The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells von Fanning, Sean W, Jeselsohn, Rinath, Dharmarajan, Venkatasubramanian, Mayne, Christopher G, Karimi, Mostafa, Buchwalter, Gilles, Houtman, René, Toy, Weiyi, Fowler, Colin E, Han, Ross, Lainé, Muriel, Carlson, Kathryn E, Martin, Teresa A, Nowak, Jason, Nwachukwu, Jerome C, Hosfield, David J, Chandarlapaty, Sarat, Tajkhorshid, Emad, Nettles, Kendall W, Griffin, Patrick R, Shen, Yang, Katzenellenbogen, John A, Brown, Myles, Greene, Geoffrey L

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Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel von Mueller, Helen S., Fowler, Colin E., Dalin, Simona, Moiso, Enrico, Udomlumleart, Tee, Garg, Salil, Hemann, Michael T., Lees, Jacqueline A.

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Mapping quantitative trait loci associated with leaf rust resistance in five spring wheat populations using single nucleotide polymorphism markers von Bokore, Firdissa E, Knox, Ron E, Cuthbert, Richard D, Pozniak, Curtis J, McCallum, Brent D, N'Diaye, Amidou, DePauw, Ron M, Campbell, Heather L, Munro, Catherine, Singh, Arti, Hiebert, Colin W, McCartney, Curt A, Sharpe, Andrew G, Singh, Asheesh K, Spaner, Dean, Fowler, D B, Ruan, Yuefeng, Berraies, Samia, Meyer, Brad

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Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques von Li, Yan, Schindler, Suzanne E., Bollinger, James G., Ovod, Vitaliy, Mawuenyega, Kwasi G., Weiner, Michael W., Shaw, Leslie M., Masters, Colin L., Fowler, Christopher J., Trojanowski, John Q., Korecka, Magdalena, Martins, Ralph N., Janelidze, Shorena, Hansson, Oskar, Bateman, Randall J.

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Molecular helices as electron acceptors in high-performance bulk heterojunction solar cells von Zhong, Yu, Trinh, M. Tuan, Chen, Rongsheng, Purdum, Geoffrey E., Khlyabich, Petr P., Sezen, Melda, Oh, Seokjoon, Zhu, Haiming, Fowler, Brandon, Zhang, Boyuan, Wang, Wei, Nam, Chang-Yong, Sfeir, Matthew Y., Black, Charles T., Steigerwald, Michael L., Loo, Yueh-Lin, Ng, Fay, Zhu, X.-Y., Nuckolls, Colin

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Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology von Jiwaji, Zoeb, Tiwari, Sachin S., Avilés-Reyes, Rolando X., Hooley, Monique, Hampton, David, Torvell, Megan, Johnson, Delinda A., McQueen, Jamie, Baxter, Paul, Sabari-Sankar, Kayalvizhi, Qiu, Jing, He, Xin, Fowler, Jill, Febery, James, Gregory, Jenna, Rose, Jamie, Tulloch, Jane, Loan, Jamie, Story, David, McDade, Karina, Smith, Amy M., Greer, Peta, Ball, Matthew, Kind, Peter C., Matthews, Paul M., Smith, Colin, Dando, Owen, Spires-Jones, Tara L., Johnson, Jeffrey A., Chandran, Siddharthan, Hardingham, Giles E.

