Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro von PATEL, Anand G, DE LORENZO, Silvana B, FLATTEN, Karen S, POIRIER, Guy G, KAUFMANN, Scott H

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ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status von HUNTOON, Catherine J, FLATTEN, Karen S, WAHNER HENDRICKSON, Andrea E, HUEHLS, Amelia M, SUTOR, Shari L, KAUFMANN, Scott H, KARNITZ, Larry M

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A phase I study of pevonedistat, azacitidine, and venetoclax in patients with relapsed/refractory acute myeloid leukemia von Murthy, Guru Subramanian Guru, Saliba, Antoine N, Szabo, Aniko, Harrington, Alexandra, Abedin, Sameem, Carlson, Karen, Michaelis, Laura, Runaas, Lyndsey, Baim, Arielle, Hinman, Alex, Maldonado-Schmidt, Sonia, Venkatachalam, Annapoorna, Flatten, Karen S, Peterson, Kevin L, Schneider, Paula A, Litzow, Mark, Kaufmann, Scott H, Atallah, Ehab

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Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells von Schroeder, Barbara, Vander Steen, Travis, Espinoza, Ingrid, Venkatapoorna, Chandra M. Kurapaty, Hu, Zeng, Silva, Fernando Martín, Regan, Kevin, Cuyàs, Elisabet, Meng, X. Wei, Verdura, Sara, Arbusà, Aina, Schneider, Paula A., Flatten, Karen S., Kemble, George, Montero, Joan, Kaufmann, Scott H., Menendez, Javier A., Lupu, Ruth

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Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis von Maskey, Reeja S, Flatten, Karen S, Sieben, Cynthia J, Peterson, Kevin L, Baker, Darren J, Nam, Hyun-Ja, Kim, Myoung Shin, Smyrk, Thomas C, Kojima, Yusuke, Machida, Yuka, Santiago, Annyoceli, van Deursen, Jan M, Kaufmann, Scott H, Machida, Yuichi J

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A BAK subdomain that binds mitochondrial lipids selectively and releases cytochrome C von Dai, Haiming, Peterson, Kevin L., Flatten, Karen S., Meng, X. Wei, Venkatachalam, Annapoorna, Correia, Cristina, Ramirez-Alvarado, Marina, Pang, Yuan-Ping, Kaufmann, Scott H.

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Immunodetection of human topoisomerase I-DNA covalent complexes von Patel, Anand G, Flatten, Karen S, Peterson, Kevin L, Beito, Thomas G, Schneider, Paula A, Perkins, Angela L, Harki, Daniel A, Kaufmann, Scott H

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Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes von Patel, Anand G., Flatten, Karen S., Schneider, Paula A., Dai, Nga T., McDonald, Jennifer S., Poirier, Guy G., Kaufmann, Scott H.

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Proapoptotic activity of JNK-sensitive BH3-only proteins underpins ovarian cancer response to replication checkpoint inhibitors von Venkatachalam, Annapoorna, Correia, Cristina, Peterson, Kevin L, Hou, Xianon, Schneider, Paula A, Strathman, Annabella R, Flatten, Karen S, Sine, Chance C, Balczewski, Emily A, McGehee, Cordelia D, Larson, Melissa C, Duffield, Laura N, Meng, X Wei, Vincelette, Nicole D, Ding, Husheng, Oberg, Ann L, Couch, Fergus J, Swisher, Elizabeth M, Li, Hu, Weroha, S John, Kaufmann, Scott H

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53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer von Hurley, Rachel M., Wahner Hendrickson, Andrea E., Visscher, Daniel W., Ansell, Peter, Harrell, Maria I., Wagner, Jill M., Negron, Vivian, Goergen, Krista M., Maurer, Matthew J., Oberg, Ann L., Meng, X. Wei, Flatten, Karen S., De Jonge, Maja J.A., Van Herpen, Carla D., Gietema, Jourik A., Koornstra, Rutger H.T., Jager, Agnes, den Hollander, Martha W., Dudley, Matthew, Shepherd, Stacie P., Swisher, Elizabeth M., Kaufmann, Scott H.

