Use of In Vitro Assays to Assess Immunogenicity Risk of Antibody-Based Biotherapeutics von Joubert, Marisa K, Deshpande, Meghana, Yang, Jane, Reynolds, Helen, Bryson, Christine, Fogg, Mark, Baker, Matthew P, Herskovitz, Jonathan, Goletz, Theresa J, Zhou, Lei, Moxness, Michael, Flynn, Gregory C, Narhi, Linda O, Jawa, Vibha

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High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans von Goetze, Andrew M, Liu, Y Diana, Zhang, Zhongqi, Shah, Bhavana, Lee, Edward, Bondarenko, Pavel V, Flynn, Gregory C

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Identification and quantification of host cell protein impurities in biotherapeutics using mass spectrometry von Schenauer, Matthew R., Flynn, Gregory C., Goetze, Andrew M.

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Analysis of N-glycans from recombinant immunoglobulin G by on-line reversed-phase high-performance liquid chromatography/mass spectrometry von Chen, Xiaoyu, Flynn, Gregory C.

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Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry von Zhang, Qingchun, Goetze, Andrew M, Cui, Huanchun, Wylie, Jenna, Trimble, Steve, Hewig, Art, Flynn, Gregory C

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Effect of high mannose glycan pairing on IgG antibody clearance von Liu, Yaoqing Diana, Flynn, Gregory C.

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Evaluating Immunogenicity Risk Due to Host Cell Protein Impurities in Antibody-Based Biotherapeutics von Jawa, Vibha, Joubert, Marisa K., Zhang, Qingchun, Deshpande, Meghana, Hapuarachchi, Suminda, Hall, Michael P., Flynn, Gregory C.

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N-terminal Glutamate to Pyroglutamate Conversion in Vivo for Human IgG2 Antibodies von Liu, Y. Diana, Goetze, Andrew M., Bass, Randal B., Flynn, Gregory C.

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Cysteine Racemization on IgG Heavy and Light Chains von Zhang, Qingchun, Flynn, Gregory C.

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Characterization of the co-elution of host cell proteins with monoclonal antibodies during protein A purification von Zhang, Qingchun, Goetze, Andrew M., Cui, Huanchun, Wylie, Jenna, Tillotson, Ben, Hewig, Art, Hall, Michael P., Flynn, Gregory C.

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Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass von Dillon, Thomas M., Ricci, Margaret Speed, Vezina, Chris, Flynn, Gregory C., Liu, Yaoqing Diana, Rehder, Douglas S., Plant, Matthew, Henkle, Brad, Li, Yu, Deechongkit, Songpon, Varnum, Brian, Wypych, Jette, Balland, Alain, Bondarenko, Pavel V.

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C-terminal lysine processing of human immunoglobulin G2 heavy chain in vivo von Cai, Bing, Pan, Hai, Flynn, Gregory C

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Naturally occurring glycan forms of human immunoglobulins G1 and G2 von Flynn, Gregory C., Chen, Xiaoyu, Liu, Y. Diana, Shah, Bhavana, Zhang, Zhongqi

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Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms von Wypych, Jette, Li, Ming, Guo, Amy, Zhang, Zhongqi, Martinez, Theresa, Allen, Martin J., Fodor, Szilan, Kelner, Drew N., Flynn, Gregory C., Liu, Yaoqing Diana, Bondarenko, Pavel V., Ricci, Margaret Speed, Dillon, Thomas M., Balland, Alain

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IgG1 Thioether Bond Formation in Vivo von Zhang, Qingchun, Schenauer, Matthew R., McCarter, John D., Flynn, Gregory C.

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Glycan engineering reveals interrelated effects of terminal galactose and core fucose on antibody‐dependent cell‐mediated cytotoxicity von Zhang, Qingchun, Joubert, Marisa K., Polozova, Alla, De Guzman, Ronandro, Lakamsani, Kamala, Kinderman, Francis, Xiang, Dong, Shami, Andrew, Miscalichi, Nahira, Flynn, Gregory C., Kuhns, Scott

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Investigation of antibody disulfide reduction and re-oxidation and impact to biological activities von Wang, Tian, Liu, Yaoqing Diana, Cai, Bing, Huang, Gang, Flynn, Gregory C.

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A high-throughput microchip-based glycan screening assay for antibody cell culture samples von Primack, Jeremy, Flynn, Gregory C., Pan, Hai

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Assessing monoclonal antibody product quality attribute criticality through clinical studies von Goetze, Andrew M., Schenauer, Matthew R., Flynn, Gregory C.

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Assessment of naturally occurring covalent and total dimer levels in human IgG1 and IgG2 von Yang, Jane, Goetze, Andrew M., Flynn, Gregory C.

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