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Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial von Aley, Parvinder K, Clutterbuck, Elizabeth A, Dold, Christina, Heath, Paul, Makinson, Rebecca, Pollock, Katrina M, Ramasamy, Maheshi, Robinson, Hannah, Douglas, Alexander D, Lambe, Teresa, Aboagye, Jeremy, Allen, Elizabeth, Anslow, Rachel, Baker, Philip, Bates, Louise, Batten, Alexander, Berry, Lisa, Beveridge, Amy, Bingham, Tracey, Brunt, Emily, Burbage, Jamie, Carroll, Miles W., Coombes, Naomi S., Cooper, Rachel, Crocker, Wendy E.M., Di Maso, Claudio, Dong, Tao, Douglas, Naomi, Downing, Charlotte, Elias, Sean C., Emary, Katherine R.W., Fletcher, Clare, Ford, Karen J., Fox, Polly, Frater, John, Galiza, Eva, Godwin, Kerry, Gorini, Giacomo, Goulston, Lyndsey, Gracie, Lara, Halwe, Sandro, Hamilton, Elizabeth, Hamlyn, Joseph, Harding, Irasha, Head, Ian, Hodgson, Susanne H.C., Howell, Nicola, Isitt, Catherine, Kailath, Reshma, Karampatsas, Konstantinos, Kerridge, Simon, Khan, Uzma, Kingham-Page, Lucy, Knott, Daniel, Koleva, Stanislava, Kupke, Alexandra, Lawrie, Alison M., Lee, Arlene, Lees, Emily A, Lias, Amelia M., Linder, Aline, Lopez Ramon, Raquel, Marlow, Emma, Marshall, Julia L., Meddaugh, Gretchen, Moore, Maria, Moran, Edward, Morris, Susan Jane, Morshead, Gertraud, Muller, Jilly, Munro, Alasdair, Noé, Andrés, O'Brien, Katie, O'Connor, Daniel, Oguti, Blanché, Oliver, Jennifer L., Osborn, Mairead, Pacurar, Mihaela, Pearce, Jennifer, Pfafferott, Katja, Poulton, Ian, Riddell, Amy, Sajjad, Sara, Sanders, Helen, Sanders, Katherine, Selby, Beatrice, Shelton, Holly, Song, Rinn, Stefanova, Elena, Tait, Moira, Talbot, Helen, Themistocleous, Yrene, Thomas, Merin, Towner, James, Turkentine, Kate, Turner, Sally, Veighey, Kristin, Vichos, Iason, Worth, Andrew T., Yau, Yasmine

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Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses von Barrett, Jordan R., Belij-Rammerstorfer, Sandra, Dold, Christina, Ewer, Katie J., Folegatti, Pedro M., Gilbride, Ciaran, Halkerston, Rachel, Hill, Jennifer, Jenkin, Daniel, Stockdale, Lisa, Verheul, Marije K., Aley, Parvinder K., Angus, Brian, Bellamy, Duncan, Berrie, Eleanor, Bibi, Sagida, Bittaye, Mustapha, Carroll, Miles W., Cavell, Breeze, Clutterbuck, Elizabeth A., Edwards, Nick, Flaxman, Amy, Fuskova, Michelle, Gorringe, Andrew, Hallis, Bassam, Kerridge, Simon, Lawrie, Alison M., Linder, Aline, Liu, Xinxue, Madhavan, Meera, Makinson, Rebecca, Mellors, Jack, Minassian, Angela, Moore, Maria, Mujadidi, Yama, Plested, Emma, Poulton, Ian, Ramasamy, Maheshi N., Robinson, Hannah, Rollier, Christine S., Song, Rinn, Snape, Matthew D., Tarrant, Richard, Taylor, Stephen, Thomas, Kelly M., Voysey, Merryn, Watson, Marion E. E., Wright, Daniel, Douglas, Alexander D., Green, Catherine M., Hill, Adrian V. S., Lambe, Teresa, Gilbert, Sarah, Pollard, Andrew J.

