Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate von Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Tyler, John W, Wagner, Trixie, Fozard, John R, Trifilieff, Alexandre

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Sphingosine-1-Phosphate-Induced Airway Hyper-Reactivity in Rodents Is Mediated by the Sphingosine-1-Phosphate Type 3 Receptor von Trifilieff, Alexandre, Fozard, John R.

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A role for sensory nerves in the late asthmatic response von Raemdonck, Kristof, de Alba, Jorge, Birrell, Mark A, Grace, Megan, Maher, Sarah A, Irvin, Charles G, Fozard, John R, O'Byrne, Paul M, Belvisi, Maria G

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The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist von Baur, François, Beattie, David, Beer, David, Bentley, David, Bradley, Michelle, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard, Ernst, Roland, Fairhurst, Robin A, Faller, Bernard, Farr, David, Keller, Thomas, Fozard, John R, Fullerton, Joe, Garman, Sheila, Hatto, Julia, Hayden, Claire, He, Handan, Howes, Colin, Janus, Diana, Jiang, Zhengjin, Lewis, Christine, Loeuillet-Ritzler, Frederique, Moser, Heinz, Reilly, John, Steward, Alan, Sykes, David, Tedaldi, Lauren, Trifilieff, Alexandre, Tweed, Morris, Watson, Simon, Wissler, Elke, Wyss, Daniel

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MRI of lung parenchyma in rats and mice using a gradient-echo sequence von Beckmann, Nicolau, Tigani, Bruno, Mazzoni, Lazzaro, Fozard, John R.

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Noninvasive detection of endotoxin-induced mucus hypersecretion in rat lung by MRI von Beckmann, Nicolau, Tigani, Bruno, Sugar, Rosemary, Jackson, Alan D, Jones, Gareth, Mazzoni, Lazzaro, Fozard, John R

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The case for a role for adenosine in asthma: almost convincing? von Fozard, John R

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An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol von Beattie, David, Beer, David, Bradley, Michelle E, Bruce, Ian, Charlton, Steven J, Cuenoud, Bernard M, Fairhurst, Robin A, Farr, David, Fozard, John R, Janus, Diana, Rosethorne, Elizabeth M, Sandham, David A, Sykes, David A, Trifilieff, Alexandre, Turner, Katharine L, Wissler, Elke

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An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol von Beattie, David, Beer, David, Bradley, Michelle E., Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Farr, David, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth M., Sandham, David A., Sykes, David A., Trifilieff, Alexandre, Turner, Katharine L., Wissler, Elke

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Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat von FOZARD, John R, ELLIS, Karen M, DANTAS, Maria F, TIGANI, Bruno, MAZZONI, Lazzaro

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Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog von FOZARD, John R, BAUR, Francois, WOLBER, Cedric

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Stereoselective Preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a Potent and Orally Active Dual... von Gerspacher, Marc, Lewis, Christine, Ball, Howard A, Howes, Colin, Subramanian, Natarajan, Ryffel, Karin, Fozard, John R

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Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI von Tigani, Bruno, Cannet, Catherine, Karmouty-Quintana, Harry, Ble, Francois-Xavier, Zurbruegg, Stefan, Schaeublin, Elisabeth, Fozard, John R, Beckmann, Nicolau

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Bleomycin-induced lung injury assessed noninvasively and in spontaneously breathing rats by proton MRI von Karmouty-Quintana, Harry, Cannet, Catherine, Zurbruegg, Stefan, Blé, François-Xavier, Fozard, John R., Page, Clive P., Beckmann, Nicolau

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Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition von Müller, Thomas, Engels, Peter, Fozard, John R.

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Techniques: Magnetic resonance imaging of the lung provides potential for non-invasive preclinical evaluation of drugs von Beckmann, Nicolau, Tigani, Bruno, Mazzoni, Lazzaro, Fozard, John R

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Proton MRI as a noninvasive tool to assess elastase-induced lung damage in spontaneously breathing rats von Quintana, Harry Karmouty, Cannet, Catherine, Zurbruegg, Stefan, Blé, François-Xavier, Fozard, John R., Page, Clive P., Beckmann, Nicolau

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Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat von Quintana, Harry Karmouty, Cannet, Catherine, Schaeublin, Elisabeth, Zurbruegg, Stefan, Sugar, Rosemary, Mazzoni, Lazzaro, Page, Clive P, Fozard, John R, Beckmann, Nicolau

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The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats von Wolber, Cedric, Fozard, John R

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Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists von BEATTIE, David, BREARLEY, Andrew, NANSON, Lana, NEEF, James, OAKMAN, Helen, SPOONER, Gillian, TAYLOR, Roger J, TURNER, Robert J, WEST, Ryan, WOODWARD, Hannah, BROWN, Zarin, CHARLTON, Steven J, COX, Brian, FAIRHURST, Robin A, FOZARD, John R, GEDECK, Peter, KIRKHAM, Paul, MEJA, Koremu

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