Antibody-Drug Conjugates for the Treatment of Cancer von Flygare, John A., Pillow, Thomas H., Aristoff, Paul

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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates von Staben, Leanna R., Koenig, Stefan G., Lehar, Sophie M., Vandlen, Richard, Zhang, Donglu, Chuh, Josefa, Yu, Shang-Fan, Ng, Carl, Guo, Jun, Liu, Yanzhou, Fourie-O'Donohue, Aimee, Go, MaryAnn, Linghu, Xin, Segraves, Nathaniel L., Wang, Tao, Chen, Jinhua, Wei, BinQing, Phillips, Gail D. Lewis, Xu, Keyang, Kozak, Katherine R., Mariathasan, Sanjeev, Flygare, John A., Pillow, Thomas H.

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Activity‐based probes for the multicatalytic proteasome von Hewings, David S., Flygare, John A., Wertz, Ingrid E., Bogyo, Matthew

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) von Flygare, John A, Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T, Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail, Elliott, Linda O, Feng, Bainian, Franklin, Matthew C, Reisner, Stacy Frankovitz, Gazzard, Lewis, Halladay, Jason, Hymowitz, Sarah G, La, Hank, LoRusso, Patricia, Maurer, Brigitte, Murray, Lesley, Plise, Emile, Quan, Clifford, Stephan, Jean-Philippe, Young, Shin G, Tom, Jeffrey, Tsui, Vickie, Um, Joanne, Varfolomeev, Eugene, Vucic, Domagoj, Wagner, Andrew J, Wallweber, Heidi J. A, Wang, Lan, Ware, Joseph, Wen, Zhaoyang, Wong, Harvey, Wong, Jonathan M, Wong, Melisa, Wong, Susan, Yu, Ron, Zobel, Kerry, Fairbrother, Wayne J

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Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity von Wei, BinQing, Gunzner-Toste, Janet, Yao, Hui, Wang, Tao, Wang, Jing, Xu, Zijin, Chen, Jinhua, Wai, John, Nonomiya, Jim, Tsai, Siao Ping, Chuh, Josefa, Kozak, Katherine R, Liu, Yichin, Yu, Shang-Fan, Lau, Jeff, Li, Guangmin, Phillips, Gail D, Leipold, Doug, Kamath, Amrita, Su, Dian, Xu, Keyang, Eigenbrot, Charles, Steinbacher, Stefan, Ohri, Rachana, Raab, Helga, Staben, Leanna R, Zhao, Guiling, Flygare, John A, Pillow, Thomas H, Verma, Vishal, Masterson, Luke A, Howard, Philip W, Safina, Brian

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Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights von Hewings, David S., Flygare, John A., Bogyo, Matthew, Wertz, Ingrid E.

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Novel antibody–antibiotic conjugate eliminates intracellular S. aureus von Lehar, Sophie M., Pillow, Thomas, Xu, Min, Staben, Leanna, Kajihara, Kimberly K., Vandlen, Richard, DePalatis, Laura, Raab, Helga, Hazenbos, Wouter L., Hiroshi Morisaki, J., Kim, Janice, Park, Summer, Darwish, Martine, Lee, Byoung-Chul, Hernandez, Hilda, Loyet, Kelly M., Lupardus, Patrick, Fong, Rina, Yan, Donghong, Chalouni, Cecile, Luis, Elizabeth, Khalfin, Yana, Plise, Emile, Cheong, Jonathan, Lyssikatos, Joseph P., Strandh, Magnus, Koefoed, Klaus, Andersen, Peter S., Flygare, John A., Wah Tan, Man, Brown, Eric J., Mariathasan, Sanjeev

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Between nature and society: the interpretation of an early nineteenth-century Swedish farmer's diary von Lennartsson, Tommy, Westin, Anna, Erikson, Marja, Flygare, Iréne A., Isacson, Maths, Morell, Mats

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Internet-based CBT for patients with depressive disorders in primary and psychiatric care: Is it effective and does comorbidity affect outcome? von Flygare, Anna-Lena, Engström, Ingemar, Hasselgren, Mikael, Jansson-Fröjmark, Markus, Frejgrim, Rikard, Andersson, Gerhard, Holländare, Fredrik

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Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists von Ndubaku, Chudi, Varfolomeev, Eugene, Wang, Lan, Zobel, Kerry, Lau, Kevin, Elliott, Linda O, Maurer, Brigitte, Fedorova, Anna V, Dynek, Jasmin N, Koehler, Michael, Hymowitz, Sarah G, Tsui, Vickie, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Vucic, Domagoj

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Structure-guided design of a selective BCL-XL inhibitor von Lessene, Guillaume, Czabotar, Peter E, Sleebs, Brad E, Zobel, Kerry, Lowes, Kym N, Adams, Jerry M, Baell, Jonathan B, Colman, Peter M, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Gibbons, Paul, Kersten, Wilhelmus J A, Kulasegaram, Sanji, Moss, Rebecca M, Parisot, John P, Smith, Brian J, Street, Ian P, Yang, Hong, Huang, David C S, Watson, Keith G

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Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions von Cao, Wendy, Maza, Johnathan C., Chernyak, Natalia, Flygare, John A., Krska, Shane W., Toste, F. Dean, Francis, Matthew B.