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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 von Goligher, Ewan C, Bradbury, Charlotte A, McVerry, Bryan J, Lawler, Patrick R, Berger, Jeffrey S, Gong, Michelle N, Carrier, Marc, Reynolds, Harmony R, Kumar, Anand, Turgeon, Alexis F, Kornblith, Lucy Z, Kahn, Susan R, Marshall, John C, Kim, Keri S, Houston, Brett L, Derde, Lennie P G, Cushman, Mary, Tritschler, Tobias, Angus, Derek C, Godoy, Lucas C, McQuilten, Zoe, Kirwan, Bridget-Anne, Farkouh, Michael E, Brooks, Maria M, Lewis, Roger J, Berry, Lindsay R, Lorenzi, Elizabeth, Gordon, Anthony C, Ahuja, Tania, Al-Beidh, Farah, Annane, Djillali, Arabi, Yaseen M, Aryal, Diptesh, Baumann Kreuziger, Lisa, Beane, Abi, Bhimani, Zahra, Bihari, Shailesh, Billett, Henny H, Bond, Lindsay, Bonten, Marc, Brunkhorst, Frank, Buxton, Meredith, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Cheng, Allen C, Chkhikvadze, Tamta, Coiffard, Benjamin, Contreras, Aira, Costantini, Todd W, de Brouwer, Sophie, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Effron, Mark B, Eng, Heather F, Escobedo, Jorge, Estcourt, Lise J, Everett, Brendan M, Fergusson, Dean A, Fitzgerald, Mark, Fowler, Robert A, Froess, Joshua D, Fu, Zhuxuan, Galanaud, Jean P, Galen, Benjamin T, Gandotra, Sheetal, Girard, Timothy D, Goodman, Andrew L, Goossens, Herman, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Haniffa, Rashan, Hegde, Sheila M, Hendrickson, Carolyn M, Higgins, Alisa M, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Horvat, Christopher M, Huang, David T, Hudock, Kristin, Hunt, Beverley J, Husain, Mansoor, Hyzy, Robert C, Jacobson, Jeffrey R, Jayakumar, Devachandran, Keller, Norma M, Khan, Akram, Kim, Yuri, Kindzelski, Andrei, King, Andrew J, Knudson, M Margaret, Kornblith, Aaron E, Kutcher, Matthew E, Laffan, Michael A, Lamontagne, Francois, Le Gal, Grégoire

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SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) von Wellington, Edgar, Cole, Michelle J, Brown, Colin S, Hopkins, Susan, Aziz, H, Camero, D, Chand, MA, Charlett, A, Crawford, H, Cole, M, Foulkes, S, Harrington, P, Hewson, J, Islam, J, Kirwan, P, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Oguti, B, Organ, S, Patel, M, Platt, S, Ramsay, M, Robotham, J, Rowe, C, Shrotri, M, Simmons, R, Staves, P, Tengbe, A, Wallace, S, Wellington, E, Zambon, M, Campbell, S, Stewart, S, Mcwilliam, S, Winchester, S, Watt, A, Slawson, N, Boyd, G, Matthews, R, Whileman, A, Jones, C, Horne, S, Walker, N, Agwuh, K, Maxwell, V, O'Kelly, A, Ridley, P, Cowley, A, Swift, P, Democratis, J, Meda, M, Smith, H, Swan, A, Murira, J, Gantert, K, Chawla, A, Westell, F, Williams, M, Crosby-Nwaobi, R, McKerron, G, Templeton, K, Elumogo, N, Elliott, J, Padgett, D, Mirfenderesky, M, Cross, A, Howard, M, Brand, S, Sheridan, L, Wadams, B, Mouland, J, Giles, J, Boldock, E, Gormley, S, Tazzyman, S, Jones, A, Price, C, Pepperell, J, Schultz, M, McCracken, D, Kalakonda, N, Khanduri, S, Harwood, J, Payne, B, Staines, N, Hughes, LE, Roebuck, A, Reynolds, T, Wiselka, M, Virgilio, E, Chin, T, Jones, N, Mills, G, Todd, N, Jeffery, K, Dunachie, S, De Silva, T, Heeney, JL

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Morphometric Changes to Corneal Dendritic Cells in Individuals With Mild Cognitive Impairment von Dehghani, Cirous, Frost, Shaun, Jayasena, Rajiv, Fowler, Christopher, Masters, Colin L, Kanagasingam, Yogesan, Jiao, Haihan, Lim, Jeremiah K H, Chinnery, Holly R, Downie, Laura E

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Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults von Lim, Yen Ying, Baker, Jenalle E., Bruns, Loren, Mills, Andrea, Fowler, Christopher, Fripp, Jurgen, Rainey-Smith, Stephanie R., Ames, David, Masters, Colin L., Maruff, Paul

