Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis von Bashore, Frances M., Marquez, Ariana B., Chaikuad, Apirat, Howell, Stefanie, Dunn, Andrea S., Beltran, Alvaro A., Smith, Jeffery L., Drewry, David H., Beltran, Adriana S., Axtman, Alison D.

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM von Bashore, Frances M, Katis, Vittorio L, Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J, Rygiel, Karolina A, Leisner, Tina M, Chalk, Rod, Mishra, Swati, Williams, C Andrew, Gileadi, Opher, Brennan, Paul E, Wiley, Jesse C, Gockley, Jake, Cary, Gregory A, Carter, Gregory W, Young, Jessica E, Pearce, Kenneth H, Fu, Haian, Axtman, Alison D

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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology von Castano, Anna, Silvestre, Margaux, Wells, Carrow I, Sanderson, Jennifer L, Ferrer, Carla A, Ong, Han Wee, Lang, Yi, Richardson, William, Silvaroli, Josie A, Bashore, Frances M, Smith, Jeffery L, Genereux, Isabelle M, Dempster, Kelvin, Drewry, David H, Pabla, Navlot S, Bullock, Alex N, Benke, Tim A, Ultanir, Sila K, Axtman, Alison D

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Fused Tetrahydroquinolines Are Interfering with Your Assay von Bashore, Frances M, Annor-Gyamfi, Joel, Du, Yuhong, Katis, Vittorio, Nwogbo, Felix, Flax, Raymond G, Frye, Stephen V, Pearce, Kenneth H, Fu, Haian, Willson, Timothy M, Drewry, David H, Axtman, Alison D

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PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components von Bashore, Frances M., Foley, Caroline A., Ong, Han Wee, Rectenwald, Justin M., Hanley, Ronan P., Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Mills, Christine A., Pearce, Kenneth H., Herring, Laura E., Kireev, Dmitri, Frye, Stephen V., James, Lindsey I.

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Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease von Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.

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Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2 von Davis-Gilbert, Zachary W., Krämer, Andreas, Dunford, James E., Howell, Stefanie, Senbabaoglu, Filiz, Wells, Carrow I., Bashore, Frances M., Havener, Tammy M., Smith, Jeffery L., Hossain, Mohammad A., Oppermann, Udo, Drewry, David H., Axtman, Alison D.

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Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2 von Bashore, Frances M., Min, Sophia M., Chen, Xiangrong, Howell, Stefanie, Rinderle, Caroline H., Morel, Gabriel, Silvaroli, Josie A., Wells, Carrow I., Bunnell, Bruce A., Drewry, David H., Pabla, Navjot S., Ultanir, Sila K., Bullock, Alex N., Axtman, Alison D.

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Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants von Capener, Jacob L., Vasta, James D., Katis, Vittorio L., Michaud, Ani, Beck, Michael T., Daglish, Sabrina C. D., Cohen-Kedar, Sarit, Shaham Barda, Efrat, Howell, Stefanie, Dotan, Iris, Robers, Matthew B., Axtman, Alison D., Bashore, Frances M.

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Efforts toward discovering inhibitors of the SYK SH2–FCER1γ interaction as potential Alzheimer’s disease chemical probes and therapeutics von Sikdar, Arunima, Bashore, Frances M., Katis, Vittorio, Bradshaw, William, Rygiel, Karolina, Du, Yuhong, Wang, Dongxue, Leisner, Tina, Hardy, Brian P., Kireev, Dmitri B., Pearce, Kenneth H., Fu, Haian, Frye, Stephen V., Axtman, Alison D.

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM von Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

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