Understanding the cellular origin and progression of esophageal cancer using esophageal organoids von Sachdeva, Uma M., Shimonosono, Masataka, Flashner, Samuel, Cruz-Acuña, Ricardo, Gabre, Joel T., Nakagawa, Hiroshi

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Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus von Doyle, Alfred D., Masuda, Mia Y., Pyon, Grace C., Luo, Huijun, Putikova, Arina, LeSuer, William E., Flashner, Samuel, Rank, Matthew A., Nakagawa, Hiroshi, Kita, Hirohito, Wright, Benjamin L.

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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1 von Swift, Michelle L., Beishline, Kate, Flashner, Samuel, Azizkhan-Clifford, Jane

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Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation von Mucha, Bartosz, Qie, Shuo, Bajpai, Sagar, Tarallo, Vincenzo, Diehl, J. Nathaniel, Tedeschi, Frank, Zhou, Gao, Gao, Zhaofeng, Flashner, Samuel, Klein-Szanto, Andres J., Hibshoosh, Hanina, Masataka, Shimonosono, Chajewski, Olga S., Majsterek, Ireneusz, Pytel, Dariusz, Hatzoglou, Maria, Der, Channing J., Nakagawa, Hiroshi, Bass, Adam J., Wong, Kwok-Kin, Fuchs, Serge Y., Rustgi, Anil K., Jankowsky, Eckhard, Diehl, J. Alan

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3D Organoids: An Untapped Platform for Studying Host-Microbiome Interactions in Esophageal Cancers von Flashner, Samuel, Yan, Kelley S., Nakagawa, Hiroshi

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Lactate Suppresses Growth of Esophageal Adenocarcinoma Patient-Derived Organoids through Alterations in Tumor NADH/NAD+ Redox State von Su, Steven H, Mitani, Yosuke, Li, Tianxia, Sachdeva, Uma, Flashner, Samuel, Klein-Szanto, Andres, Dunbar, Karen J, Abrams, Julian, Nakagawa, Hiroshi, Gabre, Joel

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Protocol for tumor dissociation and fluorescence-activated cell sorting of human head and neck cancers von Okolo, Ogoegbunam, Yu, Victoria, Flashner, Samuel, Martin, Cecilia, Nakagawa, Hiroshi, Lin, Derrick T., Puram, Sidharth V., Parikh, Anuraag S.

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Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids von Shimonosono, Masataka, Morimoto, Masaki, Hirose, Wataru, Tomita, Yasuto, Matsuura, Norihiro, Flashner, Samuel, Ebadi, Mesra S, Okayasu, Emilea H, Lee, Christian Y, Britton, William R, Martin, Cecilia, Wuertz, Beverly R, Parikh, Anuraag S, Sachdeva, Uma M, Ondrey, Frank G, Atigadda, Venkatram R, Elmets, Craig A, Abrams, Julian A, Muir, Amanda B, Klein-Szanto, Andres J, Weinberg, Kenneth I, Momen-Heravi, Fatemeh, Nakagawa, Hiroshi

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Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy von Shimonosono, Masataka, Tanaka, Koji, Flashner, Samuel, Takada, Satoshi, Matsuura, Norihiro, Tomita, Yasuto, Sachdeva, Uma M., Noguchi, Eishi, Sangwan, Veena, Ferri, Lorenzo, Momen-Heravi, Fatemeh, Yoon, Angela J., Klein-Szanto, Andres J., Diehl, J. Alan, Nakagawa, Hiroshi

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Transcription factor Sp1 regulates mitotic chromosome assembly and segregation von Flashner, Samuel, Swift, Michelle, Sowash, Aislinn, Fahmy, Alexander N., Azizkhan-Clifford, Jane

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Oral detergent exposure alters the esophageal microbiome and induces eosinophilic inflammation von Wright, Benjamin, Masuda, Mia, Flashner, Samuel, Gibson, Jessica, Luo, Huijun, Putikova, Arina, Pyon, Grace, Rank, Matthew, Nakagawa, Hiroshi, Kita, Hirohito, Cope, Emily, Doyle, Alfred

