Janus kinase inhibitor ruxolitinib in combination with nilotinib and prednisone in patients with myelofibrosis (RuNiC study): A phase Ib, multicenter study von Ayala, Rosa, Fernández, Rafael Alonso, García‐Gutiérrez, Valentín, Alvarez‐Larrán, Alberto, Osorio, Santiago, Sánchez‐Pina, Jose M., Carreño‐Tarragona, Gonzalo, Álvarez, Noemi, Gómez‐Casares, María Teresa, Duran, Antonia, Gorrochategi, Julian, Hernández‐Boluda, Juan Carlos, Martínez‐López, Joaquín

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Cereblon enhancer methylation and IMiD resistance in multiple myeloma von Haertle, Larissa, Barrio, Santiago, Munawar, Umair, Han, Seungbin, Zhou, Xiang, Vogt, Cornelia, Fernández, Rafael Alonso, Bittrich, Max, Ruiz-Heredia, Yanira, Da Viá, Matteo, Zovko, Josip, Garitano-Trojaola, Andoni, Bolli, Niccolò, Ruckdeschel, Anna, Stühmer, Thorsten, Chatterjee, Manik, Kull, Miriam, Krönke, Jan, Agirre, Xabier, Martin-Subero, Jose I., Raab, Peter, Einsele, Hermann, Rasche, Leo, Martinez-Lopez, Joaquin, Haaf, Thomas, Kortüm, K. Martin

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Immunoparesis recovery in newly diagnosed transplant ineligible multiple myeloma patients, an independent prognostic factor that complements minimal residual disease von Lakhwani, Sunil, Mateos, María Victoria, Martínez-López, Joaquín, Paiva, Bruno, Rosiñol Dachs, Laura, Martínez, Rafael, Oriol, Albert, Bargay, Joan, González-Montes, Yolanda, Gironella, Mercedes, Encinas, Cristina, Martín, Jesús, Jarque, Isidro, Granell, Miquel, Abella, Eugenia, García-Mateo, Aránzazu, Hernández-Rivas, José Ángel, Ramila, Elena, Krsnik, Isabel, Casado Montero, Luis Felipe, De Arriba, Felipe, Palomera, Luis, Sampol, Antonia, Moraleda, José María, Casanova, María, Delgado, Pilar, Lafuente, Ana, Amutio, Elena, López-Martínez, Aurelio, Altés, Albert, Ruíz, M Ángeles, Alegre, Adrián, Lopez-Anglada, Lucia, De La Cruz, Javier, Alonso Fernández, Rafael, Bladé Creixenti, Joan, Lahuerta, Juan-José, San-Miguel, Jesús, Hernández, Miguel-Teodoro

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P840: ASSESSMENT OF CONVENTIONAL TRANSLOCATIONS AND IG REARRANGEMENTS IN THE DIAGNOSIS OF MULTIPLE MYELOMA PATIENTS USING A TARGETED CAPTURE‐HYBRIDIZATION RNA SEQUENCING PANEL von Buenache Cuenda, Natalia, Sánchez, Ricardo, Giménez Sánchez, Alicia, Carneros Blanco, Laura, Alonso Fernández, Rafael, Pina, José María Sánchez, Rapado Martínez, Inmaculada, Ayala Diaz, Rosa, Martinez‐Lopez, Joaquín, Rosa, Juan Manuel Rosa

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Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma von Haertle, Larissa, Barrio, Santiago, Munawar, Umair, Han, Seungbin, Zhou, Xiang, Simicek, Michal, Vogt, Cornelia, Truger, Marietta, Fernandez, Rafael Alonso, Steinhardt, Maximilian, Weingart, Julia, Snaurova, Renata, Nerreter, Silvia, Teufel, Eva, Garitano-Trojaola, Andoni, Da Viá, Matteo, Ruiz-Heredia, Yanira, Rosenwald, Andreas, Bolli, Niccolò, Hajek, Roman, Raab, Peter, Raab, Marc S, Weinhold, Niels, Haferlach, Claudia, Haaf, Thomas, Martinez-Lopez, Joaquin, Einsele, Hermann, Rasche, Leo, Kortüm, K Martin

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Real-life experience with first-line treatment with daratumumab, bortezomib, melphalan, and prednisone in patients with newly diagnosed multiple myeloma ineligible for autologous s... von Domingo-González, Amalia, Alonso Fernández, Rafael, Jiménez, Ana, De Soto Álvarez, Teresa, Lerma-Verdejo, Ana, Pradillo, Virginia, Benzo Callejo, Gonzalo, Sánchez-Pina, Jose, Landete, Elena, Velasco-Valdazo, Alberto, Menéndez-Cuevas, Marina, López Riñón, Mónica María, Ramírez-López, Andrés, Blanchard, María-Jesús, Askari, Elham

