IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease von Geremia, Alessandra, Arancibia-Cárcamo, Carolina V, Fleming, Myles P P, Rust, Nigel, Singh, Baljit, Mortensen, Neil J, Travis, Simon P L, Powrie, Fiona

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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort von Shaw, Dominick E, Sousa, Ana R, Fowler, Stephen J, Fleming, Louise J, Roberts, Graham, Corfield, Julie, Pandis, Ioannis, Bansal, Aruna T, Bel, Elisabeth H, Auffray, Charles, Compton, Chris H, Bisgaard, Hans, Bucchioni, Enrica, Caruso, Massimo, Chanez, Pascal, Dahlén, Barbro, Dahlen, Sven-Erik, Dyson, Kerry, Frey, Urs, Geiser, Thomas, Gerhardsson de Verdier, Maria, Gibeon, David, Guo, Yi-Ke, Hashimoto, Simone, Hedlin, Gunilla, Jeyasingham, Elizabeth, Hekking, Pieter-Paul W, Higenbottam, Tim, Horváth, Ildikó, Knox, Alan J, Krug, Norbert, Erpenbeck, Veit J, Larsson, Lars X, Lazarinis, Nikos, Matthews, John G, Middelveld, Roelinde, Montuschi, Paolo, Musial, Jacek, Myles, David, Pahus, Laurie, Sandström, Thomas, Seibold, Wolfgang, Singer, Florian, Strandberg, Karin, Vestbo, Jorgen, Vissing, Nadja, von Garnier, Christophe, Adcock, Ian M, Wagers, Scott, Rowe, Anthony, Howarth, Peter, Wagener, Ariane H, Djukanovic, Ratko, Sterk, Peter J, Chung, Kian Fan

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Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation von Östling, Jörgen, Ax, Elisabeth, Calvén, Jenny, Thörn, Kristofer, Israelsson, Elisabeth, Öberg, Lisa, Wilson, Susan J., Ward, Jonathan A., Chauhan, Anoop, Sousa, Ana R., De Meulder, Bertrand, Baribaud, Frédéric, Sterk, Peter J., Guo, Yike, Dahlen, Barbro, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Hohlfeld, Jens M., Sandström, Thomas, James, Anna, Hinks, Timothy S.C., Howarth, Peter H., Vaarala, Outi, van Geest, Marleen, Olsson, Henric, Ahmed, H., Auffray, C., Bakke, P., Bansal, A.T., Bates, S., Bel, E.H., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Bucchioni, E., Bush, A., Caruso, M., Chaiboonchoe, A., Chanez, P., Chung, F.K., Corfield, J., D'Amico, A., De Meulder, B., Djukanovic, R., Fichtner, K., Fleming, L.J., Formaggio, E., Frey, U., Goss, V., Guo, Y., Hashimoto, S., Haughney, J., Hekking, P.W., Higenbottam, T., Hohlfeld, J.M., Holweg, C., Horváth, I., James, A.J., Knowles, R., Loza, M.J., Manta, A., Matthews, J.G., Mazein, A., Meiser, A., Middelveld, R.J.M., Miralpeix, M., Montuschi, P., Murray, C.S., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Postle, A., Powel, P., Praticò, G., Riley, J., Roberts, G., Rowe, A., Sandström, T., Schofield, J.P.R., Selby, A., Shaw, D.E., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Aalderen, W.M., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J.

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Pathway discovery using transcriptomic profiles in adult-onset severe asthma von Hekking, Pieter-Paul, Loza, Matt J., Pavlidis, Stelios, de Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Fred, Auffray, Charles, Brinkman, Paul, Lutter, Rene, Bansal, Aruna T., Sousa, Ana R., Bates, Steve A., Pandis, Yannis, Fleming, Louise J., Shaw, Dominique E., Fowler, Stephen J., Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter H., Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko, Adcock, I.M., Auffray, C., Bakke, P., Bansal, A.T., Baribaud, F., Bates, S., Bel, E.H., Bigler, J., Bisgaard, H., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Bucchioni, E., Burg, D., Caruso, M., Chanez, P., Chung, F.K., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., De Meulder, B., Erpenbeck, V.J., Erzen, D., Fichtner, K., Fitch, N., Formaggio, E., Frey, U., Gahlemann, M., Geiser, T., Hashimoto, S., Haughney, J., Hedlin, G., Hohlfeld, J.M., Holweg, C., Horváth, I., Howarth, P., Knowles, R., Krug, N., Lefaudeux, D., Loza, M.J., Lutter, R., Manta, A., Matthews, J.G., Mazein, A., Middelveld, R.J.M., Mores, N., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powel, P., Praticò, G., Valls, M Puig, Rao, N., Riley, J., Roberts, G., Rowe, A., Sandström, T., Seibold, W., Selby, A., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J.

