The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease von Figley, Matthew D, DiAntonio, Aaron

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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration von Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron, Ve, Thomas

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The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems von DiAntonio, Aaron, Milbrandt, Jeffrey, Figley, Matthew D. D.

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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models von Armakola, Maria, Higgins, Matthew J, Figley, Matthew D, Barmada, Sami J, Scarborough, Emily A, Diaz, Zamia, Fang, Xiaodong, Shorter, James, Krogan, Nevan J, Finkbeiner, Steven, Farese, Robert V, Gitler, Aaron D

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Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss von Wu, Tong, Zhu, Jian, Strickland, Amy, Ko, Kwang Woo, Sasaki, Yo, Dingwall, Caitlin B., Yamada, Yurie, Figley, Matthew D., Mao, Xianrong, Neiner, Alicia, Bloom, A. Joseph, DiAntonio, Aaron, Milbrandt, Jeffrey

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Evaluating noncoding nucleotide repeat expansions in amyotrophic lateral sclerosis von Figley, Matthew D, Thomas, Anna, Gitler, Aaron D

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Neurodegeneration: A Leg Up on TDP-43 von Figley, Matthew D., Gitler, Aaron D.

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cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons von Sasaki, Yo, Engber, Thomas M., Hughes, Robert O., Figley, Matthew D., Wu, Tong, Bosanac, Todd, Devraj, Rajesh, Milbrandt, Jeffrey, Krauss, Raul, DiAntonio, Aaron

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Multiple domain interfaces mediate SARM1 autoinhibition von Shen, Chen, Vohra, Mihir, Zhang, Pengfei, Mao, Xianrong, Figley, Matthew D., Zhu, Jian, Sasaki, Yo, Wu, Hao, DiAntonio, Aaron, Milbrandt, Jeffrey

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Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics von Figley, Matthew D, Bieri, Gregor, Kolaitis, Regina-Maria, Taylor, J Paul, Gitler, Aaron D

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Yeast genetic screen reveals novel therapeutic strategy for ALS von Figley, Matthew D., Gitler, Aaron D.

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Evaluating non-coding nucleotide repeat expansions in amyotrophic lateral sclerosis von Figley, Matthew D., Thomas, Anna, Gitler, Aaron D.

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