Radical Cyclization Approach to Spirocyclohexadienones von González-López de Turiso, Felix, Curran, Dennis P

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Concise synthesis of stereodefined, thiazole—containing cyclic hexa- and octapeptide relatives of the Lissoclinums, via cyclooligomerisation reactions von Bertram, Anna, Blake, Alexander J, Turiso, Felix González-López de, Hannam, Jeffery S, Jolliffe, Katrina A, Pattenden, Gerald, Skae, Michael

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Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors von Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors von Himmelbauer, Martin K, Xin, Zhili, Jones, J. Howard, Enyedy, Istvan, King, Kristopher, Marcotte, Douglas J, Murugan, Paramasivam, Santoro, Joseph C, Hesson, Thomas, Spilker, Kerri, Johnson, Joshua L, Luzzio, Michael J, Gilfillan, Rab, de Turiso, Felix Gonzalez-Lopez

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Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction von Rew, Yosup, Sun, Daqing, Gonzalez-Lopez De Turiso, Felix, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Deignan, Jeffrey, Fox, Brian M, Gustin, Darin, Huang, Xin, Jiang, Min, Jiao, Xianyun, Jin, Lixia, Kayser, Frank, Kopecky, David J, Li, Yihong, Lo, Mei-Chu, Long, Alexander M, Michelsen, Klaus, Oliner, Jonathan D, Osgood, Tao, Ragains, Mark, Saiki, Anne Y, Schneider, Steve, Toteva, Maria, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolineca... von Gonzalez-Lopez de Turiso, Felix, Hao, Xiaolin, Shin, Youngsook, Bui, Minna, Campuzano, Iain D. G, Cardozo, Mario, Dunn, Michelle C, Duquette, Jason, Fisher, Benjamin, Foti, Robert S, Henne, Kirk, He, Xiao, Hu, Yi-Ling, Kelly, Ron C, Johnson, Michael G, Lucas, Brian S, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D

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Radical and Palladium-Catalyzed Cyclizations to Cyclobutenes:  An Entry to the BCD Ring System of Penitrem D von Rivkin, Alexey, González-López de Turiso, Felix, Nagashima, Tadamichi, Curran, Dennis P

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Total Synthesis of the Furanocembrane bis-Deoxylophotoxin von Cases, Manuel, González-López de Turiso, Felix, Pattenden, Gerald

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Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo von Jones, J. Howard, Xin, Zhili, Himmelbauer, Martin, Dechantsreiter, Michael, Enyedy, Istvan, Hedde, Joseph, Fang, Terry, Coomaraswamy, Janaky, King, Kristopher W, Murugan, Paramasivam, Santoro, Joseph C, Hesson, Thomas, Walther, Dirk M, Wei, Ru, Zheng, Fengmei, Marcotte, Douglas J, Spilker, Kerri, Kumar, P. Rajesh, Liu, Ying, Gilfillan, Rab, Gonzalez-Lopez de Turiso, Felix

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Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis von Himmelbauer, Martin K., Bajrami, Bekim, Basile, Rebecca, Capacci, Andrew, Chen, TeYu, Choi, Colin K., Gilfillan, Rab, Gonzalez-Lopez de Turiso, Felix, Gu, Chungang, Hoemberger, Marc, Johnson, Douglas S., Jones, J. Howard, Kadakia, Ekta, Kirkland, Melissa, Lin, Edward Y., Liu, Ying, Ma, Bin, Magee, Tom, Mantena, Srinivasa, Marx, Isaac E., Metrick, Claire M., Mingueneau, Michael, Murugan, Paramasivam, Muste, Cathy A., Nadella, Prasad, Nevalainen, Marta, Parker Harp, Chelsea R., Pattaropong, Vatee, Pietrasiewicz, Alicia, Prince, Robin J., Purgett, Thomas J., Santoro, Joseph C., Schulz, Jurgen, Sciabola, Simone, Tang, Hao, Vandeveer, H. George, Wang, Ti, Yousaf, Zain, Helal, Christopher J., Hopkins, Brian T.

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Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo von Halkina, Tamara, Henderson, Jaclyn L, Lin, Edward Y, Himmelbauer, Martin K, Jones, J. Howard, Nevalainen, Marta, Feng, Jun, King, Kristopher, Rooney, Michael, Johnson, Joshua L, Marcotte, Douglas J, Chodaparambil, Jayanth V, Kumar, P. Rajesh, Patterson, Thomas A, Murugan, Paramasivam, Schuman, Eli, Wong, LaiYee, Hesson, Thomas, Lamore, Sarah, Bao, Channa, Calhoun, Michael, Certo, Hannah, Amaral, Brenda, Dillon, Gregory M, Gilfillan, Rab, de Turiso, Felix Gonzalez-Lopez

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Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune D... von Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.

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The Synthesis of Novel Thiazole Containing Cyclic Peptides via Cyclooligomerisation Reactions von Bertram, Anna, Hannam, Jeffery S., Jolliffe, Katrina A., González-López de Turiso, Felix, Pattenden, Gerald

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Synthetic studies towards furanocembrane diterpenes. A total synthesis of bis-deoxylophotoxin von Cases, Manuel, Gonzalez-Lopez de Turiso, Felix, Hadjisoteriou, Maria S, Pattenden, Gerald

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Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors von Sun, Daqing, Wang, Zhulun, Caille, Seb, DeGraffenreid, Michael, Gonzalez-Lopez de Turiso, Felix, Hungate, Randall, Jaen, Juan C., Jiang, Ben, Julian, Lisa D., Kelly, Ron, McMinn, Dustin L., Kaizerman, Jacob, Rew, Yosup, Sudom, Athena, Tu, Hua, Ursu, Stefania, Walker, Nigel, Willcockson, Maren, Yan, Xuelei, Ye, Qiuping, Powers, Jay P.

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Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors von Xin, Zhili, Himmelbauer, Martin K, Jones, J. Howard, Enyedy, Istvan, Gilfillan, Rab, Hesson, Thomas, King, Kristopher, Marcotte, Douglas J, Murugan, Paramasivam, Santoro, Joseph C, Gonzalez-Lopez de Turiso, Felix

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Synthesis of spirocyclopentene-indolines by intramolecular alkylidine insertion reactions von Whipp, Christopher J., de Turiso, Felix Gonzalez-Lopez

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Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors von Gonzalez-Lopez de Turiso, Felix, Shin, Youngsook, Brown, Matthew, Cardozo, Mario, Chen, Yi, Fong, David, Hao, Xiaolin, He, Xiao, Henne, Kirk, Hu, Yi-Ling, Johnson, Michael G, Kohn, Todd, Lohman, Julia, McBride, Helen J, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, Miner, Kent, Mohn, Deanna, Pattaropong, Vatee, Seganish, Jennifer, Simard, Jillian L, Wannberg, Sharon, Whittington, Douglas A, Yu, Gang, Cushing, Timothy D

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An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Condensation for the Synthesis of 4,4-Disubstituted Cyclohexane β-Keto Esters von DeGraffenreid, Michael R, Bennett, Sarah, Caille, Sebastien, Gonzalez-Lopez de Turiso, Felix, Hungate, Randall W, Julian, Lisa D, Kaizerman, Jacob A, McMinn, Dustin L, Rew, Yosup, Sun, Daqing, Yan, Xuelei, Powers, Jay P

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Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development von Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C

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