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ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes von Soldan, Anja, Pettigrew, Corinne, Fagan, Anne M, Schindler, Suzanne E, Moghekar, Abhay, Fowler, Christopher, Li, Qiao-Xin, Collins, Steven J, Carlsson, Cynthia, Asthana, Sanjay, Masters, Colin L, Johnson, Sterling, Morris, John C, Albert, Marilyn, Gross, Alden L

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Extinction risk and conservation of the world's sharks and rays von Dulvy, Nicholas K, Fowler, Sarah L, Musick, John A, Cavanagh, Rachel D, Kyne, Peter M, Harrison, Lucy R, Carlson, John K, Davidson, Lindsay Nk, Fordham, Sonja V, Francis, Malcolm P, Pollock, Caroline M, Simpfendorfer, Colin A, Burgess, George H, Carpenter, Kent E, Compagno, Leonard Jv, Ebert, David A, Gibson, Claudine, Heupel, Michelle R, Livingstone, Suzanne R, Sanciangco, Jonnell C, Stevens, John D, Valenti, Sarah, White, William T

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Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment von Bolsewig, Katharina, Willemse, Eline A. J., Sánchez-Juan, Pascual, Rábano, Alberto, Martínez, Minerva, Doecke, James D., Bellomo, Giovanni, Vermunt, Lisa, Alcolea, Daniel, Halbgebauer, Steffen, in ‘t Veld, Sjors, Mattsson-Carlgren, Niklas, Veverova, Katerina, Fowler, Christopher J., Boonkamp, Lynn, Koel-Simmelink, Marleen, Hussainali, Zulaiga, Ruiters, Daimy N., Gaetani, Lorenzo, Toja, Andrea, Fortea, Juan, Pijnenburg, Yolande, Lemstra, Afina W., van der Flier, Wiesje M., Hort, Jakub, Otto, Markus, Hansson, Oskar, Parnetti, Lucilla, Masters, Colin L., Lleó, Alberto, Teunissen, Charlotte E., Del Campo Milán, Marta

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The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis von Freeman, Daniel, Sheaves, Bryony, Goodwin, Guy M, Yu, Ly-Mee, Nickless, Alecia, Harrison, Paul J, Emsley, Richard, Luik, Annemarie I, Foster, Russell G, Wadekar, Vanashree, Hinds, Christopher, Gumley, Andrew, Jones, Ray, Lightman, Stafford, Jones, Steve, Bentall, Richard, Kinderman, Peter, Rowse, Georgina, Brugha, Traolach, Blagrove, Mark, Gregory, Alice M, Fleming, Leanne, Walklet, Elaine, Glazebrook, Cris, Davies, E Bethan, Hollis, Chris, Haddock, Gillian, John, Bev, Coulson, Mark, Fowler, David, Pugh, Katherine, Cape, John, Moseley, Peter, Brown, Gary, Hughes, Claire, Obonsawin, Marc, Coker, Sian, Watkins, Edward, Schwannauer, Matthias, MacMahon, Kenneth, Siriwardena, A Niroshan, Espie, Colin A

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Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes von McDowell, P Jane, Busby, John, Hanratty, Catherine E, Djukanovic, Ratko, Woodcock, Ashley, Walker, Samantha, Hardman, Timothy Colin, Arron, Joseph R, Choy, David F, Bradding, Peter, Brightling, Chris E, Chaudhuri, Rekha, Cowan, Douglas, Mansur, Adel H, Fowler, Stephen J, Diver, Sarah E, Howarth, Peter, Lordan, James, Menzies-Gow, Andrew, Harrison, Timothy, Robinson, Douglas S, Holweg, Cecile T J, Matthews, John G, Pavord, Ian D, Heaney, Liam G