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S256: HLA‐E/NKG2A CHECKPOINT DRIVES MULTIPLE MYELOMA RESISTANCE TO CAR‐NK THERAPY von Encinas, Jessica, García‐Ortiz, Almudena, Maroto‐Martín, Elena, Castellano, Eva, Oliva, Raquel, Alonso Fernández, Rafael, Teresa Cedena Romero, Maria, Leivas, Alejandra, Martín‐Antonio, Beatriz, Suñe, Guillermo, Lee, Dean A., Powell, Daniel J., Río, Paula, Martinez‐Lopez, Joaquín, Valeri, Antonio

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The Role of Hepatitis C Virus in the Development of Multiple Myeloma: A Case Study von Rodríguez García, Alba, Linares, María, Mennesson, Nicolas, Sanchez-Vega, Beatriz, Sanchez, Ricardo, Fernandez, Rafael Alonso, Bigot-Corbel, Edith, Hermouet, Sylvie, Martinez Lopez, Joaquin

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Absence of Contribution to a Differential Outcome of the Stringent Complete Response IMWG Category Respect to the Conventional CR in Multiple Myeloma. a Validation Analysis Based o... von Jiménez Ubieto, Ana, Martinez Lopez, Joaquin, Rosinol, Laura, Paiva, Bruno, Cedena, María Teresa, Puig, Noemi, Calasanz, Maria Jose, Gonzalez Medina, José, Martin-Ramos, Maria Luisa, Fernandez, Rafael Alonso, Oriol, Albert, Blanchard, Jesús, Ocio, Enrique M., De La Rubia, Javier, Rios, Rafael, Martín, Jesús, Hernández, Miguel-Teodoro, Krsnik, Isabel, Moraleda, Jose Maria, Palomera, Luis, Bargay, Joan, Mateos, Maria-Victoria, San-Miguel, Jesús F, Bladé, Joan, Lahuerta, Juan-José

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Immunofixation (IF) in Urine Is Really Necessary to Define Complete Remission in Multiple Myeloma (MM)? a Subanalysis from the Pethema/GEM2012MENOS65 Phase III Clinical Trial von Jiménez Ubieto, Ana, Paiva, Bruno, Martínez-López, Joaquin, Rosinol, Laura, Cedena Romero, Maria Teresa, Calasanz, Maria Jose, Puig, Noemi, Garcia-Sanz, Ramon, Gutierrez, Norma C., Martin-Ramos, Maria Luisa, Oriol, Albert, Gonzalez Medina, José, Fernandez, Rafael Alonso, Blanchard, Jesús, Rios, Rafael, Martín, Jesús, Martinez Martinez, Rafael, Sarra, Josep, Hernández, Miguel-Teodoro, De La Rubia, Javier, Krsnik, Isabel, Moraleda, Jose Maria, Palomera, Luis, Mateos, Maria-Victoria, San-Miguel, Jesús F, Bladé, Joan, Lahuerta, Juan-José

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Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15 von Fernandez, Rafael Alonso, Mayoral, Jessica Encinas, Pierre-Louis, Laetitia, Yao, Yao, Xu, Yan, Mu, Shidai, Martinez-Lopez, Joaquin, Primo, Daniel, Miyazaki, Takahiro, Prabhala, Rao, Anderson, Kenneth C., Overwijk, Willem W., Munshi, Nikhil C., Fulciniti, Mariateresa

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Correlation Between Clinical Features, CRLF2 Expression and Copy Number Alterations In Acute Lymphoblastic Leukemia von Ponce Jarquin, Juan Carlos, Ayala, Rosa M., Dueñas Perez, Ana Belen, Rueda, Daniel, Martin Ramos, María Luisa, Vivanco, José Luis, Sánchez, Pilar Martinez, Alonso Fernandez, Rafael Alberto, Rodriguez, Florinda Gilsanz, Martinez -Lopez, Joaquin

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Real-Life Experience of the Combination of Daratumumab, Bortezomib, Melphalan, and Prednisone (DVMP) in Patients with Newly Diagnosed Multiple Myeloma Ineligible for Autologous Ste... von Domingo-González, Amalia, Alonso Fernández, Rafael, Jiménez, Ana, De Soto Alvarez, Teresa, Lerma, Ana, Pradillo Fernandez, Virginia, Benzo Callejo, Gonzalo, Sanchez-Pina, Jose, Landete, Elena, Velasco, Alberto, Menéndez Cuevas, Marina, López Riñón, Mónica María, Ramírez López, Andrés, Lopez Garcia, Alberto, Blanchard, María-Jesús, Askari, Elham

