A reductive aminase from Aspergillus oryzae von Aleku, Godwin A., France, Scott P., Man, Henry, Mangas-Sanchez, Juan, Montgomery, Sarah L., Sharma, Mahima, Leipold, Friedemann, Hussain, Shahed, Grogan, Gideon, Turner, Nicholas J.

Volltext

The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development von France, Scott P., Lewis, Russell D., Martinez, Carlos A.

Volltext

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis von Aleku, Godwin A, Man, Henry, France, Scott P, Leipold, Friedemann, Hussain, Shahed, Toca-Gonzalez, Laura, Marchington, Rebecca, Hart, Sam, Turkenburg, Johan P, Grogan, Gideon, Turner, Nicholas J

Volltext

An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines von Hussain, Shahed, Leipold, Friedemann, Man, Henry, Wells, Elizabeth, France, Scott P., Mulholland, Keith R., Grogan, Gideon, Turner, Nicholas J.

Volltext

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines von France, Scott P., Aleku, Godwin A., Sharma, Mahima, Mangas‐Sanchez, Juan, Howard, Roger M., Steflik, Jeremy, Kumar, Rajesh, Adams, Ralph W., Slabu, Iustina, Crook, Robert, Grogan, Gideon, Wallace, Timothy W., Turner, Nicholas J.

Volltext

Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase von Aleku, Godwin A., Mangas‐Sanchez, Juan, Citoler, Joan, France, Scott P., Montgomery, Sarah L., Heath, Rachel S., Thompson, Matthew P., Turner, Nicholas J.

Volltext

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways von France, Scott P, Hepworth, Lorna J, Turner, Nicholas J, Flitsch, Sabine L

Volltext

Imine reductases (IREDs) von Mangas-Sanchez, Juan, France, Scott P, Montgomery, Sarah L, Aleku, Godwin A, Man, Henry, Sharma, Mahima, Ramsden, Jeremy I, Grogan, Gideon, Turner, Nicholas J

Volltext

Carboxylic acid reductases (CARs): An industrial perspective von Derrington, Sasha R., Turner, Nicholas J., France, Scott P.

Volltext

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines von Hepworth, Lorna J, France, Scott P, Hussain, Shahed, Both, Peter, Turner, Nicholas J, Flitsch, Sabine L

Volltext

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases von Sharma, Mahima, Mangas-Sanchez, Juan, France, Scott P, Aleku, Godwin A, Montgomery, Sarah L, Ramsden, Jeremy I, Turner, Nicholas J, Grogan, Gideon

Volltext

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω‑Transaminase (ω-TA), and Imine Reductase (IRED) Biocataly... von France, Scott P, Hussain, Shahed, Hill, Andrew M, Hepworth, Lorna J, Howard, Roger M, Mulholland, Keith R, Flitsch, Sabine L, Turner, Nicholas J

Volltext

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N‑Heterocycles von Thorpe, Thomas W, France, Scott P, Hussain, Shahed, Marshall, James R, Zawodny, Wojciech, Mangas-Sanchez, Juan, Montgomery, Sarah L, Howard, Roger M, Daniels, David S. B, Kumar, Rajesh, Parmeggiani, Fabio, Turner, Nicholas J

Volltext

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination von France, Scott P., Howard, Roger M., Steflik, Jeremy, Weise, Nicholas J., Mangas‐Sanchez, Juan, Montgomery, Sarah L., Crook, Robert, Kumar, Rajesh, Turner, Nicholas J.

Volltext

Synthetic Approaches to the New Drugs Approved During 2022 von France, Scott P., Lindsey, Erick A., McInturff, Emma L., Berritt, Simon, Carney, Daniel W., DeForest, Jacob C., Fink, Sarah J., Flick, Andrew C., Gibson, Tony S., Gray, Kaitlyn, Johnson, Amber M., Leverett, Carolyn A., Liu, Yiyang, Mahapatra, Subham, Watson, Rebecca B.

Volltext

A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate von Gilio, Amelia K., Thorpe, Thomas W., Heyam, Alex, Petchey, Mark R., Pogrányi, Balázs, France, Scott P., Howard, Roger M., Karmilowicz, Michael J., Lewis, Russell, Turner, Nicholas, Grogan, Gideon

Volltext

Synthetic Approaches to the New Drugs Approved During 2020 von Flick, Andrew C., Leverett, Carolyn A., Ding, Hong X., McInturff, Emma L., Fink, Sarah J., Mahapatra, Subham, Carney, Daniel W., Lindsey, Erick A., DeForest, Jacob C., France, Scott P., Berritt, Simon, Bigi-Botterill, Simone V., Gibson, Tony S., Watson, Rebecca B., Liu, Yiyang, O’Donnell, Christopher J.

Volltext

Synthetic Approaches to the New Drugs Approved during 2019 von Flick, Andrew C, Leverett, Carolyn A, Ding, Hong X, McInturff, Emma, Fink, Sarah J, Mahapatra, Subham, Carney, Daniel W, Lindsey, Erick A, DeForest, Jacob C, France, Scott P, Berritt, Simon, Bigi-Botterill, Simone V, Gibson, Tony S, Liu, Yiyang, O’Donnell, Christopher J

Volltext

Synthetic Approaches to the New Drugs Approved During 2021 von McInturff, Emma L., France, Scott P., Leverett, Carolyn A., Flick, Andrew C., Lindsey, Erick A., Berritt, Simon, Carney, Daniel W., DeForest, Jacob C., Ding, Hong X., Fink, Sarah J., Gibson, Tony S., Gray, Kaitlyn, Hubbell, Aran K., Johnson, Amber M., Liu, Yiyang, Mahapatra, Subham, McAlpine, Indrawan J., Watson, Rebecca B., O’Donnell, Christopher J.

Volltext

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease von Gopalsamy, Ariamala, Aulabaugh, Ann E., Barakat, Amey, Beaumont, Kevin C., Cabral, Shawn, Canterbury, Daniel P., Casimiro-Garcia, Agustin, Chang, Jeanne S., Chen, Ming Z., Choi, Chulho, Dow, Robert L., Fadeyi, Olugbeminiyi O., Feng, Xidong, France, Scott P., Howard, Roger M., Janz, Jay M., Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H., King-Ahmad, Amanda, Knee, Kelly M., Kohrt, Jeffrey T., Limberakis, Chris, Liras, Spiros, Martinez, Carlos A., McClure, Kim F., Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J., O'Connell, Thomas N., Parikh, Mihir D., Piotrowski, David W., Plotnikova, Olga, Robinson, Ralph P., Sahasrabudhe, Parag, Sharma, Raman, Thuma, Benjamin A., Vasa, Dipy, Wei, Liuqing, Wenzel, A. Zane, Withka, Jane M., Xiao, Jun, Yayla, Hatice G.

Volltext