Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort von Reddel, Helen K., Vestbo, Jorgen, Agusti, Alvar, Anderson, Gary P., Bansal, Aruna T., Beasley, Richard, Bel, Elisabeth H., Janson, Christer, Make, Barry, Pavord, Ian D., Price, David, Rapsomaniki, Eleni, Karlsson, Niklas, Finch, Donna K., Nuevo, Javier, De Giorgio-Miller, Alex, Alacqua, Marianna, Hughes, Rod, Mullerova, Hana, de Verdier, Maria Gerhardsson

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Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures von Galson, Jacob D., Schaetzle, Sebastian, Bashford-Rogers, Rachael J. M., Raybould, Matthew I. J., Kovaltsuk, Aleksandr, Kilpatrick, Gavin J., Minter, Ralph, Finch, Donna K., Dias, Jorge, James, Louisa K., Thomas, Gavin, Lee, Wing-Yiu Jason, Betley, Jason, Cavlan, Olivia, Leech, Alex, Deane, Charlotte M., Seoane, Joan, Caldas, Carlos, Pennington, Daniel J., Pfeffer, Paul, Osbourn, Jane

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A randomised, placebo-controlled trial of anti-interleukin-1 receptor 1 monoclonal antibody MEDI8968 in chronic obstructive pulmonary disease von Calverley, Peter M A, Sethi, Sanjay, Dawson, Michelle, Ward, Christine K, Finch, Donna K, Penney, Mark, Newbold, Paul, van der Merwe, René

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De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8 von Roy, Anindya, Shi, Lei, Chang, Ashley, Dong, Xianchi, Fernandez, Andres, Kraft, John C., Li, Jing, Le, Viet Q., Winegar, Rebecca Viazzo, Cherf, Gerald Maxwell, Slocum, Dean, Poulson, P. Daniel, Casper, Garrett E., Vallecillo-Zúniga, Mary L., Valdoz, Jonard Corpuz, Miranda, Marcos C., Bai, Hua, Kipnis, Yakov, Olshefsky, Audrey, Priya, Tanu, Carter, Lauren, Ravichandran, Rashmi, Chow, Cameron M., Johnson, Max R., Cheng, Suna, Smith, McKaela, Overed-Sayer, Catherine, Finch, Donna K., Lowe, David, Bera, Asim K., Matute-Bello, Gustavo, Birkland, Timothy P., DiMaio, Frank, Raghu, Ganesh, Cochran, Jennifer R., Stewart, Lance J., Campbell, Melody G., Van Ry, Pam M., Springer, Timothy, Baker, David

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The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells von Piper, Siân C, Ferguson, John, Kay, Linda, Parker, Lisa C, Sabroe, Ian, Sleeman, Matthew A, Briend, Emmanuel, Finch, Donna K

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Effects of CXCL13 inhibition on lymphoid follicles in models of autoimmune disease von Finch, Donna K., Ettinger, Rachel, Karnell, Jodi L., Herbst, Ronald, Sleeman, Matthew A.

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Haplosaurus computes protein haplotypes for use in precision drug design von Spooner, William, McLaren, William, Slidel, Timothy, Finch, Donna K., Butler, Robin, Campbell, Jamie, Eghobamien, Laura, Rider, David, Kiefer, Christine Mione, Robinson, Matthew J., Hardman, Colin, Cunningham, Fiona, Vaughan, Tristan, Flicek, Paul, Huntington, Catherine Chaillan

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FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis von Leslie, Jack, Millar, Ben J. M., Pons, Alicia del Carpio, Burgoyne, Rachel A., Frost, Joseph D., Barksby, Ben S., Luli, Saimir, Scott, Jon, Simpson, A. John, Gauldie, Jack, Murray, Lynne A., Finch, Donna K., Carruthers, Alan M., Ferguson, John, Sleeman, Matthew A., Rider, David, Howarth, Rachel, Fox, Christopher, Oakley, Fiona, Fisher, Andrew J., Mann, Derek A., Borthwick, Lee A.