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Caspase cleavage of transcription factor Sp1 enhances apoptosis von Torabi, Behzad, Flashner, Samuel, Beishline, Kate, Sowash, Aislinn, Donovan, Kelly, Bassett, Garrett, Azizkhan-Clifford, Jane

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779 EOSINOPHILIC ESOPHAGITIS - RELATED BASAL CELL HYPERPLASIA IS ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION REVERSIBLE BY OMEPRAZOLE von Morimoto, Masaki, Tomita, Yasuto, Flashner, Samuel, Martin, Cecilia, Okayasu, Emilea H., Ebadi, Mesra, Wang, Joshua X., Doyle, Alfred D., Wright, Benjamin L., Whelan, Kelly A., Que, Jianwen, Muir, Amanda B., Nakagawa, Hiroshi, Sachdeva, Uma M.

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Su1290 NOTCH SIGNALING MAY PROTECT AGAINST BASAL CELL HYPERPLASIA UNDER EOSINOPHILIC ESOPHAGITIS von Morimoto, Masaki, Hirose, Wataru, Flashner, Samuel, Okayasu, Emilea H., Lee, Christian, Ebadi, Mesra, Martin, Cecilia, Wang, Joshua X., Doyle, Alfred D., Wright, Benjamin L., Muir, Amanda B., Nakagawa, Hiroshi

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Sa1186: INDUCIBLE EXPRESSION OF IL-33 FROM THE BASAL EPITHELIUM ELICITS ESOPHAGEAL AND EPIDERMAL HYPERPLASIA AND TYPE 2 INFLAMMATION von Doyle, Alfred D., Pyon, Grace, Masuda, Mia Y., Luo, Huijun, LeSuer, William, Kita, Hirohito, Flashner, Samuel, Nakagawa, Hiroshi, Wright, Benjamin L.

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Su1240 LACTATE SUPRESSES GROWTH OF BARRETT'S ESOPHAGUS AND ESOPHAGEAL ADENOCARCNIOMA PATIENT DERIVED ORGANOIDS von Su, Steven H., Gabre, Joel T., Sachdeva, Uma M., Flashner, Samuel, Solfisburg, Quinn S., Baldini, Federico, Klein-Szanto, Andres, Wang, Timothy C., Rustgi, Anil K., Korem, Tal, Abrams, Julian A., Nakagawa, Hiroshi

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Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13 von Masuda, Mia Y., Pyon, Grace C., Luo, Huijun, LeSuer, William E., Putikova, Arina, Dao, Adelyn, Ortiz, Danna R., Schulze, Aliviya R., Fritz, Nicholas, Kobayashi, Takao, Iijima, Koji, Klein-Szanto, Andres J., Shimonosono, Masataka, Flashner, Samuel, Morimoto, Masaki, Pai, Rish K., Rank, Matthew A., Nakagawa, Hiroshi, Kita, Hirohito, Wright, Benjamin L., Doyle, Alfred D.

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Patient-derived three-dimensional culture techniques model tumor heterogeneity in head and neck cancer von Parikh, Anuraag S., Yu, Victoria X., Flashner, Samuel, Okolo, Ogoegbunam B., Lu, Chao, Henick, Brian S., Momen-Heravi, Fatemeh, Puram, Sidharth V., Teknos, Theodoros, Pan, Quintin, Nakagawa, Hiroshi

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Experimental Modeling of Host-Bacterial Interactions in Head and Neck Squamous Cell Carcinoma von Okolo, Ogoegbunam, Honzel, Emily, Britton, William R, Yu, Victoria X, Flashner, Samuel, Martin, Cecilia, Nakagawa, Hiroshi, Parikh, Anuraag S

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Abstract 3082: Leveraging 3D organoids to identify molecular changes underlying HNSC initiation and development von Agee, Robert, Flashner, Samuel, Shimonosono, Masataka, Klein-Szanto, Andres, Nakagawa, Hiroshi

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