Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance von Fantin, Valeria R., St-Pierre, Julie, Leder, Philip

Volltext

Natural killer cell therapies von Vivier, Eric, Rebuffet, Lucas, Narni-Mancinelli, Emilie, Cornen, Stéphanie, Igarashi, Rob Y., Fantin, Valeria R.

Volltext

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy von Eng, Christina H., Wang, Zuncai, Tkach, Diane, Toral-Barza, Lourdes, Ugwonali, Savuth, Liu, Shanming, Fitzgerald, Stephanie L., George, Elizabeth, Frias, Elizabeth, Cochran, Nadire, De Jesus, Rowena, McAllister, Gregory, Hoffman, Gregory R., Bray, Kevin, Lemon, LuAnna, Lucas, Judy, Fantin, Valeria R., Abraham, Robert T., Murphy, Leon O., Nyfeler, Beat

Volltext

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models von Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

Volltext

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Bittinger, Mark A, Driggers, Edward M, Ward, Patrick S, Gross, Stefan, Su, Shinsan M, Liau, Linda M, Dang, Lenny, Fantin, Valeria R, Jang, Hyun Gyung, Marks, Kevin M, White, David W, Vander Heiden, Matthew G, Thompson, Craig B, Rabinowitz, Joshua D, Cantley, Lewis C, Keenan, Marie C, Prins, Robert M, Jin, Shengfang, Bennett, Bryson D, Yen, Katharine E

Volltext

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations von Zou, Helen Y., Li, Qiuhua, Engstrom, Lars D., West, Melissa, Appleman, Vicky, Wong, Katy A., McTigue, Michele, Deng, Ya-Li, Liu, Wei, Brooun, Alexei, Timofeevski, Sergei, McDonnell, Scott R. P., Jiang, Ping, Falk, Matthew D., Lappin, Patrick B., Affolter, Timothy, Nichols, Tim, Hu, Wenyue, Lam, Justine, Johnson, Ted W., Smeal, Tod, Charest, Al, Fantin, Valeria R.

Volltext

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation von Figueroa, Maria E., Abdel-Wahab, Omar, Lu, Chao, Ward, Patrick S., Patel, Jay, Shih, Alan, Li, Yushan, Bhagwat, Neha, Vasanthakumar, Aparna, Fernandez, Hugo F., Tallman, Martin S., Sun, Zhuoxin, Wolniak, Kristy, Peeters, Justine K., Liu, Wei, Choe, Sung E., Fantin, Valeria R., Paietta, Elisabeth, Löwenberg, Bob, Licht, Jonathan D., Godley, Lucy A., Delwel, Ruud, Valk, Peter J.M., Thompson, Craig B., Levine, Ross L., Melnick, Ari

Volltext

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad‐Based Tumor Genotyping von Borger, Darrell R., Tanabe, Kenneth K., Fan, Kenneth C., Lopez, Hector U., Fantin, Valeria R., Straley, Kimberly S., Schenkein, David P., Hezel, Aram F., Ancukiewicz, Marek, Liebman, Hannah M., Kwak, Eunice L., Clark, Jeffrey W., Ryan, David P., Deshpande, Vikram, Dias‐Santagata, Dora, Ellisen, Leif W., Zhu, Andrew X., Iafrate, A. John

Volltext

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations von Gross, Stefan, Cairns, Rob A, Minden, Mark D, Driggers, Edward M, Bittinger, Mark A, Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P, Su, Shinsan M, Dang, Lenny, Fantin, Valeria R, Mak, Tak W

Volltext

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Marks, Kevin M, Rabinowitz, Joshua D, Dang, Lenny, Gross, Stefan, Fantin, Valeria R, Keenan, Marie C, Driggers, Edward M, Bennett, Bryson D, Jang, Hyun Gyung, Liau, Linda M, Ward, Patrick S, Jin, Shengfang, Yen, Katharine E, Su, Shinsan M, Prins, Robert M, Vander Heiden, Matthew G, White, David W, Cantley, Lewis C, Thompson, Craig B, Bittinger, Mark A

Volltext

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate von Ward, Patrick S., Patel, Jay, Wise, David R., Abdel-Wahab, Omar, Bennett, Bryson D., Coller, Hilary A., Cross, Justin R., Fantin, Valeria R., Hedvat, Cyrus V., Perl, Alexander E., Rabinowitz, Joshua D., Carroll, Martin, Su, Shinsan M., Sharp, Kim A., Levine, Ross L., Thompson, Craig B.