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Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease von Wiegman, Coen H., PhD, Michaeloudes, Charalambos, PhD, Haji, Gulammehdi, MD, Narang, Priyanka, PhD, Clarke, Colin J., MSc, Russell, Kirsty E., PhD, Bao, Wuping, MD, Pavlidis, Stelios, PhD, Barnes, Peter J., MD, Kanerva, Justin, MSc, Bittner, Anton, PhD, Rao, Navin, PhD, Murphy, Michael P., PhD, Kirkham, Paul A., PhD, Chung, Kian Fan, MD, Adcock, Ian M., PhD

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Distal lung epithelial progenitor cell function declines with age von Watson, Julie K., Sanders, Philip, Dunmore, Rebecca, Rosignoli, Guglielmo, Julé, Yvon, Rawlins, Emma L., Mustelin, Tomas, May, Richard, Clarke, Deborah, Finch, Donna K.

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Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα von Finch, Donna K, Stolberg, Valerie R, Ferguson, John, Alikaj, Henrih, Kady, Mohamed R, Richmond, Bradley W, Polosukhin, Vasiliy V, Blackwell, Timothy S, McCloskey, Lisa, Curtis, Jeffrey L, Freeman, Christine M

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Metabolic re-patterning in COPD airway smooth muscle cells von Michaeloudes, Charalambos, Kuo, Chih-Hsi, Haji, Gulam, Finch, Donna K, Halayko, Andrew J, Kirkham, Paul, Chung, Kian Fan, Adcock, Ian M

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Predictability of B cell clonal persistence and immunosurveillance in breast cancer von Sammut, Stephen-John, Galson, Jacob D., Minter, Ralph, Sun, Bo, Chin, Suet-Feung, De Mattos-Arruda, Leticia, Finch, Donna K., Schätzle, Sebastian, Dias, Jorge, Rueda, Oscar M., Seoane, Joan, Osbourn, Jane, Caldas, Carlos, Bashford-Rogers, Rachael J. M.

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Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity von Rudnicka, Dominika, Oszmiana, Anna, Finch, Donna K., Strickland, Ian, Schofield, Darren J., Lowe, David C., Sleeman, Matthew A., Davis, Daniel M.

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Development of therapeutic antibodies to G protein-coupled receptors and ion channels: Opportunities, challenges and their therapeutic potential in respiratory diseases von Douthwaite, Julie A, Finch, Donna K, Mustelin, Tomas, Wilkinson, Trevor C I

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Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation von Queiroz, Rayner M L, Piper, Siân C, Rees, Johanna S, Strickson, Sam, Briend, Emmanuel, Low, Choon Pei, Ferguson, G John, Lilley, Kathryn S, Jackson, Antony P, Finch, Donna K

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Neutrophil GM‐CSF receptor dynamics in acute lung injury von Alessandris, Silvia, Ferguson, G. John, Dodd, Alison J., Juss, Jatinder K., Devaprasad, Abhinandan, Piper, Siân, Wyatt, Owen, Killick, Helen, Corkill, Dominic J., Cohen, E. Suzanne, Pandit, Aridaman, Radstake, Timothy R.D.J., Simmonds, Rosalind, Condliffe, Alison M., Sleeman, Matthew A., Cowburn, Andrew S., Finch, Donna K., Chilvers, Edwin R.

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IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD von Briend, Emmanuel, Ferguson, G John, Mori, Michiko, Damera, Gautam, Stephenson, Katherine, Karp, Natasha A, Sethi, Sanjay, Ward, Christine K, Sleeman, Matthew A, Erjefält, Jonas S, Finch, Donna K

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Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1 von Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J

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Whole-Molecule Antibody Engineering: Generation of a High-Affinity Anti-IL-6 Antibody with Extended Pharmacokinetics von Finch, Donna K., Sleeman, Matthew A., Moisan, Jacques, Ferraro, Franco, Botterell, Sara, Campbell, Jamie, Cochrane, Duncan, Cruwys, Simon, England, Elizabeth, Lane, Steven, Rendall, Elizabeth, Sinha, Monisha, Walker, Craig, Rees, Gareth, Bowen, Michael A., Schneider, Amy, Liang, Meina, Faggioni, Raffaella, Fung, Michael, Mallinder, Philip R., Wilkinson, Trevor, Kolbeck, Roland, Vaughan, Tristan, Lowe, David C.

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