Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia von Ariazi, Jennifer L., Duffy, Kevin J., Adams, David F., Fitch, Duke M., Luo, Lusong, Pappalardi, Melissa, Biju, Mangatt, DiFilippo, Erin Hugger, Shaw, Tony, Wiggall, Ken, Erickson-Miller, Connie

Volltext

Application of Complex Aldol Reactions to the Total Synthesis of Phorboxazole B von Evans, David A, Fitch, Duke M, Smith, Thomas E, Cee, Victor J

Volltext

3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase von Tedesco, Rosanna, Shaw, Antony N, Bambal, Ramesh, Chai, Deping, Concha, Nestor O, Darcy, Michael G, Dhanak, Dashyant, Fitch, Duke M, Gates, Adam, Gerhardt, Warren G, Halegoua, Dina L, Han, Chao, Hofmann, Glenn A, Johnston, Victor K, Kaura, Arun C, Liu, Nannan, Keenan, Richard M, Lin-Goerke, Juili, Sarisky, Robert T, Wiggall, Kenneth J, Zimmerman, Michael N, Duffy, Kevin J

Volltext

Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase von Shaw, Antony N., Tedesco, Rosanna, Bambal, Ramesh, Chai, Deping, Concha, Nestor O., Darcy, Michael G., Dhanak, Dashyant, Duffy, Kevin J., Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Liu, Nannan, Sarisky, Robert T., Wiggall, Kenneth J., Zimmerman, Michael N.

Volltext

A Highly Efficient, Asymmetric Synthesis of Benzothiadiazine-Substituted Tetramic Acids:  Potent Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase von Fitch, Duke M, Evans, Karen A, Chai, Deping, Duffy, Kevin J

Volltext

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors von Tedesco, Rosanna, Chai, Deping, Darcy, Michael G., Dhanak, Dashyant, Fitch, Duke M., Gates, Adam, Johnston, Victor K., Keenan, Richard M., Lin-Goerke, Juili, Sarisky, Robert T., Shaw, Antony N., Valko, Klara L., Wiggall, Kenneth J., Zimmerman, Michael N., Duffy, Kevin J.

Volltext

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295 von Qian, Xiangping, McDonald, Andrew, Zhou, Han-Jie, Adams, Nicholas D, Parrish, Cynthia A, Duffy, Kevin J, Fitch, Duke M, Tedesco, Rosanna, Ashcraft, Luke W, Yao, Bing, Jiang, Hong, Huang, Jennifer K, Marin, Melchor V, Aroyan, Carrie E, Wang, Jianchao, Ahmed, Seyed, Burgess, Joelle L, Chaudhari, Amita M, Donatelli, Carla A, Darcy, Michael G, Ridgers, Lance H, Newlander, Ken A, Schmidt, Stanley J, Chai, Deping, Colón, Mariela, Zimmerman, Michael N, Lad, Latesh, Sakowicz, Roman, Schauer, Stephen, Belmont, Lisa, Baliga, Ramesh, Pierce, Daniel W, Finer, Jeffrey T, Wang, Zhengping, Morgan, Bradley P, Morgans, David J, Auger, Kurt R, Sung, Chiu-Mei, Carson, Jeff D, Luo, Lusong, Hugger, Erin D, Copeland, Robert A, Sutton, David, Elliott, John D, Jackson, Jeffrey R, Wood, Kenneth W, Dhanak, Dashyant, Bergnes, Gustave, Knight, Steven D

Volltext

Tremorgenic Indole Alkaloids. 9. Asymmetric construction of an Advanced F-G-H-ring Lactone precursor for the Synthesis of Penitrem D von Smith, Amos B, Nolen, Ernest G, Shirai, Ryuichi, Blase, Frances R, Ohta, Mitsuaki, Chida, Noritaka, Hartz, Richard A, Fitch, Duke M, Clark, William M, Sprengeler, Paul A

Volltext

Enantioselective Synthesis of the Elaiophylin Aglycon von Evans, David A, Fitch, Duke M

Volltext

Asymmetric Synthesis of Phorboxazole B-Part II: Synthesis of the C1-C19 Subunit and Fragment Assembly von Evans, David A., Fitch, Duke M.

Volltext

Asymmetric Synthesis of Phorboxazole B-Part I: Synthesis of the C20-C38 and C39-C46 Subunits von Evans, David A., Cee, Victor J., Smith, Thomas E., Fitch, Duke M., Cho, Patricia S.

Volltext

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzo-thiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitor... von TEDESCO, Rosanna, DEPING CHAI, SHAW, Antony N, VALKO, Klara L, WIGGALL, Kenneth J, ZIMMERMAN, Michael N, DUFFY, Kevin J, DARCY, Michael G, DHANAK, Dashyant, FITCH, Duke M, GATES, Adam, JOHNSTON, Victor K, KEENAN, Richard M, LIN-GOERKE, Juili, SARISKY, Robert T

Volltext

GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia von Erickson-Miller, Connie L., Creasy, Caretha, Chadderton, Antony, Hopson, Christopher B., Valoret, Elizabeth I., Gorczyca, Michele, Elefante, Louis, Wojchowski, Don M., Chomo, Matthew, Fitch, Duke M., Duffy, Kevin J.

Volltext

Prolyl Hydroxylase Inhibitors von DUFFY, Kevin J, SHAW, Antony N, WIGGALL, Kenneth, JIN, Jian, LIU, Ronggang, FITCH, Duke M

Volltext bestellen

Prolyl hydroxylase inhibitors von Jin, Jian, Fitch, Duke M, Liu, Ronggang, Duffy, Kevin J, Wiggall, Kenneth, Shaw, Antony N

Volltext bestellen

Prolyl Hydroxylase Inhibitors von Duffy, Kevin J, SHAW, Antony N, WIGGALL, Kenneth, JIN, Jian, LIU, Ronggang, FITCH, Duke M

Volltext bestellen

Prolyl hydroxylase inhibitors von Fitch, Duke M, Wiggall, Kenneth, Shaw, Antony N

Volltext bestellen

Prolyl Hydroxylase Inhibitors von Fitch, Duke M, Wiggall, Kenneth, Shaw, Antony N

Volltext bestellen

Prolyl hydroxylase inhibitors von Fitch, Duke M, Wiggall, Kenneth, Shaw, Antony N

Volltext bestellen

Prolyl Hydroxylase Inhibitors von DUFFY, Kevin J, SHAW, Antony N, WIGGALL, Kenneth, JIN, Jian, LIU, Ronggang, FITCH, Duke M

Volltext bestellen