Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir von Tchesnokov, Egor P, Feng, Joy Y, Porter, Danielle P, Götte, Matthias

Volltext

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus von Gordon, Calvin J., Tchesnokov, Egor P., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

Volltext

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV von Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.

Volltext

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease von Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R

Volltext

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses von Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

Volltext

Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition von Liclican, Albert, Serafini, Loredana, Xing, Weimei, Czerwieniec, Gregg, Steiner, Bart, Wang, Ting, Brendza, Katherine M., Lutz, Justin D., Keegan, Kathleen S., Ray, Adrian S., Schultz, Brian E., Sakowicz, Roman, Feng, Joy Y.

Volltext

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM von Wong, Melanie H., Samal, Alexandra B., Lee, Mike, Vlach, Jiri, Novikov, Nikolai, Niedziela-Majka, Anita, Feng, Joy Y., Koltun, Dmitry O., Brendza, Katherine M., Kwon, Hyock Joo, Schultz, Brian E., Sakowicz, Roman, Saad, Jamil S., Papalia, Giuseppe A.

Volltext

Structural basis for substrate selection by the SARS-CoV-2 replicase von Malone, Brandon F., Perry, Jason K., Olinares, Paul Dominic B., Lee, Hery W., Chen, James, Appleby, Todd C., Feng, Joy Y., Bilello, John P., Ng, Honkit, Sotiris, Johanna, Ebrahim, Mark, Chua, Eugene Y. D., Mendez, Joshua H., Eng, Ed T., Landick, Robert, Götte, Matthias, Chait, Brian T., Campbell, Elizabeth A., Darst, Seth A.

Volltext

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells von Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P., Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P., Li, Li, Schultz, Brian E., Sakowicz, Roman, Smith, Bill J., Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y.

Volltext

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides von Arnold, Jamie J, Sharma, Suresh D, Feng, Joy Y, Ray, Adrian S, Smidansky, Eric D, Kireeva, Maria L, Cho, Aesop, Perry, Jason, Vela, Jennifer E, Park, Yeojin, Xu, Yili, Tian, Yang, Babusis, Darius, Barauskus, Ona, Peterson, Blake R, Gnatt, Averell, Kashlev, Mikhail, Zhong, Weidong, Cameron, Craig E

Volltext

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice von Martinez, David R., Schäfer, Alexandra, Leist, Sarah R., Li, Dapeng, Gully, Kendra, Yount, Boyd, Feng, Joy Y., Bunyan, Elaine, Porter, Danielle P., Cihlar, Tomas, Montgomery, Stephanie A., Haynes, Barton F., Baric, Ralph S., Nussenzweig, Michel C., Sheahan, Timothy P.

Volltext

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency von Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

Volltext

Interfering with nucleotide excision by the coronavirus 3'-to-5' exoribonuclease von Chinthapatla, Rukesh, Sotoudegan, Mohamad, Srivastava, Pankaj, Anderson, Thomas K, Moustafa, Ibrahim M, Passow, Kellan T, Kennelly, Samantha A, Moorthy, Ramkumar, Dulin, David, Feng, Joy Y, Harki, Daniel A, Kirchdoerfer, Robert N, Cameron, Craig E, Arnold, Jamie J

Volltext

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus von Feng, Joy Y, Xu, Yili, Barauskas, Ona, Perry, Jason K, Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E, Sakowicz, Roman, Ray, Adrian S

Volltext

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs von Barauskas, Ona, Xing, Weimei, Aguayo, Esmeralda, Willkom, Madeleine, Sapre, Annapurna, Clarke, Michael, Birkus, Gabriel, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y

Volltext

Addressing the selectivity and toxicity of antiviral nucleosides von Feng, Joy Y

Volltext

Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro von Radoshitzky, Sheli R., Iversen, Patrick, Lu, Xianghan, Zou, Jing, Kaptein, Suzanne J. F., Stuthman, Kelly S., Van Tongeren, Sean A., Steffens, Jesse, Gong, Ruoyu, Truong, Hoa, Sapre, Annapurna A., Yang, Huiling, Xie, Xiaodong, Chia, Jia Jun, Song, Zhijuan J., Leventhal, Stacey M., Chan, Josolyn, Shornikov, Alex, Zhang, Xin, Cowfer, David, Yu, Helen, Warren, Travis, Cihlar, Tomas, Porter, Danielle P., Neyts, Johan, Shi, Pei-Yong, Wells, Jay, Bilello, John P., Feng, Joy Y.

Volltext

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2 von Feng, Joy Y., Du Pont, Venice, Babusis, Darius, Gordon, Calvin J., Tchesnokov, Egor P., Perry, Jason K., Duong, Vincent, Vijjapurapu, Arya, Zhao, Xiaofeng, Chan, Julie, Cohen, Cal, Juneja, Kavita, Cihlar, Tomas, Götte, Matthias, Bilello, John P.

Volltext

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase von Brown, Ariane J., Won, John J., Graham, Rachel L., Dinnon, Kenneth H., Sims, Amy C., Feng, Joy Y., Cihlar, Tomas, Denison, Mark R., Baric, Ralph S., Sheahan, Timothy P.

Volltext

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action von Tchesnokov, Egor P., Gordon, Calvin J., Woolner, Emma, Kocinkova, Dana, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

Volltext