Hyaluronan synthesis and degradation in cartilage and bone von Bastow, E. R, Byers, S, Golub, S. B, Clarkin, C. E, Pitsillides, A. A, Fosang, A. J

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ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors von Fosang, A.J

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ADAMTS-5: the story so far von Fosang, A J, Rogerson, F M, East, C J, Stanton, H

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Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan von Knox, S., Fosang, A.J., Last, K., Melrose, J., Whitelock, J.

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Identifying the human aggrecanase von Fosang, A.J, Rogerson, F.M

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Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs von Gauci, S.J., Golub, S.B., Tatarczuch, L., Lee, E., Chan, D., Walsh, N.C., Little, C.B., Stanton, H., Lokmic, Z., Sims, N.A., Mackie, E.J., Fosang, A.J.

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The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B von FOSANG, A. J, NEAME, P. J, LAST, K, HARDINGHAM, T. E, MURPHY, G, HAMILTON, J. A

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Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development von Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., Thompson, E. W.

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Generation and Novel Distribution of Matrix Metalloproteinase-derived Aggrecan Fragments in Porcine Cartilage Explants von Fosang, Amanda J., Last, Karena, Stanton, Heather, Weeks, David B., Campbell, Ian K., Hardingham, Timothy E., Hembry, Rosalind M.

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Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in si... von Hughes, C E, Caterson, B, Fosang, A J, Roughley, P J, Mort, J S

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Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain von FOSANG, A. J, LAST, K, KNÄUPER, V, NEAME, P. J, MURPHY, G, HARDINGHAM, T. E, TSCHESCHE, H, HAMILTON, J. A

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Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins von FOSANG, A. J, NEAME, P. J, HARDINGHAM, T. E, MURPHY, G, HAMILTON, J. A

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Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with... von Mercuri, F A, Maciewicz, R A, Tart, J, Last, K, Fosang, A J

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MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays von Sumer, E.U., M.Sc, Sondergaard, B.C., M.Sc, Rousseau, J.C., Ph.D, Delmas, P.D., M.D., Ph.D, Fosang, A.J., Ph.D, Karsdal, M.A., Ph.D, Christiansen, C., D.M.Sc, Qvist, P., Ph.D

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Neoepitopes as biomarkers of cartilage catabolism von Fosang, A J, Stanton, H, Little, C B, Atley, L M

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Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan von Fosang, A.J., Last, K., Poon, C.J., Plaas, A.H.

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Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids von Fosang, A J, Last, K, Gardiner, P, Jackson, D C, Brown, L

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ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures von Stewart, M.C., Fosang, A.J., Bai, Y., Osborn, B., Plaas, A., Sandy, J.D.

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Degradation of cartilage aggrecan by collagenase-3 (MMP-13) von Fosang, Amanda J., Last, Karena, Knäuper, Vera, Murphy, Gillian, Neame, Peter J.

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent von Fosang, A J, Last, K, Maciewicz, R A

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