Engineering of a red-light–activated human cAMP/cGMP-specific phosphodiesterase von Gasser, Carlos, Taiber, Sandra, Yeh, Chen-Min, Wittig, Charlotte Helene, Hegemann, Peter, Ryu, Soojin, Wunder, Frank, Möglich, Andreas

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Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure von Follmann, Markus, Ackerstaff, Jens, Redlich, Gorden, Wunder, Frank, Lang, Dieter, Kern, Armin, Fey, Peter, Griebenow, Nils, Kroh, Walter, Becker-Pelster, Eva-Maria, Kretschmer, Axel, Geiss, Volker, Li, Volkhart, Straub, Alexander, Mittendorf, Joachim, Jautelat, Rolf, Schirok, Hartmut, Schlemmer, Karl-Heinz, Lustig, Klemens, Gerisch, Michael, Knorr, Andreas, Tinel, Hanna, Mondritzki, Thomas, Trübel, Hubert, Sandner, Peter, Stasch, Johannes-Peter

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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 von Li, Huanyu Z., Pike, Ashley C. W., Chang, Yung-Ning, Prakaash, Dheeraj, Gelova, Zuzana, Stanka, Josefina, Moreau, Christophe, Scott, Hannah C., Wunder, Frank, Wolf, Gernot, Scacioc, Andreea, McKinley, Gavin, Batoulis, Helena, Mukhopadhyay, Shubhashish, Garofoli, Andrea, Pinto-Fernández, Adán, Kessler, Benedikt M., Burgess-Brown, Nicola A., Štefanić, Saša, Wiedmer, Tabea, Dürr, Katharina L., Puetter, Vera, Ehrmann, Alexander, Khalid, Syma, Ingles-Prieto, Alvaro, Superti-Furga, Giulio, Sauer, David B.

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Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC von Becker-Pelster, Eva M, Hahn, Michael G, Delbeck, Martina, Dietz, Lisa, Hüser, Jörg, Kopf, Johannes, Kraemer, Thomas, Marquardt, Tobias, Mondritzki, Thomas, Nagelschmitz, Johannes, Nikkho, Sylvia M, Pires, Philippe V, Tinel, Hanna, Weimann, Gerrit, Wunder, Frank, Sandner, Peter, Schuhmacher, Joachim, Stasch, Johannes-Peter, Truebel, Hubert K F

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Characterization of the First Potent and Selective PDE9 Inhibitor Using a cGMP Reporter Cell Line von Wunder, Frank, Tersteegen, Adrian, Rebmann, Annegret, Erb, Christina, Fahrig, Thomas, Hendrix, Martin

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Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension von Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter

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Identification of Residues Crucially Involved in the Binding of the Heme Moiety of Soluble Guanylate Cyclase von Schmidt, Peter M., Schramm, Matthias, Schröder, Henning, Wunder, Frank, Stasch, Johannes-Peter

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Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells von Klokkers, Jens, Langehanenberg, Patrik, Kemper, Bjorn, Kosmeier, Sebastian, von Bally, Gert, Riethmuller, Christoph, Wunder, Frank, Sindic, Aleksandra, Pavenstadt, Hermann, Schlatter, Eberhard, Edemir, Bayram

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A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology von Durrant, Jacob D, Amaro, Rommie E, Xie, Lei, Urbaniak, Michael D, Ferguson, Michael A J, Haapalainen, Antti, Chen, Zhijun, Di Guilmi, Anne Marie, Wunder, Frank, Bourne, Philip E, McCammon, J Andrew

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Pharmacological and Kinetic Characterization of Adrenomedullin 1 and Calcitonin Gene-Related Peptide 1 Receptor Reporter Cell Lines von Wunder, Frank, Rebmann, Annegret, Geerts, Andreas, Kalthof, Bernd

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PDE2 at the crossway between cAMP and cGMP signalling in the heart von Weber, Silvio, Zeller, Miriam, Guan, Kaomei, Wunder, Frank, Wagner, Michael, El-Armouche, Ali

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Immunohistochemical Localization of Five Members of the KV1 Channel Subunits: Contrasting Subcellular Locations and Neuron-specific Co-localizations in Rat Brain von Veh, Rüdiger W., Lichtinghagen, Ralf, Sewing, Sabine, Wunder, Frank, Grumbach, Isabella M., Pongs, Olaf

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Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042) von Hahn, Michael G, Lampe, Thomas, El Sheikh, Sherif, Griebenow, Nils, Woltering, Elisabeth, Schlemmer, Karl-Heinz, Dietz, Lisa, Gerisch, Michael, Wunder, Frank, Becker-Pelster, Eva-Maria, Mondritzki, Thomas, Tinel, Hanna, Knorr, Andreas, Kern, Armin, Lang, Dieter, Hueser, Joerg, Schomber, Tibor, Benardeau, Agnes, Eitner, Frank, Truebel, Hubert, Mittendorf, Joachim, Kumar, Vijay, van den Akker, Focco, Schaefer, Martina, Geiss, Volker, Sandner, Peter, Stasch, Johannes-Peter

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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α 2B Antagonist von Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D, Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank

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Establishment of a novel, cell-based autotaxin assay von Dobersalske, Celia, Grundmann, Manuel, Timmermann, Andreas, Theisen, Laura, Kölling, Florian, Harris, Raymond C., Fuerstner, Chantal, Becker, Michael S., Wunder, Frank

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BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor von Meibom, Daniel, Micus, Sina, Andreevski, Anna Lena, Anlauf, Sonja, Bogner, Pamela, von Buehler, Clemens-Jeremias, Dieskau, André P., Dreher, Jan, Eitner, Frank, Fliegner, Daniela, Follmann, Markus, Gericke, Kersten Matthias, Maassen, Stefanie, Meyer, Jutta, Schlemmer, Karl-Heinz, Steuber, Holger, Tersteegen, Adrian, Wunder, Frank

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Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY‐747 designed for the treatment of resistant hypertension von Wunder, Frank, Stasch, Johannes‐Peter, Knorr, Andreas, Mondritzki, Thomas, Brockschnieder, Damian, Becker‐Pelster, Eva‐Maria, Sandner, Peter, Tinel, Hanna, Redlich, Gorden, Hartung, Ingo V., Vakalopoulos, Alexandros, Follmann, Markus

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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes von Egbert, Jeremy R, Shuhaibar, Leia C, Edmund, Aaron B, Van Helden, Dusty A, Robinson, Jerid W, Uliasz, Tracy F, Baena, Valentina, Geerts, Andreas, Wunder, Frank, Potter, Lincoln R, Jaffe, Laurinda A

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Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production von Milde, Markus, Rinne, Andreas, Wunder, Frank, Engelhardt, Stefan, Bünemann, Moritz

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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α2B Antagonist von Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D., Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank

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