ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the GroEL Chaperonin von Clare, Daniel K., Vasishtan, Daven, Stagg, Scott, Quispe, Joel, Farr, George W., Topf, Maya, Horwich, Arthur L., Saibil, Helen R.

Volltext

Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury von Farr, George W., Hall, Christopher H., Farr, Susan M., Wade, Ramon, Detzel, Joshua M., Adams, Amielia G., Buch, Jasen M., Beahm, Derek L., Flask, Christopher A., Xu, Kui, LaManna, Joseph C., McGuirk, Paul R., Boron, Walter F., Pelletier, Marc F.

Volltext

Increased cerebral vascularization and decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice von Zhang, Yifan, Xu, Kui, Liu, Yuchi, Erokwu, Bernadette O, Zhao, Pan, Flask, Chris A, Ramos-Estebanez, Ciro, Farr, George W, LaManna, Joseph C, Boron, Walter F, Yu, Xin

Volltext

Two families of chaperonin: physiology and mechanism von Horwich, Arthur L, Fenton, Wayne A, Chapman, Eli, Farr, George W

Volltext

An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans von Wang, Jiou, Farr, George W, Hall, David H, Li, Fei, Furtak, Krystyna, Dreier, Lars, Horwich, Arthur L

Volltext

Loops in the Central Channel of ClpA Chaperone Mediate Protein Binding, Unfolding, and Translocation von Hinnerwisch, Jörg, Fenton, Wayne A., Furtak, Krystyna J., Farr, George W., Horwich, Arthur L.

Volltext

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS von Wang, Jiou, Farr, George W, Zeiss, Caroline J, Rodriguez-Gil, Diego J, Wilson, Jean H, Furtak, Krystyna, Rutkowski, D. Thomas, Kaufman, Randal J, Ruse, Cristian I, Yates, John R. III, Perrin, Steve, Feany, Mel B, Horwich, Arthur L

Volltext

Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes von Saibil, Helen R, Ranson, Neil A, Clare, Daniel K, Farr, George W, Houldershaw, David, Horwich, Arthur L

Volltext

Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules von Rojas, Marta, Farr, George W, Fernandez, Cesar F, Lauden, Laura, McCormack, John C, Wolin, Sandra L

Volltext

Topologies of a Substrate Protein Bound to the Chaperonin GroEL von Elad, Nadav, Farr, George W., Clare, Daniel K., Orlova, Elena V., Horwich, Arthur L., Saibil, Helen R.

Volltext

Global Aggregation of Newly Translated Proteins in an Escherichia coli Strain Deficient of the Chaperonin GroEL von Chapman, Eli, Farr, George W., Usaite, Renata, Furtak, Krystyna, Fenton, Wayne A., Chaudhuri, Tapan K., Hondorp, Elise R., Matthews, Rowena G., Wolf, Sharon G., Yates, John R., Pypaert, Marc, Horwich, Arthur L.

Volltext

Perturbed ATPase Activity and Not "Close Confinement" of Substrate in the Cis Cavity Affects Rates of Folding by Tail-Multiplied GroEL von Farr, George W., Fenton, Wayne A., Horwich, Arthur L.

Volltext

Water channel aquaporin 4 is required for T cell receptor mediated lymphocyte activation von Nicosia, Michael, Lee, Juyeun, Beavers, Ashley, Kish, Danielle, Farr, George W, McGuirk, Paul R, Pelletier, Marc F, Lathia, Justin D, Fairchild, Robert L, Valujskikh, Anna

Volltext

GroEL−GroES-Mediated Protein Folding von Horwich, Arthur L, Farr, George W, Fenton, Wayne A

Volltext

Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking von Nicosia, Michael, Miyairi, Satoshi, Beavers, Ashley, Farr, George W., McGuirk, Paul R., Pelletier, Marc F., Valujskikh, Anna

Volltext

Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state von Chapman, Eli, Farr, George W, Fenton, Wayne A, Johnson, Steven M, Horwich, Arthur L

Volltext

Substrate Polypeptide Presents a Load on the Apical Domains of the Chaperonin GroEL von Motojima, Fumihiro, Chaudhry, Charu, Fenton, Wayne A., Farr, George W., Horwich, Arthur L.

Volltext

A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL von Chapman, Eli, Farr, George W., Furtak, Krystyna, Horwich, Arthur L.

Volltext

Multivalent Binding of Nonnative Substrate Proteins by the Chaperonin GroEL von Farr, George W, Furtak, Krystyna, Rowland, Matthew B, Ranson, Neil A, Saibil, Helen R, Kirchhausen, Tomas, Horwich, Arthur L

Volltext

Aquaporin 4 blockade improves survival of murine heart allografts subjected to prolonged cold ischemia von Ayasoufi, Katayoun, Kohei, Naoki, Nicosia, Michael, Fan, Ran, Farr, George W., McGuirk, Paul R., Pelletier, Marc F., Fairchild, Robert L., Valujskikh, Anna

Volltext