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The genetic architecture of type 2 diabetes von Gaulton, Kyle J., McCarthy, Davis J., Sim, Xueling, Rayner, N. William, Cingolani, Pablo, Hartl, Christopher, Pearson, Richard D., Grarup, Niels, Chen, Yuhui, Chen, Peng, Go, Min Jin, Parker, Stephen C. J., Varga, Tibor V., Hu, Cheng, Kim, Bong-Jo, Kim, Yongkang, Kim, Young Jin, Maxwell, Taylor J., Nagai, Yoshihiko, Zhang, Weihua, Barzilai, Nir, Han, Bok-Ghee, Stančáková, Alena, Abboud, Hanna E., Boeing, Heiner, Prabhakaran, Dorairaj, Butterworth, Adam S., Lee, Heung Man, Kwak, Soo-Heon, Zhao, Wei, So, Wing Yee, Cheng, Ching-Yu, Curran, Joanne E., Freedman, Barry I., Kumar, Satish, van der Schouw, Yvonne T., Loh, Marie, Musani, Solomon K., Tan, Sian-Tsung, Taylor Jr, Herman A., Levy, Jonathan C., Mangino, Massimo, Bonnycastle, Lori L., Fadista, João, Surdulescu, Gabriela L., Herder, Christian, Groves, Christopher J., Brandslund, Ivan, Lyssenko, Valeriya, Hollensted, Mette, Jørgensen, Marit E., Ladenvall, Claes, Justesen, Johanne Marie, Linneberg, Allan, Qi, Qibin, Roden, Michael, Wood, Andrew R., Mihailov, Evelin, Maguire, Jared, Poplin, Ryan, Shakir, Khalid, Hrabé de Angelis, Martin, Jun, Goo, Murphy, Jacquelyn, Onofrio, Robert, Thorand, Barbara, Meisinger, Christa, Hu, Frank B., Peters, Annette, Rauramaa, Rainer, Salomaa, Veikko, Watanabe, Richard M., Bergman, Richard N., Bharadwaj, Dwaipayan, Chia, Kee Seng, Langenberg, Claudia, Elliott, Paul, Jablonski, Kathleen A., Ma, Ronald C. W., Tandon, Nikhil, Barroso, Inês, Zeggini, Eleftheria, Ried, Janina S., DeFronzo, Ralph A., Grallert, Harald, Banks, Eric, Trakalo, Joseph, Lind, Lars, Farjoun, Yossi, Owen, Katharine R., Gloyn, Anna L., Kooner, Jaspal Singh, Bowden, Donald W., Collins, Francis S., Atzmon, Gil, Hanis, Craig L., Seielstad, Mark, Frayling, Timothy M., Scott, Laura J., Altshuler, David

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Genetic architecture and evolution of color variation in American black bears von Puckett, Emily E., Davis, Isis S., Harper, Dawn C., Wakamatsu, Kazumasa, Battu, Gopal, Belant, Jerrold L., Beyer, Dean E., Carpenter, Colin, Crupi, Anthony P., Davidson, Maria, DePerno, Christopher S., Forman, Nicholas, Fowler, Nicholas L., Garshelis, David L., Gould, Nicholas, Gunther, Kerry, Haroldson, Mark, Ito, Shosuke, Kocka, David, Lackey, Carl, Leahy, Ryan, Lee-Roney, Caitlin, Lewis, Tania, Lutto, Ashley, McGowan, Kelly, Olfenbuttel, Colleen, Orlando, Mike, Platt, Alexander, Pollard, Matthew D., Ramaker, Megan, Reich, Heather, Sajecki, Jaime L., Sell, Stephanie K., Strules, Jennifer, Thompson, Seth, van Manen, Frank, Whitman, Craig, Williamson, Ryan, Winslow, Frederic, Kaelin, Christopher B., Marks, Michael S., Barsh, Gregory S.

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Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients von Hampel, Heather, Pearlman, Rachel, de la Chapelle, Albert, Pritchard, Colin C., Zhao, Weiqiang, Jones, Dan, Yilmaz, Ahmet, Chen, Wei, Frankel, Wendy L., Suarez, Adrian A., Cosgrove, Casey, Backes, Floor, Copeland, Larry, Fowler, Jeffrey, O'Malley, David, Salani, Ritu, McElroy, Joseph P., Stanich, Peter P., Goodfellow, Paul, Cohn, David E.

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