DNA targeting specificity of RNA-guided Cas9 nucleases von Hsu, Patrick D, Scott, David A, Weinstein, Joshua A, Ran, F Ann, Konermann, Silvana, Agarwala, Vineeta, Li, Yinqing, Fine, Eli J, Wu, Xuebing, Shalem, Ophir, Cradick, Thomas J, Marraffini, Luciano A, Bao, Gang, Zhang, Feng

Volltext

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites von Cradick, Thomas J, Qiu, Peng, Lee, Ciaran M, Fine, Eli J, Bao, Gang

Volltext

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage von Fine, Eli J, Cradick, Thomas J, Zhao, Charles L, Lin, Yanni, Bao, Gang

Volltext

Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing von Hendel, Ayal, Kildebeck, Eric J, Fine, Eli J, Clark, Joseph, Punjya, Niraj, Sebastiano, Vittorio, Bao, Gang, Porteus, Matthew H

Volltext

Preclinical Development of a Hematopoietic Stem and Progenitor Cell Bioengineered Factor VIII Lentiviral Vector Gene Therapy for Hemophilia A von Doering, Christopher B, Denning, Gabriela, Shields, Jordan E, Fine, Eli J, Parker, Ernest T, Srivastava, Alok, Lollar, Pete, Spencer, H Trent

Volltext

CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep von Vilarino, Marcela, Rashid, Sheikh Tamir, Suchy, Fabian Patrik, McNabb, Bret Roberts, van der Meulen, Talitha, Fine, Eli J., Ahsan, Syed Daniyal, Mursaliyev, Nurlybek, Sebastiano, Vittorio, Diab, Santiago Sain, Huising, Mark O., Nakauchi, Hiromitsu, Ross, Pablo J.

Volltext

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity von Cradick, Thomas J, Fine, Eli J, Antico, Christopher J, Bao, Gang

Volltext

SAPTA: a new design tool for improving TALE nuclease activity von Lin, Yanni, Fine, Eli J, Zheng, Zhilan, Antico, Christopher J, Voit, Richard A, Porteus, Matthew H, Cradick, Thomas J, Bao, Gang

Volltext

Trans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human cells using compact expression cassettes von Fine, Eli J., Appleton, Caleb M., White, Douglas E., Brown, Matthew T., Deshmukh, Harshavardhan, Kemp, Melissa L., Bao, Gang

Volltext

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing von Lee, Ciaran M, Cradick, Thomas J, Fine, Eli J, Bao, Gang

Volltext

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity von Mussolino, Claudio, Alzubi, Jamal, Fine, Eli J, Morbitzer, Robert, Cradick, Thomas J, Lahaye, Thomas, Bao, Gang, Cathomen, Toni

Volltext

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs von Suzuki, Shingo, Sargent, R Geoffrey, Illek, Beate, Fischer, Horst, Esmaeili-Shandiz, Alaleh, Yezzi, Michael J, Lee, Albert, Yang, Yanu, Kim, Soya, Renz, Peter, Qi, Zhongxia, Yu, Jingwei, Muench, Marcus O, Beyer, Ashley I, Guimarães, Alessander O, Ye, Lin, Chang, Judy, Fine, Eli J, Cradick, Thomas J, Bao, Gang, Rahdar, Meghdad, Porteus, Matthew H, Shuto, Tsuyoshi, Kai, Hirofumi, Kan, Yuet W, Gruenert, Dieter C

Volltext

Quantifying on- and off-target genome editing von Hendel, Ayal, Fine, Eli J, Bao, Gang, Porteus, Matthew H

Volltext

Nanomedicine: Tiny Particles and Machines Give Huge Gains von Tong, Sheng, Fine, Eli J., Lin, Yanni, Cradick, Thomas J., Bao, Gang

Volltext

Author Correction: CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep von Vilarino, Marcela, Rashid, Sheikh Tamir, Suchy, Fabian Patrik, McNabb, Bret Roberts, van der Meulen, Talitha, Fine, Eli J., Ahsan, Syed Daniyal, Mursaliyev, Nurlybek, Sebastiano, Vittorio, Diab, Santiago Sain, Huising, Mark O., Nakauchi, Hiromitsu, Ross, Pablo J.

Volltext

Clinical trials-in-a-dish: Different inter-individual drug responses for calcium handling and electrophysiology in a cohort of hiPSC-derived cardiomyocytes von Fermini, Bernard, Sullivan, Denise D., Chal, Jerome, Fine, Eli J., Coyne, Shawn T., King, Alexia, Johnson, Jessica, Hernandez, Alexander Ulan, Obata, Chinye F., Coyne, Kevin P.

Volltext

Identification of Off-Target Cleavage Sites of Zinc Finger Nucleases and TAL Effector Nucleases Using Predictive Models von Fine, Eli J., Cradick, Thomas J., Bao, Gang

Volltext

CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep (vol 7, 17472, 2017) von Vilarino, Marcela, Rashid, Sheikh Tamir, Suchy, Fabian Patrik, McNabb, Bret Roberts, van der Meulen, Talitha, Fine, Eli J., Ahsan, Syed Daniyal, Mursaliyev, Nurlybek, Sebastiano, Vittorio, Diab, Santiago Sain, Huising, Mark O., Nakauchi, Hiromitsu, Ross, Pablo J.

Volltext

682. Applied In Silico Engineering of Factor VIII-AAV Transgene Cassettes von Brown, Harrison C., Fine, Eli J., Parker, Ernest T., Trent Spencer, H., Doering, Christopher B.

Volltext

Leveraging genetic diversity in vitro: Evolution or revolution in cardiac safety assessment? von Fine, Eli J., Sullivan, Denise D., Nguyen, Anh H., Chal, Jerome, Hamilton, Jonathon B., Coyne, Kevin P., Coyne, Shawn T., Mobley, Sheldon L., Poe-Yamagata, Emma M., Dobric, Maja, Fermini, Bernard

Volltext