Bacterial carbonic anhydrases: underexploited antibacterial therapeutic targets von Flaherty, Daniel P., Seleem, Mohamed N., Supuran, Claudiu T.

Volltext

Coumarins effectively inhibit bacterial α-carbonic anhydrases von Giovannuzzi, Simone, Hewitt, Chad S., Nocentini, Alessio, Capasso, Clemente, Flaherty, Daniel P., Supuran, Claudiu T.

Volltext

Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae von Abutaleb, Nader S., Elhassanny, Ahmed E. M., Nocentini, Alessio, Hewitt, Chad S., Elkashif, Ahmed, Cooper, Bruce R., Supuran, Claudiu T., Seleem, Mohamed N., Flaherty, Daniel P.

Volltext

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells von Lopez-Sambrooks, Cecilia, Shrimal, Shiteshu, Khodier, Carol, Flaherty, Daniel P, Rinis, Natalie, Charest, Jonathan C, Gao, Ningguo, Zhao, Peng, Wells, Lance, Lewis, Timothy A, Lehrman, Mark A, Gilmore, Reid, Golden, Jennifer E, Contessa, Joseph N

Volltext

Inhibition studies of bacterial α-carbonic anhydrases with phenols von Giovannuzzi, Simone, Hewitt, Chad S, Nocentini, Alessio, Capasso, Clemente, Costantino, Gabriele, Flaherty, Daniel P, Supuran, Claudiu T

Volltext

Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae von Giovannuzzi, Simone, Abutaleb, Nader S., Hewitt, Chad S., Carta, Fabrizio, Nocentini, Alessio, Seleem, Mohamed N., Flaherty, Daniel P., Supuran, Claudiu T.

Volltext

Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae von Nocentini, Alessio, Hewitt, Chad S., Mastrolorenzo, Margaret D., Flaherty, Daniel P., Supuran, Claudiu T.

Volltext

Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases von An, Weiwei, Holly, Katrina J., Nocentini, Alessio, Imhoff, Ryan D., Hewitt, Chad. S., Abutaleb, Nader S., Cao, Xufeng, Seleem, Mohamed N., Supuran, Claudiu T., Flaherty, Daniel P.

Volltext

In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci von Abutaleb, Nader S., Elhassanny, Ahmed E. M., Flaherty, Daniel P., Seleem, Mohamed N.

Volltext

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype von Dwyer, Tiffany S, O'Brien, Joseph B, Ptak, Christopher P, LaVigne, Justin E, Flaherty, Daniel P, Watts, Val J, Roman, David L

Volltext

Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates von Giovannuzzi, Simone, Marapaka, Anil Kumar, Abutaleb, Nader S, Carta, Fabrizio, Liang, Hsin-Wen, Nocentini, Alessio, Pisano, Luigi, Seleem, Mohamed N, Flaherty, Daniel P, Supuran, Claudiu T

Volltext

Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3 von Hewitt, Chad S, Das, Chittaranjan, Flaherty, Daniel P

Volltext

Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1 von Krabill, Aaron D., Chen, Hao, Hussain, Sajjad, Hewitt, Chad S., Imhoff, Ryan D., Muli, Christine S., Das, Chittaranjan, Galardy, Paul J., Wendt, Michael K., Flaherty, Daniel P.

Volltext

Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus von Perlmutter, Jessamyn I, Forbes, Lauren T, Krysan, Damian J, Ebsworth-Mojica, Katherine, Colquhoun, Jennifer M, Wang, Jenna L, Dunman, Paul M, Flaherty, Daniel P

Volltext

Congruent Release of Drug and Polymer from Amorphous Solid Dispersions: Insights into the Role of Drug-Polymer Hydrogen Bonding, Surface Crystallization, and Glass Transition von Saboo, Sugandha, Kestur, Umesh S, Flaherty, Daniel P, Taylor, Lynne S

Volltext

Carbonic Anhydrase Inhibition as a Target for Antibiotic Synergy in Enterococci von Chilambi, Gayatri Shankar, Wang, Yu-Hao, Wallace, Nathan R, Obiwuma, Chetachukwu, Evans, Kirsten M, Li, Yanhong, Shalaby, Menna-Allah W, Flaherty, Daniel P, Shields, Ryan K, Doi, Yohei, Van Tyne, Daria

Volltext

Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA von Chojnacki, Michaelle, Cao, Xufeng, Flaherty, Daniel P., Dunman, Paul M.

Volltext

In Vivo Antibacterial Activity of Acetazolamide von Abutaleb, Nader S., Elkashif, Ahmed, Flaherty, Daniel P., Seleem, Mohamed N.

Volltext

Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase von HARRIS, Michael T, WALKER, Dawn M, DREW, Mark E, MITCHELL, William G, KEVIN DAO, SCHROEDER, Chad E, FLAHERTY, Daniel P, WEINER, Warren S, GOLDEN, Jennifer E, MORRIS, James C

Volltext

Biochemical pharmacology of adenylyl cyclases in cancer von Chandra Jena, Bikash, Flaherty, Daniel P., O'Brien, Valerie P., Watts, Val J.

Volltext