Acidic triazoles as soluble guanylate cyclase stimulators von Roberts, Lee R., Bradley, Paul A., Bunnage, Mark E., England, Katherine S., Fairman, David, Fobian, Yvette M., Fox, David N.A., Gymer, Geoff E., Heasley, Steven E., Molette, Jerome, Smith, Graham L., Schmidt, Michelle A., Tones, Michael A., Dack, Kevin N.

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Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection von Tran, Thien-Duc, Pryde, David C., Jones, Peter, Adam, Fiona M., Benson, Neil, Bish, Gerwyn, Calo, Frederick, Ciaramella, Guiseppe, Dixon, Rachel, Duckworth, Jonathan, Fox, David N.A., Hay, Duncan A., Hitchin, James, Horscroft, Nigel, Howard, Martin, Gardner, Iain, Jones, Hannah M., Laxton, Carl, Parkinson, Tanya, Parsons, Gemma, Proctor, Katie, Smith, Mya C., Smith, Nicholas, Thomas, Amy

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Discovery of a highly potent series of TLR7 agonists von Jones, Peter, Pryde, David C., Tran, Thien-Duc, Adam, Fiona M., Bish, Gerwyn, Calo, Frederick, Ciaramella, Guiseppe, Dixon, Rachel, Duckworth, Jonathan, Fox, David N.A., Hay, Duncan A., Hitchin, James, Horscroft, Nigel, Howard, Martin, Laxton, Carl, Parkinson, Tanya, Parsons, Gemma, Proctor, Katie, Smith, Mya C., Smith, Nicholas, Thomas, Amy

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1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors von TOLLEFSON, Michael B, ACKER, Brad A, JACOBSEN, E. J, HUGHES, Robert O, WALKER, John K, FOX, David N. A, PALMER, Michael J, FREEMAN, Sandra K, YING YU, BOND, Brian R

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Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors von Glossop, Melanie S., Bazin, Richard J., Dack, Kevin N., Fox, David N.A., MacDonald, Graeme A., Mills, Mark, Owen, Dafydd R., Phillips, Chris, Reeves, Keith A., Ringer, Tracy J., Strang, Ross S., Watson, Christine A.L.

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors von Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung

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The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilot von Andrews, David M, Broad, Laura M, Edwards, Paul J, Fox, David N A, Gallagher, Timothy, Garland, Stephen L, Kidd, Richard, Sweeney, Joseph B

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1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors von Tollefson, Michael B, Acker, Brad A, Jacobsen, E J, Hughes, Robert O, Walker, John K, Fox, David N A, Palmer, Michael J, Freeman, Sandra K, Yu, Ying, Bond, Brian R

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Enantioselective synthesis of pumiliotoxin 251D. A strategy employing an allene-based electrophile-mediated cyclization von Fox, David N. A, Lathbury, David, Mahon, Mary F, Molloy, Kieran C, Gallagher, Timothy

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The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection von Pryde, David C., Tran, Thien-Duc, Jones, Peter, Parsons, Gemma C., Bish, Gerwyn, Adam, Fiona M., Smith, Mya C., Middleton, Donald S., Smith, Nick N., Calo, Frederick, Hay, Duncan, Paradowski, Michael, Proctor, Katie J. W., Parkinson, Tanya, Laxton, Carl, Fox, David N. A., Horscroft, Nigel J., Ciaramella, Giuseppe, Jones, Hannah M., Duckworth, Jonathan, Benson, Neil, Harrison, Anthony, Webster, Rob

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The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilotThe authors declare that this work was in part funded by the Royal Society... von Andrews, David M, Broad, Laura M, Edwards, Paul J, Fox, David N. A, Gallagher, Timothy, Garland, Stephen L, Kidd, Richard, Sweeney, Joseph B

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The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilot† †The authors declare that this work was in part funded by the Royal Socie... von Andrews, David M., Broad, Laura M., Edwards, Paul J., Fox, David N. A., Gallagher, Timothy, Garland, Stephen L., Kidd, Richard, Sweeney, Joseph B.

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Cationic mono- and bi-nuclear iron complexes as Lewis acid catalysts in Mukaiyama reactions von BACH, T, FOX, D. N. A, REETZ, M. T

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The diastereoselective and enantioselective substitution reactions of an isoindoline–borane complex von Ariffin, Azhar, Blake, Alexander J., Ebden, Mark R., Li, Wan-Sheung, Simpkins, Nigel S., Fox, David N. A.

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1-2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors von TOLLEFSON, Michael B, ACKER, Brad A, JACOBSEN, E. J, HUGHES, Robert O, WALKER, John K, FOX, David N. A, PALMER, Michael J, FREEMAN, Sandra K, YING YU, BOND, Brian R

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1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidine s as potent phosphodiesterase 5 (PDE5) inhibitors von Tollefson, Michael B, Acker, Brad A, Jacobsen, E J, Hughes, Robert O, Walker, John K, Fox, David NA, Palmer, Michael J, Freeman, Sandra K, Yu, Ying, Bond, Brian R

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Diastereoselective and Enantioselective Substitution Reactions of an Isoindoline-Borane Complex von Blake, Alexander J., Ebden, Mark R., Fox, David N. A., Li, Wan-Sheung, Simpkins, Nigel S.

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Asymmetric synthesis of functionalised pyrrolidines. The role of a stereogenic centre on nitrogen von FOX, D. N. A, LATHBURY, D, MAHON, M. F, MOLLOY, K. C, GALLAGHER, T

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5,7-diaminopyrazolo '4,3-d!pyrimidines with pde-5 inhibiting activity von BELL ANDREW S.,BROWN DAVID G.,DACK KEVIN,FOX DAVID N. A.,MARSH IAN R.,MORRELL ANDREW I.,PALMER MICHAEL J.,WINSLOW CAROL A

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Pharmaceutical combination of PDE5 inhibitors with ACE inhibitors von FOX, DAVID, N, A, BERNADETTE HUGHES

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