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Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI) von Bel, Elisabeth H, Sousa, Ana, Fleming, Louise, Bush, Andrew, Chung, K Fan, Versnel, Jennifer, Wagener, Ariane H, Wagers, Scott S, Sterk, Peter J, Compton, Chris H

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IL-17–high asthma with features of a psoriasis immunophenotype von Schofield, James P.R., Ward, Jonathan, Montuschi, Paolo, Auffray, Charles, Adcock, Ian M., Howarth, Peter, Vaarala, Outi, Bates, S., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Bucchioni, E., Burg, D., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., Fichtner, K., Fitch, N., Fowler, S.J., Frey, U., Gahlemann, M., Hashimoto, S., Hedlin, G., Knox, A.J., Lutter, R., Middelveld, R.J.M., Mores, N., Myles, D., Pavlidis, S., Rao, M. Puig N., Rowe, A., Sandström, T., Sigmund, R., Singer, F., Sousa, A.R., Sun, K., Thornton, B., van Aalderen, W.M., Vestbo, J., Wilson, S.J., Badorrek, P., Barber, Clair, Batuwitage, Manohara Kanangana, Berton, A., Bochenek, Grazyna, Dahlén, B., De Alba, Jorge, Dekker, Tamara, Dennison, P., Dodson, Paul, Edwards, Jessica, Emma, Rosalia, Flood, Breda, Guillmant-Farry, E., Hewitt, Lorraine, Hu, X., Johnson, K., Klüglich, M., Kots, Maxim, Kuo, Scott, Lambrecht, Bart, Lantz, A.-S., Latzin, P., Lemonnier, N., Lone-Latif, Saeeda, Manta, Alexander, Martin, Jane, Metcalf, Leanne, Mikus, Maria, Monk, Philip, Nething, K., Nicholas, Ben, Niven, R., Nordlund, B., Nsubuga, S., Palkonen, Susanna, Pellet, J., Pennazza, Giorgio, Petrén, Anne, Pink, Sandy, Rahman-Amin, Malayka, Reynolds, Leanne, Robberechts, Martine, Russell, Kirsty, Rutgers, Michael, Santini, G., Saqi, M., Scott, S., Smith, Katherine M., Stephan, S., Strandberg, K., Szentkereszty, M., Tariq, K., Thorsen, Jonathan, van Drunen, C.M., Wetzel, Kristiane, Wiegman, Coen, Yeyasingham, Elizabeth, Zetterquist, W.

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Treatable traits in the European U‐BIOPRED adult asthma cohorts von Simpson, Andrew J., Hekking, Pieter‐Paul, Shaw, Dominick E., Fleming, Louise J., Roberts, Graham, Riley, John H., Bates, Stewart, Sousa, Ana R., Bansal, Aruna T., Pandis, Ioannis, Sun, Kai, Bakke, Per S., Caruso, Massimo, Dahlén, Barbro, Dahlén, Sven‐Erik, Horvath, Ildiko, Krug, Norbert, Montuschi, Paolo, Sandstrom, Thomas, Singer, Florian, Adcock, Ian M., Wagers, Scott S., Djukanovic, Ratko, Chung, Kian Fan, Sterk, Peter J., Fowler, Stephen J., Ahmed, H, Auffray, C, Baribaud, F, Bel, E. H, Bisgaard, H, Bønnelykke, K, Brandsma, J, Brinkman, P, Bucchioni, E, Burg, D, Bush, A, Chaiboonchoe, A, Chanez, P, Compton, C. H, Corfield, J, D'Amico, A, De Meulder, B, Erpenbeck, V. J, Erzen, D, Fichtner, K, Fleming, L. J, Formaggio, E, Frey, U, Gahlemann, M, Geiser, T, Goss, V, Guo, Y, Hashimoto, S, Haughney, J, Hedlin, G, Hekking, P. W, Higenbottam, T, Hohlfeld, J. M, Holweg, C, Horváth, I, Howarth, P, James, A. J, Knowles, R, Knox, A. J, Lefaudeux, D, Lutter, R, Manta, A, Masefield, S, Matthews, J. G, Mazein, A, Meiser, A, Middelveld, R. J. M, Miralpeix, M, Mores, N, Murray, C. S, Myles, D, Pahus, L, Pavlidis, S, Postle, A, Powel, P, Praticò, G, Rao, N, Roberts, A, Roberts, G, Rowe, A, Sandström, T, Schofield, J. P. R, Selby, A, Sigmund, R, Skipp, P. J, Thornton, B, Aalderen, W. M, Geest, M, Vestbo, J, Vissing, N. H, Wagener, A. H, Weiszhart, Z, Wheelock, C. E, Wilson, S. J