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CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo von Chaudhuri, Leena, Vincelette, Nicole D, Koh, Brian D, Naylor, Ryan M, Flatten, Karen S, Peterson, Kevin L, McNally, Amanda, Gojo, Ivana, Karp, Judith E, Mesa, Ruben A, Sproat, Lisa O, Bogenberger, James M, Kaufmann, Scott H, Tibes, Raoul

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AMPK inhibition sensitizes acute leukemia cells to BH3 mimetic-induced cell death von Jia, Jia, Ji, Wenbo, Saliba, Antoine N., Csizmar, Clifford M., Ye, Kaiqin, Hu, Lei, Peterson, Kevin L., Schneider, Paula A., Meng, X. Wei, Venkatachalam, Annapoorna, Patnaik, Mrinal M., Webster, Jonathan A., Smith, B. Douglas, Ghiaur, Gabriel, Wu, Xinyan, Zhong, Jun, Pandey, Akhilesh, Flatten, Karen S., Deng, Qingmei, Wang, Hongzhi, Kaufmann, Scott H., Dai, Haiming

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A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors von Wahner Hendrickson, Andrea E, Menefee, Michael E, Hartmann, Lynn C, Long, Harry J, Northfelt, Donald W, Reid, Joel M, Boakye-Agyeman, Felix, Kayode, Olumide, Flatten, Karen S, Harrell, Maria I, Swisher, Elizabeth M, Poirier, Guy G, Satele, Daniel, Allred, Jake, Lensing, Janet L, Chen, Alice, Ji, Jiuping, Zang, Yiping, Erlichman, Charles, Haluska, Paul, Kaufmann, Scott H

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Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies von Gupta, Mamta, Hendrickson, Andrea E. Wahner, Yun, Seong Seok, Han, Jing Jing, Schneider, Paula A., Koh, Brian D., Stenson, Mary J., Wellik, Linda E., Shing, Jennifer C., Peterson, Kevin L., Flatten, Karen S., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Barr, Sharon, Witzig, Thomas E., Kaufmann, Scott H.

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Phase I and Pharmacologic Trial of Cytosine Arabinoside with the Selective Checkpoint 1 Inhibitor Sch 900776 in Refractory Acute Leukemias von KARP, Judith E, THOMAS, Brian M, MACKEY, Karen, FRESHWATER, Tomoko, LEVIS, Mark J, MCDEVITT, Michael A, CARRAWAY, Hetty E, GLADSTONE, Douglas E, SHOWEL, Margaret M, LOECHNER, Sabine, PARRY, David A, HOROWITZ, Jo Ann, GREER, Jacqueline M, ISAACS, Randi, KAUFMANN, Scott H, SORGE, Christopher, GORE, Steven D, PRATZ, Keith W, DOUGLAS SMITH, B, FLATTEN, Karen S, PETERSON, Kevin, SCHNEIDER, Paula

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In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma von AlHilli, Mariam M, Becker, Marc A, Weroha, S. John, Flatten, Karen S, Hurley, Rachel M, Harrell, Maria I, Oberg, Ann L, Maurer, Matt J, Hawthorne, Kieran M, Hou, Xiaonan, Harrington, Sean C, McKinstry, Sarah, Meng, X. Wei, Wilcoxen, Keith M, Kalli, Kimberly R, Swisher, Elizabeth M, Kaufmann, Scott H, Haluska, Paul

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Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression von Meng, X.Wei, Koh, Brian D., Zhang, Jin-San, Flatten, Karen S., Schneider, Paula A., Billadeau, Daniel D., Hess, Allan D., Smith, B.Douglas, Karp, Judith E., Kaufmann, Scott H.

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4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells von Yun, Seongseok, Vincelette, Nicole D., Knorr, Katherine L.B., Almada, Luciana L., Schneider, Paula A., Peterson, Kevin L., Flatten, Karen S., Dai, Haiming, Pratz, Keith W., Hess, Allan D., Smith, B.Douglas, Karp, Judith E., Hendrickson, Andrea E.Wahner, Fernandez-Zapico, Martin E., Kaufmann, Scott H.

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Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway von HUNTOON, Catherine J, NYE, Monica D, LIYI GENG, PETERSON, Kevin L, FLATTEN, Karen S, HALUSKA, Paul, KAUFMANN, Scott H, KARNITZ, Larry M

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CDK2-Mediated Upregulation of TNF alpha as a Mechanism of Selective Cytotoxicity in Acute Leukemia von Ding, Husheng, Vincelette, Nicole D., McGehee, Cordelia D., Kohorst, Mira A., Koh, Brian D., Venkatachalam, Annapoorna, Meng, X. Wei, Schneider, Paula A., Flatten, Karen S., Peterson, Kevin L., Correia, Cristina, Lee, Sun-Hee, Patnaik, Mrinal, Webster, Jonathan A., Ghiaur, Gabriel, Smith, B. Douglas, Karp, Judith E., Pratz, Keith W., Li, Hu, Karnitz, Larry M., Kaufmann, Scott H.

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