Development of synthetic lethality anticancer therapeutics von Fang, Bingliang

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mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation von Zhang, Yilei, Swanda, Robert V., Nie, Litong, Liu, Xiaoguang, Wang, Chao, Lee, Hyemin, Lei, Guang, Mao, Chao, Koppula, Pranavi, Cheng, Weijie, Zhang, Jie, Xiao, Zhenna, Zhuang, Li, Fang, Bingliang, Chen, Junjie, Qian, Shu-Bing, Gan, Boyi

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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer von Liu, Xiaoguang, Olszewski, Kellen, Zhang, Yilei, Lim, Esther W., Shi, Jiejun, Zhang, Xiaoshan, Zhang, Jie, Lee, Hyemin, Koppula, Pranavi, Lei, Guang, Zhuang, Li, You, M. James, Fang, Bingliang, Li, Wei, Metallo, Christian M., Poyurovsky, Masha V., Gan, Boyi

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RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies von Fang, Bingliang

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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma von Wang, Michael L, Rule, Simon, Martin, Peter, Goy, Andre, Auer, Rebecca, Kahl, Brad S, Jurczak, Wojciech, Advani, Ranjana H, Romaguera, Jorge E, Williams, Michael E, Barrientos, Jacqueline C, Chmielowska, Ewa, Radford, John, Stilgenbauer, Stephan, Dreyling, Martin, Jedrzejczak, Wieslaw Wiktor, Johnson, Peter, Spurgeon, Stephen E, Li, Lei, Zhang, Liang, Newberry, Kate, Ou, Zhishuo, Cheng, Nancy, Fang, Bingliang, McGreivy, Jesse, Clow, Fong, Buggy, Joseph J, Chang, Betty Y, Beaupre, Darrin M, Kunkel, Lori A, Blum, Kristie A

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Introduction to this Special Issue: “Biomarker Discovery and Precision Medicine” von Fang, Bingliang

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Differential Expression of Viral Transcripts From Single-Cell RNA Sequencing of Moderate and Severe COVID-19 Patients and Its Implications for Case Severity von Liu, Teng, Jia, Peilin, Fang, Bingliang, Zhao, Zhongming

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Mechanisms of resistance to TRAIL-induced apoptosis in cancer von Zhang, Lidong, Fang, Bingliang

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Structure-based classification predicts drug response in EGFR-mutant NSCLC von Robichaux, Jacqulyne P., Le, Xiuning, Vijayan, R. S. K., Hicks, J. Kevin, Heeke, Simon, Elamin, Yasir Y., Lin, Heather Y., Udagawa, Hibiki, Skoulidis, Ferdinandos, Tran, Hai, Varghese, Susan, He, Junqin, Zhang, Fahao, Nilsson, Monique B., Hu, Lemei, Poteete, Alissa, Rinsurongkawong, Waree, Zhang, Xiaoshan, Ren, Chenghui, Liu, Xiaoke, Hong, Lingzhi, Zhang, Jianjun, Diao, Lixia, Madison, Russell, Schrock, Alexa B., Saam, Jennifer, Raymond, Victoria, Fang, Bingliang, Wang, Jing, Ha, Min Jin, Cross, Jason B., Gray, Jhanelle E., Heymach, John V.

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Immunotherapy for non-small cell lung cancers: biomarkers for predicting responses and strategies to overcome resistance von Pu, Xingxiang, Wu, Lin, Su, Dan, Mao, Weimin, Fang, Bingliang

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Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer von Lissanu Deribe, Yonathan, Sun, Yuting, Terranova, Christopher, Khan, Fatima, Martinez-Ledesma, Juan, Gay, Jason, Gao, Guang, Mullinax, Robert A., Khor, Tin, Feng, Ningping, Lin, Yu-Hsi, Wu, Chia-Chin, Reyes, Claudia, Peng, Qian, Robinson, Frederick, Inoue, Akira, Kochat, Veena, Liu, Chang-Gong, Asara, John M., Moran, Cesar, Muller, Florian, Wang, Jing, Fang, Bingliang, Papadimitrakopoulou, Vali, Wistuba, Ignacio I., Rai, Kunal, Marszalek, Joseph, Futreal, P. Andrew