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Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates von Pillow, Thomas H, Sadowsky, Jack D, Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R, Ha, Edward, Junutula, Jagath R, Flygare, John A

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Discovery and Evaluation of TLR-Targeted Immune Agonists von Chernyak, Natalia, Bhagwat, Bhagyashree, Naravula, Saraswathi, Chen, Ying, Solban, Nicolas, Zhang, Fan, Kofman, Esther, Raoufi, Fahimeh, Dang, Xibei, Bao, Jianming, Tomazela, Daniela, Baily, Marc, Geierstanger, Bernhard, Flygare, John A., Han, Jin-Hwan, Willingham, Aarron, Seganish, W. Michael

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Progress towards Mechanism-Based Treatment for Diamond-Blackfan Anemia von Sjögren, Sara E., Flygare, Johan

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In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin von Gonciarz, Ryan L., Jiang, Honglin, Tram, Linh, Hugelshofer, Cedric L., Ekpenyong, Oscar, Knemeyer, Ian, Aron, Allegra T., Chang, Christopher J., Flygare, John A., Collisson, Eric A., Renslo, Adam R.

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Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody-Drug Conjugate Payloads von Patel, Akash M, Willingham, Aarron, Cheng, Alan C, Tomazela, Daniela, Bowman, Eddie, Kofman, Esther, Zhang, Fan, Bao, Jianming, Sanzone, Jillian R, Choy, Jonathan W, Flygare, John A, Han, Jin-Hwan, Pradhan, Komal, Kieffer, Madeleine, Chernyak, Natalia, Akbari, Peyman, Liu, Ping, Mehmood, Rimsha, Naravula, Saraswathi, Hollingsworth, Scott A, Bhagwat, Bhagyashree, Lang, Simon B, Seganish, W Michael

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Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial von Cats, Annemieke, Jansen, Edwin P M, van Grieken, Nicole C T, Sikorska, Karolina, Lind, Pehr, Nordsmark, Marianne, Meershoek-Klein Kranenbarg, Elma, Boot, Henk, Trip, Anouk K, Swellengrebel, H A Maurits, van Laarhoven, Hanneke W M, Putter, Hein, van Sandick, Johanna W, van Berge Henegouwen, Mark I, Hartgrink, Henk H, van Tinteren, Harm, van de Velde, Cornelis J H, Verheij, Marcel, Van Coevorden, Frits, Vanhoutvin, Steven, Hulshof, Maarten CCM, Loosveld, Olaf JL, Ten Tije, A (Bert) Jan, Erdkamp, Frans LG, Warmerdam, Fabienne ARM, Van der Peet, Donald L, Verheul, Henk MW, Boerma, Djamila, Los, Maartje, Slot, Annerie, Houtsma, Danny, Portielje, Johanna EA, Blaisse, Reinoud JB, Spillenaar Bilgen, Ernst Jan, Polée, Marco B, Geenen, Maud M, Braak, Jeffrey PBM, Neelis, Karen J, Slingerland, Marije, Jansen, Rob LH, Buijsen, Jeroen, Beeker, Aart, Eijsbouts, Quirijn AJ, Van Riel, Johanna MGH, Rozema, Tom, Van Spronsen, Dick Johan, Meerum Terwogt, Jetske M, Tanis, Bea C, Van der Torren-Conze, Adelheid ME, Van Hilligersberg, Richard, Koopman, Miriam, Den Boer, Marien O, Creemers, Geert-Jan, Van der Sangen, Maurice, Rentinck, Marjolein EM, Van den Berg, H Pieter, Jonkers, Ge JPM, Grootenboers, Diane, Vulink, Annelie JE, Hovenga, Sjoerd, Van der Mijle, Huub CJ, Baars, Arnold, Haringhuizen, Annebeth W, Appels, Marije IE, Rietbroek, Ron C, Hendriksen, Ellen M, Legdeur, Marie-Cecile JC, Ten Bokkel Huinink, Daan, Van Dobbenburgh, O Aart, Smit, Jitty M, Van Bochove, Aart, Veldhuis, Gerrit-Jan, Muller, Erik W, Bonenkamp, J (Han) J, Braam, Pètra M, De Boer, Jaap, Van Halteren, Henk K, Valster, Fransje AA, Imholz, Alex LT, Van Dijk, Marjan A, Van der Gaast, Ate, Otten, J (Hans)-Martin MB, Ceha, Heleen M, Glimelius, Bengt, Lagerbäck, Cecillia, Perman, Mats, Johnsson, Anders, Borg, David, Nielsen, Niels H, Piwowar, Andrzej, Elmlund, Mattias, Hörberg, Helene, Edlund, Per, Johansson, Bengt, Flygare, Petra, Jespersen, Marie Louise

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Solid-Phase Synthesis of 2-Aminothiazoles von Kearney, Patrick C, Fernandez, Monica, Flygare, John A

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Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering von Pillow, Thomas H, Tien, Janet, Parsons-Reponte, Kathryn L, Bhakta, Sunil, Li, Hao, Staben, Leanna R, Li, Guangmin, Chuh, Josefa, Fourie-O’Donohue, Aimee, Darwish, Martine, Yip, Victor, Liu, Luna, Leipold, Douglas D, Su, Dian, Wu, Elmer, Spencer, Susan D, Shen, Ben-Quan, Xu, Keyang, Kozak, Katherine R, Raab, Helga, Vandlen, Richard, Lewis Phillips, Gail D, Scheller, Richard H, Polakis, Paul, Sliwkowski, Mark X, Flygare, John A, Junutula, Jagath R

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