Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist von Ahuja, Shivani, Mukund, Susmith, Deng, Lunbin, Khakh, Kuldip, Chang, Elaine, Ho, Hoangdung, Shriver, Stephanie, Young, Clint, Lin, Sophia, Johnson, J. P., Wu, Ping, Li, Jun, Coons, Mary, Tam, Christine, Brillantes, Bobby, Sampang, Honorio, Mortara, Kyle, Bowman, Krista K., Clark, Kevin R., Estevez, Alberto, Xie, Zhiwei, Verschoof, Henry, Grimwood, Michael, Dehnhardt, Christoph, Andrez, Jean–Christophe, Focken, Thilo, Sutherlin, Daniel P., Safina, Brian S., Starovasnik, Melissa A., Ortwine, Daniel F., Franke, Yvonne, Cohen, Charles J., Hackos, David H., Koth, Christopher M., Payandeh, Jian

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NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats von Johnson, JP, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R

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Lewis-acid catalyzed formation of dihydropyrans von Hanessian, Stephen, Focken, Thilo, Oza, Rupal

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Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules von Focken, Thilo, Hanessian, Stephen

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Planar Chiral Imidazolium Salts in the Asymmetric Rhodium-Catalyzed 1,2-Addition of Arylboronic Acids to Aldehydes von Focken, Thilo, Rudolph, Jens, Bolm, Carsten

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Stereoselective Synthesis of Pyridinones:  Application to the Synthesis of (−)-Barrenazines von Focken, Thilo, Charette, André B

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Total Synthesis of Jerangolid A von Hanessian, Stephen, Focken, Thilo, Oza, Rupal

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The contribution of Na V 1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na V 1.6 gain-of-function (GOF) mouse seizure control von Johnson, Jr, James P, Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, de Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L, Cutts, Alison J, Sherrington, Robin P, Winquist, Raymond, Cohen, Charles J, Empfield, James R

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Targeting of NAV1.6 and NAV1.2 to Inhibit Excitatory vs Inhibitory Neural Circuits von Goodchild, Samuel J., Ghovanloo, Mohammad-Reza, Williams, Aaron, Shuart, Noah, Soriano, Maegan, Mezeyova, Janette, Dean, Richard, Focken, Thilo, Ruben, Peter, Empfield, James, Cohen, Charles, Johnson, J.p.

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The contribution of NaV1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and NaV1.6 gain‐of‐function (GOF) mouse seizure control von Johnson, James P., Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J., Andrez, Jean‐Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L., Cutts, Alison J., Sherrington, Robin P., Winquist, Raymond, Cohen, Charles J., Empfield, James R.

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Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7 von Sun, Shaoyi, Chowdhury, Sultan, Hemeon, Ivan, Hasan, Abid, Wilson, Michael S., Bergeron, Phillipe, Jia, Qi, Zenova, Alla Y., Grimwood, Mike E., Gong, Wei, Decker, Shannon M., Bichler, Paul, Andrez, Jean-Christophe, Focken, Thilo, Ngyuen, Theresa, Zhu, Jiuxiang, White, Andrew D., Bankar, Girish, Howard, Sarah, Chang, Elaine, Khakh, Kuldip, Lin, Sophia, Dean, Richard, Johnson, J.P., Chang, Jae H., Hackos, David H., McKerrall, Steve J., Sellers, Ben, Ortwine, Dan F., Cohen, Charles J., Safina, Brian S., Sutherlin, Daniel P., Dehnhardt, Christoph M.

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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy von Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, J. P, Dehnhardt, Christoph M, Empfield, James R

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Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo von Goodchild, Samuel J., Shuart, Noah Gregory, Williams, Aaron D., Ye, Wenlei, Parrish, R. Ryley, Soriano, Maegan, Thouta, Samrat, Mezeyova, Janette, Waldbrook, Matthew, Dean, Richard, Focken, Thilo, Ghovanloo, Mohammad-Reza, Ruben, Peter C., Scott, Fiona, Cohen, Charles J., Empfield, James, Johnson, JP

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Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity von Sun, Shaoyi, Jia, Qi, Zenova, Alla Y, Wilson, Michael S, Chowdhury, Sultan, Focken, Thilo, Li, Jun, Decker, Shannon, Grimwood, Michael E, Andrez, Jean-Christophe, Hemeon, Ivan, Sheng, Tao, Chen, Chien-An, White, Andy, Hackos, David H, Deng, Lunbin, Bankar, Girish, Khakh, Kuldip, Chang, Elaine, Kwan, Rainbow, Lin, Sophia, Nelkenbrecher, Karen, Sellers, Benjamin D, DiPasquale, Antonio G, Chang, Jae, Pang, Jodie, Sojo, Luis, Lindgren, Andrea, Waldbrook, Matthew, Xie, Zhiwei, Young, Clint, Johnson, James P, Robinette, C. Lee, Cohen, Charles J, Safina, Brian S, Sutherlin, Daniel P, Ortwine, Daniel F, Dehnhardt, Christoph M