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Neoantigen DNA vaccines are safe, feasible, and induce neoantigen-specific immune responses in triple-negative breast cancer patients von Zhang, Xiuli, Goedegebuure, S. Peter, Chen, Michael Y., Mishra, Rashmi, Zhang, Felicia, Yu, Yik Yeung, Singhal, Kartik, Li, Lijin, Gao, Feng, Myers, Nancy B., Vickery, Tammi, Hundal, Jasreet, McLellan, Michael D., Sturmoski, Mark A., Kim, Samuel W., Chen, Ina, Davidson, Jesse T., Sankpal, Narendra V., Myles, Stephanie, Suresh, Rama, Ma, Cynthia X., Foluso, Ademuyiwa, Wang-Gillam, Andrea, Davies, Sherri, Hagemann, Ian S., Mardis, Elaine R., Griffith, Obi, Griffith, Malachi, Miller, Christopher A., Hansen, Ted H., Fleming, Timothy P., Schreiber, Robert D., Gillanders, William E.

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Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation von Versi, Ali, Ivan, Fransiskus Xaverius, Abdel-Aziz, Mahmoud I, Bates, Stewart, Riley, John, Baribaud, Frederic, Kermani, Nazanin Zounemat, Montuschi, Paolo, Dahlen, Sven-Erik, Djukanovic, Ratko, Sterk, Peter, Maitland-Van Der Zee, Anke H, Chotirmall, Sanjay H, Howarth, Peter, Adcock, Ian M, Chung, Kian Fan

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Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux von Perotin, Jeanne-Marie, Schofield, James P R, Wilson, Susan J, Ward, Jonathan, Brandsma, Joost, Strazzeri, Fabio, Bansal, Aruna, Yang, Xian, Rowe, Anthony, Corfield, Julie, Lutter, Rene, Shaw, Dominick E, Bakke, Per S, Caruso, Massimo, Dahlén, Barbro, Fowler, Stephen J, Horváth, Ildikó, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Sun, Kai, Pandis, Ioannis, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Riley, John H, Sousa, Ana R, Dahlen, Sven-Erik, Adcock, Ian M, Chung, Kian Fan, Sterk, Peter J, Skipp, Paul J, Collins, Jane E, Davies, Donna E, Djukanović, Ratko

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Androgen Receptor Is a Non-canonical Inhibitor of Wild-Type and Mutant Estrogen Receptors in Hormone Receptor-Positive Breast Cancers von Ponnusamy, Suriyan, Asemota, Sarah, Schwartzberg, Lee S., Guestini, Fouzia, McNamara, Keely M., Pierobon, Mariaelena, Font-Tello, Alba, Qiu, Xintao, Xie, Yingtian, Rao, Prakash K., Thiyagarajan, Thirumagal, Grimes, Brandy, Johnson, Daniel L., Fleming, Martin D., Pritchard, Frances E., Berry, Michael P., Oswaks, Roy, Fine, Richard E., Brown, Myles, Sasano, Hironobu, Petricoin, Emanuel F., Long, Henry W., Narayanan, Ramesh

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Carcinoid tumors of the rectum: a multi-institutional international collaboration von Shields, Conor J, Tiret, Emmanuel, Winter, Desmond C

