franke, Lude, Metspalu, Andres, Peterson, Pärt, Milani, Lili

Volltext

Translational insights from single-cell technologies across the cardiovascular disease continuum von van Blokland, Irene V., Groot, Hilde E., Franke, Lude H., van der Wijst, Monique G.P., van der Harst, Pim

Volltext

Demuxafy: improvement in droplet assignment by integrating multiple single-cell demultiplexing and doublet detection methods von Neavin, Drew, Senabouth, Anne, Arora, Himanshi, Lee, Jimmy Tsz Hang, Ripoll-Cladellas, Aida, Franke, Lude, Prabhakar, Shyam, Ye, Chun Jimmie, McCarthy, Davis J, Melé, Marta, Hemberg, Martin, Powell, Joseph E

Volltext

Improving the diagnostic yield of exome- sequencing by predicting gene–phenotype associations using large-scale gene expression analysis von Deelen, Patrick, van Dam, Sipko, Herkert, Johanna C., Karjalainen, Juha M., Brugge, Harm, Abbott, Kristin M., van Diemen, Cleo C., van der Zwaag, Paul A., Gerkes, Erica H., Zonneveld-Huijssoon, Evelien, Boer-Bergsma, Jelkje J., Folkertsma, Pytrik, Gillett, Tessa, van der Velde, K. Joeri, Kanninga, Roan, van den Akker, Peter C., Jan, Sabrina Z., Hoorntje, Edgar T., te Rijdt, Wouter P., Vos, Yvonne J., Jongbloed, Jan D. H., van Ravenswaaij-Arts, Conny M. A., Sinke, Richard, Sikkema-Raddatz, Birgit, Kerstjens-Frederikse, Wilhelmina S., Swertz, Morris A., Franke, Lude

Volltext

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs von Vochteloo, Martijn, Deelen, Patrick, Vink, Britt, Tsai, Ellen A, Runz, Heiko, Andreu-Sánchez, Sergio, Fu, Jingyuan, Zhernakova, Alexandra, Westra, Harm-Jan, Franke, Lude

Volltext

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression von Jonkman, Thomas H, Dekkers, Koen F, Slieker, Roderick C, Grant, Crystal D, Ikram, M Arfan, van Greevenbroek, Marleen M J, Franke, Lude, Veldink, Jan H, Boomsma, Dorret I, Slagboom, P Eline, Consortium, B I O S, Heijmans, Bastiaan T

Volltext