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Molecular Pharmacology of Selective Na V 1.6 and Dual Na V 1.6/Na V 1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo von Goodchild, Samuel J, Shuart, Noah Gregory, Williams, Aaron D, Ye, Wenlei, Parrish, R Ryley, Soriano, Maegan, Thouta, Samrat, Mezeyova, Janette, Waldbrook, Matthew, Dean, Richard, Focken, Thilo, Ghovanloo, Mohammad-Reza, Ruben, Peter C, Scott, Fiona, Cohen, Charles J, Empfield, James, Johnson, J P

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Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa V 1.7 I... von Focken, Thilo, Chowdhury, Sultan, Zenova, Alla, Grimwood, Michael E, Chabot, Christine, Sheng, Tao, Hemeon, Ivan, Decker, Shannon M, Wilson, Michael, Bichler, Paul, Jia, Qi, Sun, Shaoyi, Young, Clint, Lin, Sophia, Goodchild, Samuel J, Shuart, Noah G, Chang, Elaine, Xie, Zhiwei, Li, Bowen, Khakh, Kuldip, Bankar, Girish, Waldbrook, Matthew, Kwan, Rainbow, Nelkenbrecher, Karen, Karimi Tari, Parisa, Chahal, Navjot, Sojo, Luis, Robinette, C Lee, White, Andrew D, Chen, Chien-An, Zhang, Yi, Pang, Jodie, Chang, Jae H, Hackos, David H, Johnson, Jr, J P, Cohen, Charles J, Ortwine, Daniel F, Sutherlin, Daniel P, Dehnhardt, Christoph M, Safina, Brian S

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Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310 von Safina, Brian S, McKerrall, Steven J, Sun, Shaoyi, Chen, Chien-An, Chowdhury, Sultan, Jia, Qi, Li, Jun, Zenova, Alla Y, Andrez, Jean-Christophe, Bankar, Girish, Bergeron, Philippe, Chang, Jae H, Chang, Elaine, Chen, Jun, Dean, Richard, Decker, Shannon M, DiPasquale, Antonio, Focken, Thilo, Hemeon, Ivan, Khakh, Kuldip, Kim, Amy, Kwan, Rainbow, Lindgren, Andrea, Lin, Sophia, Maher, Jonathan, Mezeyova, Janette, Misner, Dinah, Nelkenbrecher, Karen, Pang, Jodie, Reese, Rebecca, Shields, Shannon D, Sojo, Luis, Sheng, Tao, Verschoof, Henry, Waldbrook, Matthew, Wilson, Michael S, Xie, Zhiwei, Young, Clint, Zabka, Tanja S, Hackos, David H, Ortwine, Daniel F, White, Andrew D, Johnson, J.P, Robinette, C. Lee, Dehnhardt, Christoph M, Cohen, Charles J, Sutherlin, Daniel P

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Total Synthesis of (+)-Ambruticin S: Probing the Pharmacophoric Subunit von Hanessian, Stephen, Focken, Thilo, Mi, Xueling, Oza, Rupal, Chen, Bin, Ritson, Dougal, Beaudegnies, Renaud

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Synthesis of iridium complexes with new planar chiral chelating phosphinyl-imidazolylidene ligands and their application in asymmetric hydrogenation von Focken, Thilo, Raabe, Gerhard, Bolm, Carsten

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Discovery of Acyl-sulfonamide Na v 1.7 Inhibitors GDC-0276 and GDC-0310 von Safina, Brian S, McKerrall, Steven J, Sun, Shaoyi, Chen, Chien-An, Chowdhury, Sultan, Jia, Qi, Li, Jun, Zenova, Alla Y, Andrez, Jean-Christophe, Bankar, Girish, Bergeron, Philippe, Chang, Jae H, Chang, Elaine, Chen, Jun, Dean, Richard, Decker, Shannon M, DiPasquale, Antonio, Focken, Thilo, Hemeon, Ivan, Khakh, Kuldip, Kim, Amy, Kwan, Rainbow, Lindgren, Andrea, Lin, Sophia, Maher, Jonathan, Mezeyova, Janette, Misner, Dinah, Nelkenbrecher, Karen, Pang, Jodie, Reese, Rebecca, Shields, Shannon D, Sojo, Luis, Sheng, Tao, Verschoof, Henry, Waldbrook, Matthew, Wilson, Michael S, Xie, Zhiwei, Young, Clint, Zabka, Tanja S, Hackos, David H, Ortwine, Daniel F, White, Andrew D, Johnson, Jr, J P, Robinette, C Lee, Dehnhardt, Christoph M, Cohen, Charles J, Sutherlin, Daniel P

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