Structure Modification of FXR Antagonistic Chalcones and Their Inhibitory Effects on NSCLC Cell Proliferation and Metastasis von Niu, Shuaishuai, Zhang, Guoning, Wang, Na, Lv, Guangyao, Liu, Jinsong, Wang, Hongbo, Fang, Wei‐Shuo

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Taxanes convert regions of perturbed microtubule growth into rescue sites von Rai, Ankit, Liu, Tianyang, Glauser, Simon, Katrukha, Eugene A., Estévez-Gallego, Juan, Rodríguez-García, Ruddi, Fang, Wei-Shuo, Díaz, J. Fernando, Steinmetz, Michel O., Altmann, Karl-Heinz, Kapitein, Lukas C., Moores, Carolyn A., Akhmanova, Anna

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Targeting the tubulin C-terminal tail by charged small molecules von Li, Shuo, Mori, Mattia, Yang, Mingyan, Elfazazi, Soumia, Hortigüela, Rafael, Chan, Peter, Feng, Xinyue, Risinger, April, Yang, Zhiyou, Oliva, María Ángela, Fernando Díaz, J, Fang, Wei-Shuo

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Structural insight into the stabilization of microtubules by taxanes von Prota, Andrea E, Lucena-Agell, Daniel, Ma, Yuntao, Estevez-Gallego, Juan, Li, Shuo, Bargsten, Katja, Josa-Prado, Fernando, Altmann, Karl-Heinz, Gaillard, Natacha, Kamimura, Shinji, Mühlethaler, Tobias, Gago, Federico, Oliva, Maria A, Steinmetz, Michel O, Fang, Wei-Shuo, Díaz, J Fernando

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Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties von Sun, De-Yang, Cheng, Chen, Moschke, Katrin, Huang, Jian, Fang, Wei-Shuo

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Synthesis and Cytotoxicity of 7,9- O -Linked Macrocyclic C-Seco Taxoids von Zhao, Yu, Wang, Tian-En, Mills, Alberto, Gago, Federico, Fang, Wei-Shuo

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Discovery of Farnesoid X Receptor Antagonists Based on a Library of Oleanolic Acid 3-O-Esters through Diverse Substituent Design and Molecular Docking Methods von Wang, Shao-Rong, Xu, Tingting, Deng, Kai, Wong, Chi-Wai, Liu, Jinsong, Fang, Wei-Shuo

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Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breas... von Chen, Li-Qing, Huang, Wei, Gao, Zhong-Gao, Fang, Wei-Shuo, Jin, Ming-Ji

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A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding ene... von Coderch, Claire, Tang, Yong, Klett, Javier, Zhang, Shu-En, Ma, Yun-Tao, Shaorong, Wang, Matesanz, Ruth, Pera, Benet, Canales, Angeles, Jiménez-Barbero, Jesús, Morreale, Antonio, Díaz, J Fernando, Fang, Wei-Shuo, Gago, Federico

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Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in v... von Ma, Yuntao, Josa-Prado, Fernando, Essif, Jacob Nathaniel, Liu, Shuqi, Li, Shuo, Lucena-Agell, Daniel, Chan, Peter YW, Goossens, Kenneth, Hortigüela, Rafael, Matesanz, Ruth, Wang, Yingjie, Gago, Federico, Wang, Hongbo, Risinger, April, Diaz, J. Fernando, Fang, Wei-Shuo

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Discovery of 12β-oxygenated oleanolic acid alkyl esters as potent and selective FXR modulators exhibiting hyperglycemia amelioration in vivo von Wang, Shaorong, Huan, Yi, Niu, Shuaishuai, Cao, Hui, Yang, Mingyan, Zhou, Xinyue, Gao, Xuefeng, Wang, Xing, Shen, Zhufang, Fang, Wei-Shuo

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A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility von Ma, Yun-Tao, Yang, Yanting, Cai, Pei, Sun, De-Yang, Sánchez-Murcia, Pedro A, Zhang, Xiao-Ying, Jia, Wen-Qiang, Lei, Lei, Guo, Mengqi, Gago, Federico, Wang, Hongbo, Fang, Wei-Shuo

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On the Chemical Constituents of Dipsacus asper von Tian, Xiao-Yan, Wang, Ying-Hong, Liu, Hong-Yue, Yu, Shi-Shan, Fang, Wei-Shuo

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A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro von Cai, Pei, Lu, Peihua, Sharom, Frances J, Fang, Wei-Shuo

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BACE1 (Beta-Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta von Tian, Xiao-Yan, Zhao, Ying, Yu, Shi-Shan, Fang, Wei-Shuo

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Synthesis and biological activities of high affinity taxane-based fluorescent probes von Li, Xuan, Barasoain, Isabel, Matesanz, Ruth, Fernando Díaz, J., Fang, Wei-Shuo

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Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR von Fang, Wei-Shuo, Sun, De-yang, Yang, Shuang, Cheng, Chen, Moschke, Katrin, Li, Tianqi, Sun, Shanshan, Lichtenthaler, Stefan F., Huang, Jian, Wang, Yinghong

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Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprot... von Tang, Yong, Rodríguez-Salarichs, Javier, Zhao, Yu, Cai, Pei, Estévez-Gallego, Juan, Balaguer-Pérez, Francisco, Redondo Horcajo, Mariano, Lucena-Agell, Daniel, Barasoain, Isabel, Díaz, J. Fernando, Fang, Wei-Shuo

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Overcoming Tumor Drug Resistance with High-Affinity Taxanes: A SAR Study of C2-Modified 7-Acyl-10-Deacetyl Cephalomannines von Yang, Chun-Gang, Barasoain, Isabel, Li, Xuan, Matesanz, Ruth, Liu, Ronghua, Sharom, Frances J., Yin, Da-Li, Díaz, J. Fernando, Fang, Wei-Shuo

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Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances von Matesanz, Ruth, Trigili, Chiara, Rodríguez-Salarichs, Javier, Zanardi, Ilaria, Pera, Benet, Nogales, Aurora, Fang, Wei-Shuo, Jímenez-Barbero, Jesús, Canales, Ángeles, Barasoain, Isabel, Ojima, Iwao, Díaz, J. Fernando

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