Reference-based phasing using the Haplotype Reference Consortium panel von Loh, Po-Ru, Danecek, Petr, Palamara, Pier Francesco, Fuchsberger, Christian, A Reshef, Yakir, K Finucane, Hilary, Schoenherr, Sebastian, Forer, Lukas, McCarthy, Shane, Abecasis, Goncalo R, Durbin, Richard, L Price, Alkes

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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights von Gusev, Alexander, Mancuso, Nicholas, Won, Hyejung, Kousi, Maria, Finucane, Hilary K., Reshef, Yakir, Song, Lingyun, Safi, Alexias, McCarroll, Steven, Neale, Benjamin M., Ophoff, Roel A., O’Donovan, Michael C., Crawford, Gregory E., Geschwind, Daniel H., Katsanis, Nicholas, Sullivan, Patrick F., Pasaniuc, Bogdan, Price, Alkes L.

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Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis von Loh, Po-Ru, Bhatia, Gaurav, Gusev, Alexander, Finucane, Hilary K, Bulik-Sullivan, Brendan K, Pollack, Samuela J, de Candia, Teresa R, Lee, Sang Hong, Wray, Naomi R, Kendler, Kenneth S, O'Donovan, Michael C, Neale, Benjamin M, Patterson, Nick, Price, Alkes L

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Functionally informed fine-mapping and polygenic localization of complex trait heritability von Weissbrod, Omer, Hormozdiari, Farhad, Benner, Christian, Cui, Ran, Ulirsch, Jacob, Gazal, Steven, Schoech, Armin P., van de Geijn, Bryce, Reshef, Yakir, Márquez-Luna, Carla, O’Connor, Luke, Pirinen, Matti, Finucane, Hilary K., Price, Alkes L.

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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types von Finucane, Hilary K., Reshef, Yakir A., Anttila, Verneri, Slowikowski, Kamil, Gusev, Alexander, Byrnes, Andrea, Gazal, Steven, Loh, Po-Ru, Lareau, Caleb, Shoresh, Noam, Genovese, Giulio, Saunders, Arpiar, Macosko, Evan, Pollack, Samuela, Perry, John R. B., Buenrostro, Jason D., Bernstein, Bradley E., Raychaudhuri, Soumya, McCarroll, Steven, Neale, Benjamin M., Price, Alkes L.

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Partitioning heritability by functional annotation using genome-wide association summary statistics von Finucane, Hilary K, Bulik-Sullivan, Brendan, Gusev, Alexander, Trynka, Gosia, Reshef, Yakir, Loh, Po-Ru, Anttila, Verneri, Xu, Han, Zang, Chongzhi, Farh, Kyle, Ripke, Stephan, Day, Felix R, Purcell, Shaun, Stahl, Eli, Lindstrom, Sara, Perry, John R B, Okada, Yukinori, Raychaudhuri, Soumya, Daly, Mark J, Patterson, Nick, Neale, Benjamin M, Price, Alkes L

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Detecting Novel Associations in Large Data Sets von Reshef, David N., Reshef, Yakir A., Finucane, Hilary K., Grossman, Sharon R., McVean, Gilean, Turnbaugh, Peter J., Lander, Eric S., Mitzenmacher, Michael, Sabeti, Pardis C.

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Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power von Atkinson, Elizabeth G., Maihofer, Adam X., Kanai, Masahiro, Martin, Alicia R., Karczewski, Konrad J., Santoro, Marcos L., Ulirsch, Jacob C., Kamatani, Yoichiro, Okada, Yukinori, Finucane, Hilary K., Koenen, Karestan C., Nievergelt, Caroline M., Daly, Mark J., Neale, Benjamin M.

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Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits von Hormozdiari, Farhad, Gazal, Steven, van de Geijn, Bryce, Finucane, Hilary K., Ju, Chelsea J.-T., Loh, Po-Ru, Schoech, Armin, Reshef, Yakir, Liu, Xuanyao, O’Connor, Luke, Gusev, Alexander, Eskin, Eleazar, Price, Alkes L.