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Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status von Cruz, Alvaro A., Riley, John H., Bansal, Aruna T., Souza-Machado, Adelmir, Almeida, Paula C.A., Biao-Lima, Valmar, Bates, Stewart, Adcock, Ian M., Sterk, Peter J., Araujo, M.I., Barnes, K.C., Belitardo, E., Bião-Lima, V., Cardoso, L., Camargos, P.A., Chatkin, J.M., Costa, R.S., Coelho, A.C.C., Cooper, P.J., Cruz, A.A., Cruz, C.S., Cunha, J., de Jesus, J.V., Gomes-Filho, I., Lima-Matos, A., Figueiredo, C.A., Lessa, M.A., Muniz, I.S., Pinheiro, G.P., Ponte, E.V., Santana, C.V.N., Santos-Lima, G., Souza, T.M.O., Souza-Machado, A., Stelmach, R., Vasquez, V.S., Adcock, I.M., Ahmed, H., Bakke, P., Baribaud, F., Bel, E.H., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brinkman, P., Bucchioni, E., Caruso, M., Chaiboonchoe, A., Chanez, P., Compton, C.H., D'Amico, A., Dahlén, S.E., De Meulder, B., Djukanovic, R., Erpenbeck, V.J., Fichtner, K., Fitch, N., Fleming, L.J., Formaggio, E., Frey, U., Gahlemann, M., Goss, V., Hedlin, G., Hekking, P.W., Higenbottam, T., Hohlfeld, J.M., Holweg, C., James, A.J., Knox, A.J., Krug, N., Lefaudeux, D., Loza, M.J., Lutter, R., Manta, A., Masefield, S., Matthews, J.G., Middelveld, R.J.M., Montuschi, P., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powel, P., Puig Valls, M., Rao, N., Roberts, G., Rowe, A., Sandström, T., Schofield, J.P.R., Selby, A., Shaw, D.E., Sigmund, R., Singer, F., Sun, K., Thornton, B., van Aalderen, W.M., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wilson, S.J.

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Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study von Kolmert, Johan, Gómez, Cristina, Balgoma, David, Sjödin, Marcus, Bood, Johan, Konradsen, Jon R, Ericsson, Magnus, Thörngren, John-Olof, James, Anna, Mikus, Maria, Sousa, Ana R, Riley, John H, Bates, Stewart, Bakke, Per S, Pandis, Ioannis, Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J, Geiser, Thomas, Howarth, Peter, Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Behndig, Annelie, Shaw, Dominick E, Knowles, Richard G, Holweg, Cécile T J, Wheelock, Åsa M, Dahlén, Barbro, Nordlund, Björn, Alving, Kjell, Hedlin, Gunilla, Chung, Kian Fan, Adcock, Ian M, Sterk, Peter J, Djukanovic, Ratko, Dahlén, Sven-Erik, Wheelock, Craig E

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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort (vol 46, pg 1308, 2015) von Shaw, DE, Sousa, AR, Fowler, SJ, Fleming, LJ, Roberts, G, Corfield, J, Pandis, I, Bansal, AT, Bel, EH, Auffray, C, Compton, CH, Bisgaard, H, Bucchioni, E, Caruso, M, Chanez, P, Dahlen, B, Dahlen, SE, Dyson, K, Frey, U, Geiser, T, de Verdier, MG, Gibeon, D, Guo, YK, Hashimoto, S, Hedlin, G, Jeyasingham, E, Hekking, PPW, Higenbottam, T, Horvath, I, Knox, AJ, Krug, N, Erpenbeck, VJ, Larsson, LX, Lazarinis, N, Matthews, JG, Middelveld, R, Montuschi, P, Musial, J, Myles, D, Pahus, L, Sandstrom, T, Seibold, W, Singer, F, Strandberg, K, Vestbo, J, Vissing, N, von Garnier, C, Adcock, IM, Wagers, S, Rowe, A, Howarth, P, Wagener, AH, Djukanovic, R, Sterk, PJ, Chung, KF

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Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers von Brandsma, Joost, Goss, Victoria M., Yang, Xian, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Dahlén, Sven-Erik, Fowler, Stephen J., Horvath, Ildiko, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Shaw, Dominick E., Chung, Kian Fan, Singer, Florian, Fleming, Louise J., Sousa, Ana R., Pandis, Ioannis, Bansal, Aruna T., Sterk, Peter J., Djukanović, Ratko, Postle, Anthony D.

