Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia von Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.

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Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases von Venkat, Aarya, Watterson, Grace, Byrne, Dominic P, O'Boyle, Brady, Shrestha, Safal, Gravel, Nathan, Fairweather, Emma E, Daly, Leonard A, Bunn, Claire, Yeung, Wayland, Aggarwal, Ishan, Katiyar, Samiksha, Eyers, Claire E, Eyers, Patrick A, Kannan, Natarajan

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sul... von Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib von James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J

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The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity von Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

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Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase von Hamilton, Niall M, Dawson, Martin, Fairweather, Emma E, Hamilton, Nicola S, Hitchin, James R, James, Dominic I, Jones, Stuart D, Jordan, Allan M, Lyons, Amanda J, Small, Helen F, Thomson, Graeme J, Waddell, Ian D, Ogilvie, Donald J

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments von Hitchin, James R., Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J., Fairweather, Emma E., Hutton, Colin, Jordan, Allan M., McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J., Waddell, Ian, Ogilvie, Donald J.

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Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases von Venkat, Aarya, Watterson, Grace, Byrne, Dominic P, O'Boyle, Brady, Shrestha, Safal, Gravel, Nathan, Fairweather, Emma E, Daly, Leonard A, Bunn, Claire, Yeung, Wayland, Aggarwal, Ishan, Katiyar, Samiksha, Eyers, Claire E, Eyers, Patrick A, Kannan, Natarajan

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Development and evaluation of selective, reversible LSD1 inhibitors derived from fragmentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00226h von Hitchin, James R, Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J, Fairweather, Emma E, Hutton, Colin, Jordan, Allan M, McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J, Waddell, Ian, Ogilvie, Donald J

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Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG):Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulf... von Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie Ann, Waddell, Ian D, Ogilvie, Donald J

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Increased toxin expression in a Clostridium difficile mfd mutant von Willing, Stephanie E, Richards, Emma J, Sempere, Lluis, Dale, Aaron G, Cutting, Simon M, Fairweather, Neil F

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Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease von Tumbale, Percy, Schellenberg, Matthew J, Mueller, Geoffrey A, Fairweather, Emma, Watson, Mandy, Little, Jessica N, Krahn, Juno, Waddell, Ian, London, Robert E, Williams, R Scott

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Fasciola hepatica: time-dependent disruption of spermatogenesis following in vivo treatment with triclabendazole von Toner, Emma, Brennan, Gerard P., Hanna, Robert E. B., Edgar, Hillary W. J., Fairweather, Ian

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Increased toxin expression in a Clostridium difficile mfd mutant von Willing, Stephanie E, Richards, Emma J, Sempere, Lluis, Dale, Aaron G, Cutting, Simon M, Fairweather, Neil F

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