Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing von Valentine, Charles C., Young, Robert R., Fielden, Mark R., Kulkarni, Rohan, Williams, Lindsey N., Li, Tan, Minocherhomji, Sheroy, Salk, Jesse J.

Volltext

A Gene Expression Biomarker Provides Early Prediction and Mechanistic Assessment of Hepatic Tumor Induction by Nongenotoxic Chemicals von Fielden, Mark R., Brennan, Richard, Gollub, Jeremy

Volltext

Induction of Cyp1a1 Is a Nonspecific Biomarker of Aryl Hydrocarbon Receptor Activation: Results of Large Scale Screening of Pharmaceuticals and Toxicants in Vivo and in Vitro von Hu, Wenyue, Sorrentino, Claudio, Denison, Michael S, Kolaja, Kyle, Fielden, Mark R

Volltext

Validation of putative genomic biomarkers of nephrotoxicity in rats von Wang, Er-Jia, Snyder, Ronald D, Fielden, Mark R, Smith, Roger J, Gu, Yi-Zhong

Volltext

Development and Evaluation of a Genomic Signature for the Prediction and Mechanistic Assessment of Nongenotoxic Hepatocarcinogens in the Rat von Fielden, Mark R., Adai, Alex, Dunn, Robert T., Olaharski, Andrew, Searfoss, George, Sina, Joe, Aubrecht, Jiri, Boitier, Eric, Nioi, Paul, Auerbach, Scott, Jacobson-Kram, David, Raghavan, Nandini, Yang, Yi, Kincaid, Andrew, Sherlock, Jon, Chen, Shen-Jue, Car, Bruce

Volltext

The liver pharmacological and xenobiotic gene response repertoire von Idury, Radha, Roter, Alan H, Brennan, Richard J, Fielden, Mark R, Jarnagin, Kurt, Ferng, Joe, Pearson, Cecelia I, P Eynon, Barrett, Nair, Ramesh, Natsoulis, Georges, Lee, May D, Gollub, Jeremy

Volltext

Biomarkers of genome instability in normal mammalian genomes following drug‐induced replication stress von Minocherhomji, Sheroy, Liu, Yang, He, Yudong D., Fielden, Mark R.

Volltext

Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism von Fielden, Mark R., Dean, Charles, Black, Kurt, Sawant, Satin G., Subramanian, Raju, Tomlinson, James E., Walter, Sarah, Zimmermann, Cameron, Griggs, Mark W., McKeon, Marie E., Lewis, Elise M., Beevers, Carol, Pyrah, Ian

Volltext

Modernizing Human Cancer Risk Assessment of Therapeutics von Fielden, Mark R., Ward, Lucas D., Minocherhomji, Sheroy, Nioi, Paul, Lebrec, Herve, Jacobson-Kram, David

Volltext

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat von Fielden, Mark R., Werner, Jonathan, Jamison, Jeff A., Coppi, Aldo, Hickman, Dean, Dunn, Robert T., Trueblood, Esther, Zhou, Lei, Afshari, Cynthia A., Lightfoot-Dunn, Ruth

Volltext

Evaluation of genotoxicity testing of FDA approved large molecule therapeutics von Sawant, Satin G., Fielden, Mark R., Black, Kurt A.

Volltext

Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans von Fielden, Mark R., Hassani, Mary, Uppal, Hirdesh, Day-Lollini, Patricia, Button, Donald, Martin, Renee S., Garrido, Rosario, Liu, Xingrong, Kolaja, Kyle L.

Volltext

Challenges and Limitations of Gene Expression Profiling in Mechanistic and Predictive Toxicology von Fielden, Mark R., Zacharewski, Tim R.

Volltext

Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action von Ganter, Brigitte, Tugendreich, Stuart, Pearson, Cecelia I., Ayanoglu, Eser, Baumhueter, Susanne, Bostian, Keith A., Brady, Lindsay, Browne, Leslie J., Calvin, John T., Day, Gwo-Jen, Breckenridge, Naiomi, Dunlea, Shane, Eynon, Barrett P., Furness, L. Mike, Ferng, Joe, Fielden, Mark R., Fujimoto, Susan Y., Gong, Li, Hu, Christopher, Idury, Radha, Judo, Michael S.B., Kolaja, Kyle L., Lee, May D., McSorley, Christopher, Minor, James M., Nair, Ramesh V., Natsoulis, Georges, Nguyen, Peter, Nicholson, Simone M., Pham, Hang, Roter, Alan H., Sun, Dongxu, Tan, Siqi, Thode, Silke, Tolley, Alexander M., Vladimirova, Antoaneta, Yang, Jian, Zhou, Zhiming, Jarnagin, Kurt

Volltext

The role of early in vivo toxicity testing in drug discovery toxicology von Fielden, Mark R, Kolaja, Kyle L

Volltext

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D von Low, Jonathan D, Bartberger, Michael D, Chen, Kui, Cheng, Yuan, Fielden, Mark R, Gore, Vijay, Hickman, Dean, Liu, Qingyian, Allen Sickmier, E, Vargas, Hugo M, Werner, Jonathan, White, Ryan D, Whittington, Douglas A, Wood, Stephen, Minatti, Ana E

Volltext

Characterization of Xenobiotic-Induced Hepatocellular Enzyme Induction in Rats: Anticipated Thyroid Effects and Unique Pituitary Gland Findings von Zabka, Tanja S., Fielden, Mark R., Garrido, Rosario, Tao, Jianhua, Fretland, Adrian J., Fretland, Jennifer L., Albassam, Mudher A., Singer, Thomas, Kolaja, Kyle L.

Volltext

A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity von Fielden, Mark R., Eynon, Barrett P., Natsoulis, Georges, Jarnagin, Kurt, Banas, Deborah, Kolaja, Kyle L.

Volltext

Authors’ Response to Letter to the Editor on “Image Cytometry Protocols” von Garrido, Rosario, Zabka, Tanja S., Tao, Jianhua, Fielden, Mark R., Fretland, Adrian J., Albassam, Mudher

Volltext

Preclinical drug safety analysis by chemogenomic profiling in the liver von Fielden, Mark R, Pearson, Cecelia, Brennan, Richard, Kolaja, Kyle L

Volltext