Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal von Frøhlich, Rikke From, Veigaard, Christopher, Andersen, Félicie Faucon, McClendon, A. Kathleen, Gentry, Amanda C, Andersen, Anni Hangaard, Osheroff, Neil, Stevnsner, Tinna, Knudsen, Birgitta Ruth

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Identification of a Minimal Functional Linker in Human Topoisomerase I by Domain Swapping with Cre Recombinase von Frøhlich, Rikke From, Juul, Sissel, Nielsen, Maria Bjerre, Vinther, Maria, Veigaard, Christopher, Hede, Marianne Smedegaard, Andersen, Félicie Faucon

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Inhibition of Flp Recombinase by the Topoisomerase I-targeting Drugs, Camptothecin and NSC-314622 von Frøhlich, Rikke From, Gude Hansen, Stefan, Lisby, Michael, Grainge, Ian, Westergaard, Ole, Jayaram, Makkuni, Knudsen, Birgitta Ruth

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Regions within the N-terminal Domain of Human Topoisomerase I Exert Important Functions During Strand Rotation and DNA Binding von Frøhlich, Rikke From, Andersen, Félicie Faucon, Westergaard, Ole, Andersen, Anni Hangaard, Knudsen, Birgitta Ruth

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Biochemical and Kinetic Analysis of the RNase Active Sites of the Integrase/Tyrosine Family Site-specific DNA Recombinases von Sau, Apurba Kumar, Tribble, Gena DeVue, Grainge, Ian, Frøhlich, Rikke From, Knudsen, Birgitta Ruth, Jayaram, Makkuni

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Biochemical and kinetic analysis of the RNase active sites of the integrase/tyrosine family site-specific recombinases von Sau, Apurba Kumar, Tribble, Gena DeVue, Grainge, Ian, Frøhlich, Rikke From, Knudsen, Birgitta Ruth, Jayaram, Makkuni

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Temperature-Controlled Encapsulation and Release of an Active Enzyme in the Cavity of a Self-Assembled DNA Nanocage von Juul, Sissel, Iacovelli, Federico, Falconi, Mattia, Kragh, Sofie L, Christensen, Brian, Frøhlich, Rikke, Franch, Oskar, Kristoffersen, Emil L, Stougaard, Magnus, Leong, Kam W, Ho, Yi-Ping, Sørensen, Esben S, Birkedal, Victoria, Desideri, Alessandro, Knudsen, Birgitta R

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Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study von Andersen, Marie B, Tesauro, Cinzia, Gonzalez, María, Kristoffersen, Emil L, Alonso, Concepción, Rubiales, Gloria, Coletta, Andrea, Frøhlich, Rikke, Stougaard, Magnus, Ho, Yi-Ping, Palacios, Francisco, Knudsen, Birgitta R

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Assembly and structural analysis of a covalently closed nano-scale DNA cage von Andersen, Felicie F, Knudsen, Bjarne, Oliveira, Cristiano Luis Pinto, Frøhlich, Rikke F, Krüger, Dinna, Bungert, Jörg, Agbandje-McKenna, Mavis, McKenna, Robert, Juul, Sissel, Veigaard, Christopher, Koch, Jørn, Rubinstein, John L, Guldbrandtsen, Bernt, Hede, Marianne S, Karlsson, Göran, Andersen, Anni H, Pedersen, Jan Skov, Knudsen, Birgitta R

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Battery Concepts in Physical Chemistry: Making Your Own Organic–Inorganic Battery von Arnbjerg, Jacob, Khataee, Amirreza, Breitenbach, Thomas, Thøgersen, Jan, Christiansen, Sigurd, Gavlshøj Mortensen, Henriette, Bilde, Merete, Frøhlich Hougaard, Rikke, Bentien, Anders

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WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes von Patro, Birija Sankar, Frøhlich, Rikke, Bohr, Vilhelm A, Stevnsner, Tinna

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Sym015: A Highly Efficacious Antibody Mixture against MET -Amplified Tumors von Poulsen, Thomas Tuxen, Grandal, Michael Monrad, Skartved, Niels Jørgen Østergaard, Hald, Rikke, Alifrangis, Lene, Koefoed, Klaus, Lindsted, Trine, Fröhlich, Camilla, Pollmann, Sofie Ellebæk, Eriksen, Karsten Wessel, Dahlman, Anna, Jacobsen, Helle Jane, Bouquin, Thomas, Pedersen, Mikkel Wandahl, Horak, Ivan David, Lantto, Johan, Kragh, Michael

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Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement von Juul, Sissel, Nielsen, Christine J. F, Labouriau, Rodrigo, Roy, Amit, Tesauro, Cinzia, Jensen, Pia W, Harmsen, Charlotte, Kristoffersen, Emil L, Chiu, Ya-Ling, Frøhlich, Rikke, Fiorani, Paola, Cox-Singh, Janet, Tordrup, David, Koch, Jørn, Bienvenu, Anne-Lise, Desideri, Alessandro, Picot, Stephane, Petersen, Eskild, Leong, Kam W, Ho, Yi-Ping, Stougaard, Magnus, Knudsen, Birgitta R

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Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation von Keller, Josephine Geertsen, Hymøller, Kirstine Mejlstrup, Thorsager, Maria Eriksen, Hansen, Noriko Y, Erlandsen, Jens Uldum, Tesauro, Cinzia, Simonsen, Anne Katrine W, Andersen, Anne Bech, VandsøPetersen, Kamilla, Holm, Lise Lolle, Stougaard, Magnus, Andresen, Brage Storstein, Kristensen, Peter, Frøhlich, Rikke, Knudsen, Birgitta R

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Topoisomerase I as a biomarker: detection of activity at the single molecule level von Proszek, Joanna, Roy, Amit, Jakobsen, Ann-Katrine, Frøhlich, Rikke, Knudsen, Birgitta R, Stougaard, Magnus

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Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I von Roy, Amit, Tesauro, Cinzia, Frøhlich, Rikke, Hede, Marianne S, Nielsen, Maria J, Kjeldsen, Eigil, Bonven, Bjarne, Stougaard, Magnus, Gromova, Irina, Knudsen, Birgitta R

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Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations von Kristoffersen, Emil L, Jørgensen, Line A, Franch, Oskar, Etzerodt, Michael, Frøhlich, Rikke, Bjergbæk, Lotte, Stougaard, Magnus, Ho, Yi-Ping, Knudsen, Birgitta R

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Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities von Tesauro, Cinzia, Keller, Josephine Geertsen, Gromova, Irina, Gromov, Pavel, Frohlich, Rikke, Erlandsen, Jens Uldum, Andersen, Anni H, Stougaard, Magnus, Knudsen, Birgitta R

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Real-time detection of TDP1 activity using a fluorophore–quencher coupled DNA-biosensor von Jensen, Pia W., Falconi, Mattia, Kristoffersen, Emil L., Simonsen, Anita T., Cifuentes, Jèssica B., Marcussen, Lærke B., Frøhlich, Rikke, Vagner, Josephine, Harmsen, Charlotte, Juul, Sissel, Ho, Yi-Ping, Withers, Marjorie A., Lupski, James R., Koch, Jørn, Desideri, Alessandro, Knudsen, Birgitta R., Stougaard, Magnus

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Microfluidics-Enabled Enzyme Activity Measurement in Single Cells von Tesauro, Cinzia, Frøhlich, Rikke, Stougaard, Magnus, Ho, Yi-Ping, Knudsen, Birgitta R.

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