Volltext

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2 von Amary, M Fernanda, Damato, Stephen, Halai, Dina, Eskandarpour, Malihe, Berisha, Fitim, Bonar, Fiona, McCarthy, Stan, Fantin, Valeria R, Straley, Kimberly S, Lobo, Samira, Aston, Will, Green, Claire L, Gale, Rosemary E, Tirabosco, Roberto, Futreal, Andrew, Campbell, Peter, Presneau, Nadège, Flanagan, Adrienne M

Volltext

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A von Quinlan, Casey L, Kaiser, Stephen E, Bolaños, Ben, Nowlin, Dawn, Grantner, Rita, Karlicek-Bryant, Shannon, Feng, Jun Li, Jenkinson, Stephen, Freeman-Cook, Kevin, Dann, Stephen G, Wang, Xiaoli, Wells, Peter A, Fantin, Valeria R, Stewart, Al E, Grant, Stephan K

Volltext

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy von Pope, Whitney B., Prins, Robert M., Albert Thomas, M., Nagarajan, Rajakumar, Yen, Katharine E., Bittinger, Mark A., Salamon, Noriko, Chou, Arthur P., Yong, William H., Soto, Horacio, Wilson, Neil, Driggers, Edward, Jang, Hyun G., Su, Shinsan M., Schenkein, David P., Lai, Albert, Cloughesy, Timothy F., Kornblum, Harley I., Wu, Hong, Fantin, Valeria R., Liau, Linda M.

Volltext

Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion von Shanware, Naval P., Bray, Kevin, Eng, Christina H., Wang, Fang, Follettie, Maximillian, Myers, Jeremy, Fantin, Valeria R., Abraham, Robert T.

Volltext

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockad... von Gomes, Bruno, Driessens, Gregory, Bartlett, Derek, Cai, Danying, Cauwenberghs, Sandra, Crosignani, Stefano, Dalvie, Deepak, Denies, Sofie, Dillon, Christopher P, Fantin, Valeria R, Guo, Jie, Letellier, Marie-Claire, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Pirson, Romain, Rabolli, Virginie, Ray, Chad, Streiner, Nicole, Torti, Vince R, Tsaparikos, Konstantinos, Van den Eynde, Benoit J, Wythes, Martin, Yao, Li-Chin, Zheng, Xianxian, Tumang, Joseph, Kraus, Manfred

Volltext

Mechanisms of Resistance to Histone Deacetylase Inhibitors and Their Therapeutic Implications von FANTIN, Valeria R, RICHON, Victoria M

Volltext

Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study von GALANIS, Evanthia, JAECKLE, Kurt A, RICHON, Victoria M, SCHEITHAUER, Bernd, GIANNINI, Caterina, FLYNN, Patrick J, MOORE, Dennis F, ZWIEBEL, James, BUCKNER, Jan C, MAURER, Matthew J, REID, Joel M, AMES, Matthew M, HARDWICK, James S, REILLY, John F, LOBODA, Andrey, NEBOZHYN, Michael, FANTIN, Valeria R

Volltext

Recurrent SETBP1 mutations in atypical chronic myeloid leukemia von Piazza, Rocco, Valletta, Simona, Winkelmann, Nils, Redaelli, Sara, Spinelli, Roberta, Pirola, Alessandra, Antolini, Laura, Mologni, Luca, Donadoni, Carla, Papaemmanuil, Elli, Schnittger, Susanne, Kim, Dong-Wook, Boultwood, Jacqueline, Rossi, Fabio, Gaipa, Giuseppe, De Martini, Greta P, di Celle, Paola Francia, Jang, Hyun Gyung, Fantin, Valeria, Bignell, Graham R, Magistroni, Vera, Haferlach, Torsten, Pogliani, Enrico Maria, Campbell, Peter J, Chase, Andrew J, Tapper, William J, Cross, Nicholas C P, Gambacorti-Passerini, Carlo

Volltext

Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production von Du, Xiaohui, Moore, Jared, Blank, Brian R, Eksterowicz, John, Sutimantanapi, Dena, Yuen, Natalie, Metzger, Todd, Chan, Brenda, Huang, Tom, Chen, Xi, Chen, Yuping, Duong, Frank, Kong, Wayne, Chang, Jae H, Sun, Jessica, Zavorotinskaya, Tatiana, Ye, Qiuping, Junttila, Melissa R, Ndubaku, Chudi, Friedman, Lori S, Fantin, Valeria R, Sun, Daqing

Volltext