Halogen–Aromatic π Interactions Modulate Inhibitor Residence Times von Heroven, Christina, Georgi, Victoria, Ganotra, Gaurav K., Brennan, Paul, Wolfreys, Finn, Wade, Rebecca C., Fernández‐Montalván, Amaury E., Chaikuad, Apirat, Knapp, Stefan

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Characterization of 12 GnRH peptide agonists – a kinetic perspective von Nederpelt, Indira, Georgi, Victoria, Schiele, Felix, Nowak‐Reppel, Katrin, Fernández‐Montalván, Amaury E., IJzerman, Adriaan P., Heitman, Laura H.

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Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target von Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, Ter Laak, Antonius, Fernández-Montalván, Amaury E, Eberspaecher, Uwe, Werbeck, Nicolas D, Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L, Stresemann, Carlo

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Considerations for improved performance of competition association assays analysed with the Motulsky–Mahan's “kinetics of competitive binding” model von Georgi, Victoria, Dubrovskiy, Alexey, Steigele, Stephan, Fernández‐Montalván, Amaury E.

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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase von Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus

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Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone... von Panknin, Olaf, Wagenfeld, Andrea, Bone, Wilhelm, Bender, Eckhard, Nowak-Reppel, Katrin, Fernández-Montalván, Amaury E, Nubbemeyer, Reinhard, Bäurle, Stefan, Ring, Sven, Schmees, Norbert, Prien, Olaf, Schäfer, Martina, Friedrich, Christian, Zollner, Thomas M, Steinmeyer, Andreas, Mueller, Thomas, Langer, Gernot

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Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains von Bouché, Léa, Christ, Clara D, Siegel, Stephan, Fernández-Montalván, Amaury E, Holton, Simon J, Fedorov, Oleg, ter Laak, Antonius, Sugawara, Tatsuo, Stöckigt, Detlef, Tallant, Cynthia, Bennett, James, Monteiro, Octovia, Díaz-Sáez, Laura, Siejka, Paulina, Meier, Julia, Pütter, Vera, Weiske, Jörg, Müller, Susanne, Huber, Kilian V. M, Hartung, Ingo V, Haendler, Bernard

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Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action von Fernández-Montalván, Amaury E, Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J, Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A, Clark, Matthew A, Dumelin, Christoph E, Sigel, Eric A, Soutter, Holly H, Troast, Dawn M, Zhang, Ying, Cuozzo, John W, Keefe, Anthony D, Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M, Fedorov, Oleg, Huber, Kilian V. M, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V, Gorjánácz, Mátyás

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ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication von Koo, Seong Joo, Fernández-Montalván, Amaury E, Badock, Volker, Ott, Christopher J, Holton, Simon J, von Ahsen, Oliver, Toedling, Joern, Vittori, Sarah, Bradner, James E, Gorjánácz, Mátyás

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Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo von Siemeister, Gerhard, Mengel, Anne, Fernández-Montalván, Amaury E, Bone, Wilhelm, Schröder, Jens, Zitzmann-Kolbe, Sabine, Briem, Hans, Prechtl, Stefan, Holton, Simon J, Mönning, Ursula, von Ahsen, Oliver, Johanssen, Sandra, Cleve, Arwed, Pütter, Vera, Hitchcock, Marion, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik

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Halogenaromatische π‐Wechselwirkungen modulieren die Verweilzeit von Inhibitoren von Heroven, Christina, Georgi, Victoria, Ganotra, Gaurav K., Brennan, Paul, Wolfreys, Finn, Wade, Rebecca C., Fernández‐Montalván, Amaury E., Chaikuad, Apirat, Knapp, Stefan

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Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2 von Eggert, Erik, Hillig, Roman C, Koehr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D, ter Laak, Antonius, Lang, Tina, Fernandez-Montalvan, Amaury E, Badock, Volker, Weinmann, Hilmar, Hartung, Ingo V, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Kennedy, Steven, Li, Fengling, Vedadi, Masoud, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Stellfeld, Timo, Stresemann, Carlo

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Abstract 160: High target binding affinity with long lasting cellular target engagement and high dose intermittent schedule of PI3K inhibitor copanlisib contribute to the potent an... von Fernández-Montalván, Amaury E., Georgi, Victoria, Vasta, James, Glaeske, Sarah, Puetter, Vera, Robers, Matthew B., Moenning, Ursula, Sturz, Andrea, Lefranc, Julien, Ziegelbauer, Karl, Brands, Michael, Stegmann, Christian, Scott, William J., Liu, Ningshu

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Abstract 980: BAY-299, a novel chemical probe for in-depth analysis of the function of the bromodomain proteins BRPF2 and TAF1 von Bouche, Lea, Christ, Clara D., Siegel, Stephan, Tallant, Cynthia, Fernández-Montalván, Amaury E., Huber, Kilian V., Pütter, Verra, Müller, Susanne, Fedorov, Oleg, Laak, Antonius ter, Sugawara, Tatsuo, Stöckigt, Detlef, Meier, Julia, Holton, Simon J., Hartung, Ingo V., Haendler, Bernard

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Abstract 287: BAY 1816032, a novel BUB1 kinase inhibitor with potent antitumor activity von Siemeister, Gerhard, Mengel, Anne, Bone, Wilhelm, Schröder, Jens, Zitzmann-Kolbe, Sabine, Briem, Hans, Fernández-Montalván, Amaury E., Holton, Simon, Mönning, Ursula, Ahsen, Oliver von, Johanssen, Sandra, Cleve, Arwed, Hitchcock, Marion, Meyer, Kirstin, Nussbaum, Franz von, Brands, Michael, Mumberg, Dominik, Ziegelbauer, Karl

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Abstract 5084: Potent and isoform-selective ATAD2 bromodomain inhibitor with unprecedented chemical structure and mode of action von Fernández-Montalván, Amaury E., Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Holton, Simon J., Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James, Federov, Oleg, Huber, Kilian, Centrella, Paolo, Clark, Matthew A., Dumelin, Christoph E., Sigel, Eric A., Soutter, Holly S., Troast, Dawn M., Zhang, Ying, Cuozzo, John W., Keefe, Anthony D., Roche, Didier, Rodeschini, Vincent, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V., Gorjanacz, Matyas

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Binding kinetics in drug discovery - A current perspective von Georgi, Victoria, Andres, Dorothee, Fernandez-Montalvan, Amaury E, Stegmann, Christian M, Becker, Andreas, Mueller-Fahrnow, Anke

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Halogenaromatische π‐Wechselwirkungen modulieren die Verweilzeit von Inhibitoren von Heroven, Christina, Georgi, Victoria, Ganotra, Gaurav K., Brennan, Paul, Wolfreys, Finn, Wade, Rebecca C., Fernández‐Montalván, Amaury E., Chaikuad, Apirat, Knapp, Stefan

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ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication von Koo, Seong Joo, Fernández-Montalván, Amaury E, Badock, Volker, Ott, Christopher J, Holton, Simon J, von Ahsen, Oliver, Toedling, Joern, Vittori, Sarah, Bradner, James E, Gorjánácz, Mátyás

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Abstract 4691: Identification and characterization of BRPF1 bromodomain inhibitors von Haendler, Bernard, Bouché, Léa, Siegel, Stephan, Fernandez-Montalvan, Amaury E., Sugawara, Tatsuo, Meier, Julia, Knapp, Stefan, Gamble, Vicki

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