PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression von PARAISO, Kim H. T, YUN XIANG, RIBAS, Antoni, DALLA PALMA, Maurizia, NATHANSON, Katherine L, KOOMEN, John M, MESSINA, Jane L, SMALLEY, Keiran S. M, REBECCA, Vito W, ABEL, Ethan V, CHEN, Y. Ann, MUNKO, A. Cecilia, WOOD, Elizabeth, FEDORENKO, Inna V, SONDAK, Vernon K, ANDERSON, Alexander R. A

Volltext

Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma von Fedorenko, Inna V., Paraiso, Kim H.T., Smalley, Keiran S.M.

Volltext

BRAF Inhibition Generates a Host–Tumor Niche that Mediates Therapeutic Escape von Fedorenko, Inna V., Wargo, Jennifer A., Flaherty, Keith T., Messina, Jane L., Smalley, Keiran S.M.

Volltext

Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype von Paraiso, Kim H T, Das Thakur, Meghna, Fang, Bin, Koomen, John M, Fedorenko, Inna V, John, Jobin K, Tsao, Hensin, Flaherty, Keith T, Sondak, Vernon K, Messina, Jane L, Pasquale, Elena B, Villagra, Alejandro, Rao, Uma N, Kirkwood, John M, Meier, Friedegund, Sloot, Sarah, Gibney, Geoffrey T, Stuart, Darrin, Tawbi, Hussein, Smalley, Keiran S M

Volltext

Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy von Smalley, Keiran S.M., Fedorenko, Inna V., Kenchappa, Rajappa S., Sahebjam, Solmaz, Forsyth, Peter A.

Volltext

Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach von EUNJUNG KIM, REBECCA, Vito, FEDORENKO, Inna V, MESSINA, Jane L, MATHEW, Rahel, MARIA-ENGLER, Silvya S, BASANTA, David, SMALLEY, Keiran S. M, ANDERSON, Alexander R. A

Volltext

Evaluating Melanoma Drug Response and Therapeutic Escape with Quantitative Proteomics von Rebecca, Vito W., Wood, Elizabeth, Fedorenko, Inna V., Paraiso, Kim H.T., Haarberg, H. Eirik, Chen, Yi, Xiang, Yun, Sarnaik, Amod, Gibney, Geoffrey T., Sondak, Vernon K., Koomen, John M., Smalley, Keiran S.M.

Volltext

The complexity of microenvironment-mediated drug resistance von Fedorenko, Inna V, Smalley, Keiran S M

Volltext

Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma von Rebecca, Vito W., Massaro, Renato R., Fedorenko, Inna V., Sondak, Vernon K., Anderson, Alexander R. A., Kim, Eunjung, Amaravadi, Ravi K., Maria-Engler, Silvya S., Messina, Jane L., Gibney, Geoffrey T., Kudchadkar, Ragini R., Smalley, Keiran S. M.

Volltext

XL888 Limits Vemurafenib-Induced Proliferative Skin Events by Suppressing Paradoxical MAPK Activation von Phadke, Manali, Gibney, Geoffrey T., Rich, Carolyn J., Fedorenko, Inna V., Chen, Y. Ann, Kudchadkar, Ragini R., Sondak, Vernon K., Weber, Jeffrey, Messina, Jane L., Smalley, Keiran S.M.

Volltext

Phosphoproteomic analysis of basal and therapy-induced adaptive signaling networks in BRAF and NRAS mutant melanoma von Fedorenko, Inna V., Fang, Bin, Munko, Ana Cecelia, Gibney, Geoffrey T., Koomen, John M., Smalley, Keiran S. M.

Volltext

Melanoma genotypes and phenotypes get personal von Pimiento, Jose M, Larkin, Eileen M, Smalley, Keiran SM, Wiersma, Ginger L, Monks, Noel R, Fedorenko, Inna V, Peterson, Chelsea A, Nickoloff, Brian J

Volltext

A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature von Fedorenko, Inna V, Evernden, Brittany, Kenchappa, Rajappa S, Sahebjam, Solmaz, Ryzhova, Elena, Puskas, John, McIntosh, Linda, Caceres, Gisela, Magliocco, Anthony, Etame, Arnold, Harbour, J William, Smalley, Keiran S M, Forsyth, Peter A

Volltext

Amuvatinib has cytotoxic effects against NRAS-mutant melanoma but not BRAF-mutant melanoma von Fedorenko, Inna V, Fang, Bin, Koomen, John M, Gibney, Geoffrey T, Smalley, Keiran S M

Volltext

Inhibition of BRAF and BRAF+MEK drives a metastatic switch in melanoma von Smalley, Keiran SM, Fedorenko, Inna V

Volltext

NRAS mutant melanoma: biological behavior and future strategies for therapeutic management von Fedorenko, I V, Gibney, G T, Smalley, K S M

Volltext

Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells von Fedorenko, I V, Abel, E V, Koomen, J M, Fang, B, Wood, E R, Chen, Y A, Fisher, K J, Iyengar, S, Dahlman, K B, Wargo, J A, Flaherty, K T, Sosman, J A, Sondak, V K, Messina, J L, Gibney, G T, Smalley, K S M

Volltext

Activity-Based Protein Profiling Shows Heterogeneous Signaling Adaptations to BRAF Inhibition von Sharma, Ritin, Fedorenko, Inna, Spence, Paige T, Sondak, Vernon K, Smalley, Keiran S. M, Koomen, John M

Volltext

Abstract IA04: Using comprehensive proteomic approaches to map signaling adaptations to BRAF and BRAF/MEK inhibition von Fedorenko, Inna V., Paraiso, Kim H.T., Fang, Bin, Koomen, John M., Smalley, Keiran S.M.

Volltext

Abstract LB-C12: Functional proteomics elucidates signaling adaptation driven by combination therapy in BRAF mutant melanoma cell line models von Sharma, Ritin, Fedorenko, Inna, Koncarevic, Sasa, Mitra, Vikram, Selzer, Stefan, Boehm, Gitte, Pike, Ian, Smalley, Keiran, Koomen, John M.

Volltext