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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort von Shaw, DE, Sousa, AR, Fowler, SJ, Fleming, LJ, Roberts, G, Corfield, J, Pandis, I, Bansal, AT, Bel, EH, Auffray, C, Compton, CH, Bisgaard, H, Bucchioni, E, Caruso, M, Chanez, P, Dahlen, B, Dahlen, S-E, Dyson, K, Frey, U, Geiser, T, De Verdier, MG, Gibeon, D, Guo, Y-K, Hashimoto, S, Hedlin, G, Jeyasingham, E, Hekking, P-PW, Higenbottam, T, Horvath, I, Knox, AJ, Krug, N, Erpenbeck, VJ, Larsson, LX, Lazarinis, N, Matthews, JG, Middelveld, R, Montuschi, P, Musial, J, Myles, D, Pahus, L, Sandstrom, T, Seibold, W, Singer, F, Strandberg, K, Vestbo, J, Vissing, N, Von Garnier, C, Adcock, IM, Wagers, S, Rowe, A, Howarth, P, Wagener, AH, Djukanovic, R, Sterk, PJ, Chung, KF

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C38 BIOMARKERS OF ACUTE AND CHRONIC INFLAMMATION: Prevalence Of Gastro-Oesophageal Reflux (gord) And Associations With Clinical Phenotypic Markers In Adult Severe Asthmatics In The... von Tariq, K, Nicholas, B L, Lutter, R, Bel, E, Bansal, A, Wagers, S S, Bisgaard, H, Sandstrom, T, Larsson, L, Vestbo, J, Montuschi, P, Higgenbottam, T W, Compton, C, Myles, D, Chanez, P, Pahus, L, Murray, C S, Woodcock, A, Musial, J, Nordlund, B, Hashimoto, S, Hedlin, G L, Dahlen, S-E K, Middelveld, R, DAHLEN, B, Krug, N, Vissing, N, Polosa, R, Horvath, I, Singer, F, Bakke, P, Roberts, G, Fichtner, K, Rowe, A, Jeyasingham, E, Riley, J, Fleming, L, Fowler, S J, Shaw, D E, Corfield, J, Sousa, A R, Chung, K, Howarth, P H, Sterk, P J, Djukanovic, R

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B13 MECHANISMS AND TREATMENT CONSIDERATIONS FOR SEVERE ASTHMA: Severe Asthma Patients On Oral Corticosteroid Therapy As A Distinct Phenotype: The European U-Biopred Cohort von Chung, K F, Gibeon, D, Sousa, A R, Corfield, J, Shaw, D E, Fowler, S J, Fleming, L J, Riley, J, Jeyasingham, E, Rowe, A, Fichtner, K, Roberts, G, Bakke, P, Von Garnier, C, Horvath, I, Riccardo, P, Krug, N, Dahlen, B, Musial, J, Pahus, L, Myles, D, Compton, C, Higenbottam, T W, Montuschi, P, Larsson, L, Sandstrom, T, Wagers, S S, Howarth, P H, Bel, E, Bansal, A T, Djukanovic, R, Sterk, P J

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B101 ASTHMA PATHOGENESIS: Prevalence And Phenotypic Characteristics Of Severe Adult-Onset Asthma In The U-Biopred Cohort von Hekking, P-P, Wagener, A H, Sousa, A R, Fowler, S J, Bakke, P, Frey, U, Krug, N, Hashimoto, S, Woodcock, A, Chanez, P, Montuschi, P, Bisgaard, H, Corfield, J, Howarth, P H, Djukanovic, R, Chung, K, Fleming, L, Riley, J, Jeyasingham, E, Fichtner, K, Rowe, A, Roberts, G, Singer, F, Geiser, T, Horvath, I, Polosa, R, Vissing, N, Dahlen, B, Musial, J, Murray, C, Myles, D, Compton, C, Higenbottam, T W, Vestbo, J, Pahus, L, Larsson, L, Sandstrom, T, Shaw, D, Wagers, S S, Sterk, P J, Bansal, A T, Bel, E

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