Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML von Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A., Liang, Yanke, Wang, Eric S., Nowak, Radosław P., Yuan, Jingting C., Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C., Fischer, Eric S., Gray, Nathanael S., Winter, Georg E.

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Plasticity in binding confers selectivity in ligand-induced protein degradation von Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.

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Targeted protein degradation as a powerful research tool in basic biology and drug target discovery von Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah E., Nowak, Radosław P., Fischer, Eric S.

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Bruton tyrosine kinase degradation as a therapeutic strategy for cancer von Dobrovolsky, Dennis, Wang, Eric S., Morrow, Sara, Leahy, Catharine, Faust, Tyler, Nowak, Radosław P., Donovan, Katherine A., Yang, Guang, Li, Zhengnian, Fischer, Eric S., Treon, Steven P., Weinstock, David M., Gray, Nathanael S.

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation von Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Young, Richard A, Bradner, James E, Winter, Georg E, Gray, Nathanael S

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Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance von Zhou, Wen, Whiteley, Aaron T., de Oliveira Mann, Carina C., Morehouse, Benjamin R., Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Mekalanos, John J., Kranzusch, Philip J.

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Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 von Faust, Tyler B., Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.

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Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome von Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S

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A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader von Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.

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Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations von de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Yang, Priscilla L.

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Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity von Sievers, Quinlan L., Gasser, Jessica A., Cowley, Glenn S., Fischer, Eric S., Ebert, Benjamin L.

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Small molecule modulation of protein polymerization von Fischer, Eric S, Jones, Lyn H

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Chemo-proteomics exploration of HDAC degradability by small molecule degraders von Xiong, Yuan, Donovan, Katherine A., Eleuteri, Nicholas A., Kirmani, Nadia, Yue, Hong, Razov, Anthony, Krupnick, Noah M., Nowak, Radosław P., Fischer, Eric S.

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Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK) von Powell, Chelsea E, Gao, Yang, Tan, Li, Donovan, Katherine A, Nowak, Radosław P, Loehr, Amanda, Bahcall, Magda, Fischer, Eric S, Jänne, Pasi A, George, Rani E, Gray, Nathanael S

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Crystal structure of the human COP9 signalosome von Lingaraju, Gondichatnahalli M., Bunker, Richard D., Cavadini, Simone, Hess, Daniel, Hassiepen, Ulrich, Renatus, Martin, Fischer, Eric S., Thomä, Nicolas H.

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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models von Silva, M Catarina, Ferguson, Fleur M, Cai, Quan, Donovan, Katherine A, Nandi, Ghata, Patnaik, Debasis, Zhang, Tinghu, Huang, Hai-Tsang, Lucente, Diane E, Dickerson, Bradford C, Mitchison, Timothy J, Fischer, Eric S, Gray, Nathanael S, Haggarty, Stephen J

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MEN1 mutations mediate clinical resistance to menin inhibition von Perner, Florian, Stein, Eytan M., Wenge, Daniela V., Singh, Sukrit, Kim, Jeonghyeon, Apazidis, Athina, Rahnamoun, Homa, Anand, Disha, Marinaccio, Christian, Hatton, Charlie, Wen, Yanhe, Stone, Richard M., Schaller, David, Mowla, Shoron, Xiao, Wenbin, Gamlen, Holly A., Stonestrom, Aaron J., Persaud, Sonali, Ener, Elizabeth, Cutler, Jevon A., Doench, John G., McGeehan, Gerard M., Volkamer, Andrea, Chodera, John D., Nowak, Radosław P., Fischer, Eric S., Levine, Ross L., Armstrong, Scott A., Cai, Sheng F.

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INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors von Li, Qing, Jiang, Baishan, Guo, Jiaye, Shao, Hong, Del Priore, Isabella S, Chang, Qing, Kudo, Rei, Li, Zhiqiang, Razavi, Pedram, Liu, Bo, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Donovan, Katherine A, Palafox, Marta, Reis-Filho, Jorge S, de Stanchina, Elisa, Fischer, Eric S, Rosen, Neal, Serra, Violeta, Koff, Andrew, Chodera, John D, Gray, Nathanael S, Chandarlapaty, Sarat

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Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2 von Du, Guangyan, Jiang, Jie, Wu, Qibiao, Henning, Nathaniel J., Donovan, Katherine A., Yue, Hong, Che, Jianwei, Lu, Wenchao, Fischer, Eric S., Bardeesy, Nabeel, Zhang, Tinghu, Gray, Nathanael S.

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Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition von Hunkeler, Moritz, Jin, Cyrus Y., Ma, Michelle W., Monda, Julie K., Overwijn, Daan, Bennett, Eric J., Fischer, Eric S.

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