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B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy von Zhang, Leo, Nomie, Krystle, Zhang, Hui, Bell, Taylor, Pham, Lan, Kadri, Sabah, Segal, Jeremy, Li, Shaoying, Zhou, Shouhao, Santos, David, Richard, Shawana, Sharma, Shruti, Chen, Wendy, Oriabure, Onyekachukwu, Liu, Yang, Huang, Shengjian, Guo, Hui, Chen, Zhihong, Tao, Wenjing, Li, Carrie, Wang, Jack, Fang, Bingliang, Wang, Jacqueline, Li, Lei, Badillo, Maria, Ahmed, Makhdum, Thirumurthi, Selvi, Huang, Steven Y, Shao, Yiping, Lam, Laura, Yi, Qing, Wang, Y Lynn, Wang, Michael

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An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses von Meraz, Ismail M, Majidi, Mourad, Meng, Feng, Shao, RuPing, Ha, Min Jin, Neri, Shinya, Fang, Bingliang, Lin, Steven H, Tinkey, Peggy T, Shpall, Elizabeth J, Morris, Jeffrey, Roth, Jack A

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Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations von Pairawan, Seyed, Akcakanat, Argun, Kopetz, Scott, Tapia, Coya, Zheng, Xiaofeng, Chen, Huiqin, Ha, Min Jin, Rizvi, Yasmeen, Holla, Vijaykumar, Wang, Jing, Evans, Kurt W., Zhao, Ming, Busaidy, Naifa, Fang, Bingliang, Roth, Jack A., Dumbrava, Ecaterina Ileana, Meric-Bernstam, Funda

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CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts von Huang, Licai, Wang, Jing, Fang, Bingliang, Meric-Bernstam, Funda, Roth, Jack A., Ha, Min Jin

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Auranofin-mediated inhibition of PI3K/AKT/mTOR axis and anticancer activity in non-small cell lung cancer cells von Li, Hongyu, Hu, Jing, Wu, Shuhong, Wang, Li, Cao, Xiaobo, Zhang, Xiaoshan, Dai, Bingbing, Cao, Mengru, Shao, Ruping, Zhang, Ran, Majidi, Mourad, Ji, Lin, Heymach, John V, Wang, Michael, Pan, Shiyang, Minna, John, Mehran, Reza J, Swisher, Stephen G, Roth, Jack A, Fang, Bingliang

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Non‐canonical cMet regulation by vimentin mediates Plk1 inhibitor–induced apoptosis von Singh, Ratnakar, Peng, Shaohua, Viswanath, Pavitra, Sambandam, Vaishnavi, Shen, Li, Rao, Xiayu, Fang, Bingliang, Wang, Jing, Johnson, Faye M

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Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells von Zhou, Hongyu, Wu, Shuhong, Zhai, Shumei, Liu, Aifeng, Sun, Ying, Li, Rongshi, Zhang, Ying, Ekins, Sean, Swaan, Peter W, Fang, Bingliang, Zhang, Bin, Yan, Bing

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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells von Pataer, Apar, Ozpolat, Bulent, Shao, RuPing, Cashman, Neil R., Plotkin, Steven S., Samuel, Charles E., Lin, Steven H., Kabil, Nashwa N., Wang, Jing, Majidi, Mourad, Fang, Bingliang, Roth, Jack A., Vaporciyan, Ara A., Wistuba, Ignacio I., Hung, Mien-Chie, Swisher, Stephen G.

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Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer von Hao, Chuncheng, Wang, Li, Peng, Shaohua, Cao, Mengru, Li, Hongyu, Hu, Jing, Huang, Xiao, Liu, Wei, Zhang, Hui, Wu, Shuhong, Pataer, Apar, Heymach, John V, Eterovic, Agda Karina, Zhang, Qingxiu, Shaw, Kenna R, Chen, Ken, Futreal, Andrew, Wang, Michael, Hofstetter, Wayne, Mehran, Reza, Rice, David, Roth, Jack A, Sepesi, Boris, Swisher, Stephen G, Vaporciyan, Ara, Walsh, Garrett L, Johnson, Faye M, Fang, Bingliang

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