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Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations von Gazal, Steven, Loh, Po-Ru, Finucane, Hilary K., Ganna, Andrea, Schoech, Armin, Sunyaev, Shamil, Price, Alkes L.

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Interrogation of human hematopoiesis at single-cell and single-variant resolution von Ulirsch, Jacob C., Lareau, Caleb A., Bao, Erik L., Ludwig, Leif S., Guo, Michael H., Benner, Christian, Satpathy, Ansuman T., Kartha, Vinay K., Salem, Rany M., Hirschhorn, Joel N., Finucane, Hilary K., Aryee, Martin J., Buenrostro, Jason D., Sankaran, Vijay G.

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Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection von Schoech, Armin P., Jordan, Daniel M., Loh, Po-Ru, Gazal, Steven, O’Connor, Luke J., Balick, Daniel J., Palamara, Pier F., Finucane, Hilary K., Sunyaev, Shamil R., Price, Alkes L.

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Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues von Liu, Xuanyao, Finucane, Hilary K., Gusev, Alexander, Bhatia, Gaurav, Gazal, Steven, O’Connor, Luke, Bulik-Sullivan, Brendan, Wright, Fred A., Sullivan, Patrick F., Neale, Benjamin M., Price, Alkes L.

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Estimating cross‐population genetic correlations of causal effect sizes von Galinsky, Kevin J., Reshef, Yakir A., Finucane, Hilary K., Loh, Po‐Ru, Zaitlen, Noah, Patterson, Nick J., Brown, Brielin C., Price, Alkes L.

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Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features von Ray, John P., de Boer, Carl G., Fulco, Charles P., Lareau, Caleb A., Kanai, Masahiro, Ulirsch, Jacob C., Tewhey, Ryan, Ludwig, Leif S., Reilly, Steven K., Bergman, Drew T., Engreitz, Jesse M., Issner, Robbyn, Finucane, Hilary K., Lander, Eric S., Regev, Aviv, Hacohen, Nir

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Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease von Yang, Hyun-Sik, Teng, Ling, Kang, Daniel, Menon, Vilas, Ge, Tian, Finucane, Hilary K., Schultz, Aaron P., Properzi, Michael, Klein, Hans-Ulrich, Chibnik, Lori B., Schneider, Julie A., Bennett, David A., Hohman, Timothy J., Mayeux, Richard P., Johnson, Keith A., De Jager, Philip L., Sperling, Reisa A.

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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk von Reshef, Yakir A., Finucane, Hilary K., Kelley, David R., Gusev, Alexander, Kotliar, Dylan, Ulirsch, Jacob C., Hormozdiari, Farhad, Nasser, Joseph, O’Connor, Luke, van de Geijn, Bryce, Loh, Po-Ru, Grossman, Sharon R., Bhatia, Gaurav, Gazal, Steven, Palamara, Pier Francesco, Pinello, Luca, Patterson, Nick, Adams, Ryan P., Price, Alkes L

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Genome-wide functional screen of 3′UTR variants uncovers causal variants for human disease and evolution von Griesemer, Dustin, Xue, James R., Reilly, Steven K., Ulirsch, Jacob C., Kukreja, Kalki, Davis, Joe R., Kanai, Masahiro, Yang, David K., Butts, John C., Guney, Mehmet H., Luban, Jeremy, Montgomery, Stephen B., Finucane, Hilary K., Novina, Carl D., Tewhey, Ryan, Sabeti, Pardis C.

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Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates von Palamara, Pier Francesco, Francioli, Laurent C., Wilton, Peter R., Genovese, Giulio, Gusev, Alexander, Finucane, Hilary K., Sankararaman, Sriram, Sunyaev, Shamil R., de Bakker, Paul I.W., Wakeley, John, Pe’er, Itsik, Price, Alkes L.

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Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores von Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J., Khera, Amit V., Okada, Yukinori, Martin, Alicia R., Finucane, Hilary K., Price, Alkes L.

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