Cellular and clinical pharmacokinetic/pharmacodynamic basis for lack of efficacy of 21-day continuous topotecan in patients with untreated advanced adenocarcinoma of the pancreas von Mans, D R, Di Leone, L, Ferrary Caldas, A P, Maino, M, Almeida, L, Cancela, A I, Grivicich, I, Brondani da Rocha, A, Schwartsmann, G

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