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Large Scale Analysis of Autologous Stem Cell Transplantation for Multiple Myeloma Patients Older Than 65 Years von Sáez Marín, Adolfo Jesús, Hernández-Ibarburu, Gema, Alonso Fernández, Rafael, Sanchez Pina, Jose Maria, Lázaro Del Campo, Paula, Jimenez Ubieto, Ana, Cuellar, Clara, Tamayo Soto, Andrea, Mas Babio, Reyes, Medina, Lucia, Calbacho, Maria, Ayala, Rosa, Martinez Lopez, Joaquin

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Triple Combination of Ruxolutinib, Nilotinib and Prednisone Is Safe and Shows Promising Activity for the Treatment of Myelofibrosis Patients, Results of a Phase Ib Clinical Trial (... von Ayala, Rosa, Alonso Fernández, Rafael, Garcia Gutierrez, Valentín, Alvarez-Larran, Alberto, Osorio, Santiago, Sanchez, Jose M., Carreño Gomez-Tarragona, Gonzalo, Gómez-Casares, María Teresa, Duran, Antonia, Martínez-López, Joaquín

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Making Clinical Decisions to Change Therapy Using Measurable Residual Disease Improves the Outcome in Multiple Myeloma von Martinez Lopez, Joaquin, Alonso Fernández, Rafael, Wong, Sandy W., Rios, Rafael, Shah, Nina, Cedena Romero, Maria Teresa, Ruiz-Heredia, Yanira, Sanchez, Jose M., Barrio Garcia, Santiago, Martin, Thomas, Wolf, Jeffrey L.

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Sustained Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Discriminates Patients with Sustained Negative Minimal Residual Disease von Lakhwani, Sunil, Rosiñol, Laura, Puig, Noemi, Pico Picos, Miguel Angel, Medina-González, Laura, Martinez Lopez, Joaquin, Paiva, Bruno, Cedena Romero, Maria Teresa, Oriol, Albert, Ríos, Rafael, Blanchard, María Jesús, Jarque, Isidro, Bargay, Joan, Moraleda, Jose Maria, Carrillo-Cruz, Estrella, Sureda Balari, Anna Maria, Krsnik, Isabel, Gonzalez Garcia, Esther, Casado Montero, Luis Felipe, Marti Tutusaus, Josep Maria, Encinas Rodriguez, Cristina, De Arriba, Felipe, Palomera, Luis, Sampol Mayol, Antonia, González-Montes, Yolanda, Motlló, Cristina, De la Cruz, Javier, Alonso Fernández, Rafael, Mateos, Maria-Victoria, Blade Creixenti, Joan, Lahuerta Palacios, Juan Jose, San Miguel, Jesus, Hernández Garcia, Miguel Teodoro

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Compassionate Use of Belantamab Mafodotin for Treatment of Patients with Relapsed/Refractory Multiple Myeloma Heavily Treated. Spanish Experience von Alegre, Adrian, Benzo Callejo, Gonzalo, Alonso Fernández, Rafael, Martínez-López, Joaquin, Jimenez-Ubieto, Ana, Cuellar, Clara, Askari, Elham, Prieto, Elena, Alaez, Concha, Aguado, Beatriz, Velasco, Alberto, Krsnik, Isabel, Llorente, Laura, Muñoz-Linares, Cristina, Morales, Ana, Mesa, Eugenio Gimenez, Iglesias, Rebeca, Martínez-Chamorro, Carmen, Alonso, Arancha, Jiménez-Montes, Carmen, Blanchard, María Jesús

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The Role of Antiviral Treatment in Hepatitis C Virus (HCV)-Driven Monoclonal Gammopathies von Rodríguez García, Alba, Linares, María, Mennesson, Nicolas, Pérez-Revilla, Alfredo, Sanchez, Ricardo, Leivas, Alejandra, Fernández, Rafael Alonso, Bigot-Corbel, Edith, Hermouet, Sylvie, Martinez-Lopez, Joaquin

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Restoring Innate and Adaptive Immune Repertoire in Multiple Myeloma for Therapeutic Application von Fernández, Rafael Alonso, Pierre-Louis, Laetitia, Prabhala, Rao, Xu, Yan, Martinez-Lopez, Joaquin, Miyazaki, Takahiro, Samur, Mehmet Kemal, Madakamutil, Loui, Fulciniti, Mariateresa, Munshi, Nikhil C.

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