"Designer Acids": Combined Acid Catalysis for Asymmetric Synthesis von Yamamoto, Hisashi, Futatsugi, Kentaro

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Stereoselective Construction of Halogenated Quaternary Stereogenic Centers via Catalytic Asymmetric Diels−Alder Reaction von Shibatomi, Kazutaka, Futatsugi, Kentaro, Kobayashi, Fumito, Iwasa, Seiji, Yamamoto, Hisashi

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs von Sun, Hao, Piotrowski, David W, Orr, Suvi T M, Warmus, Joseph S, Wolford, Angela C, Coffey, Steven B, Futatsugi, Kentaro, Zhang, Yinsheng, Vaz, Alfin D N

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Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries von Londregan, Allyn T., Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Boehm, Markus, Carpino, Philip A., Chin, Janice E., Janssen, Ann M., Roush, Nicole S., Buxton, Joanne, Hinchey, Terri

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Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor von Mascitti, Vincent, Stevens, Benjamin D., Choi, Chulho, McClure, Kim F., Guimarães, Cristiano R.W., Farley, Kathleen A., Munchhof, Michael J., Robinson, Ralph P., Futatsugi, Kentaro, Lavergne, Sophie Y., Lefker, Bruce A., Cornelius, Peter, Bonin, Paul D., Kalgutkar, Amit S., Sharma, Raman, Chen, Yue

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Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2) von Pabst, Brandon, Futatsugi, Kentaro, Li, Qifang, Ahn, Kay

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Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat von Sharma, Raman, Dowling, Matthew S., Futatsugi, Kentaro, Kalgutkar, Amit S.

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Optimization of triazole-based TGR5 agonists towards orally available agents von Futatsugi, Kentaro, Bahnck, Kevin B., Brenner, Martin B., Buxton, Joanne, Chin, Janice E., Coffey, Steven B., Dubins, Jeffrey, Flynn, Declan, Gautreau, Denise, Guzman-Perez, Angel, Hadcock, John R., Hepworth, David, Herr, Michael, Hinchey, Terri, Janssen, Ann M., Jennings, Sandra M., Jiao, Wenhua, Lavergne, Sophie Y., Li, Bryan, Li, Mei, Munchhof, Michael J., Orr, Suvi T. M., Piotrowski, David W., Roush, Nicole S., Sammons, Matthew, Stevens, Benjamin D., Storer, Gregory, Wang, Jian, Warmus, Joseph S., Wei, Liuqing, Wolford, Angela C.

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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis von Futatsugi, Kentaro, Cabral, Shawn, Kung, Daniel W., Huard, Kim, Lee, Esther, Boehm, Markus, Bauman, Jonathan, Clark, Ronald W., Coffey, Steven B., Crowley, Collin, Dechert-Schmitt, Anne-Marie, Dowling, Matthew S., Dullea, Robert, Gosset, James R., Kalgutkar, Amit S., Kou, Kou, Li, Qifang, Lian, Yajing, Loria, Paula M., Londregan, Allyn T., Niosi, Mark, Orozco, Christine, Pettersen, John C., Pfefferkorn, Jeffrey A., Polivkova, Jana, Ross, Trenton T., Sharma, Raman, Stock, Ingrid A., Tesz, Gregory, Wisniewska, Hanna, Goodwin, Bryan, Price, David A.

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Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5) von Huard, Kim, Brown, Janice, Jones, Jessica C., Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B., Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E., Magee, Thomas V., Uccello, Daniel P., Loria, Paula, Di, Li, Gosset, James R., Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A., Erion, Derek M.

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Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life von Filipski, Kevin J., Edmonds, David J., Garnsey, Michelle R., Smaltz, Daniel J., Coffman, Karen, Futatsugi, Kentaro, Lee, Jack, O’Neil, Steven V., Wright, Ann, Nason, Deane, Gosset, James R., Orozco, Christine C., Blackler, Dan, Fakhoury, Guila, Gutierrez, Jemy A., Perez, Sylvie, Ross, Trenton, Stock, Ingrid, Tesz, Gregory, Dullea, Robert

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Identification of Morpholino-2 H -pyrido[3,2- b ][1,4]oxazin-3(4 H )-ones as Nonsteroidal Mineralocorticoid Antagonists von Piotrowski, David W., Futatsugi, Kentaro, Casimiro-Garcia, Agustin, Wei, Liuqing, Sammons, Matthew F., Herr, Michael, Jiao, Wenhua, Lavergne, Sophie Y., Coffey, Steven B., Wright, Stephen W., Song, Kun, Loria, Paula M., Banker, Mary Ellen, Petersen, Donna N., Bauman, Jonathan

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Optimization of amide-based EP3 receptor antagonists von Lee, Esther C.Y., Futatsugi, Kentaro, Arcari, Joel T., Bahnck, Kevin, Coffey, Steven B., Derksen, David R., Kalgutkar, Amit S., Loria, Paula M., Sharma, Raman

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From partial to full agonism: Identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor von Futatsugi, Kentaro, Mascitti, Vincent, Guimarães, Cristiano R.W., Morishita, Nao, Cai, Cuiman, DeNinno, Michael P., Gao, Hua, Hamilton, Michael D., Hank, Richard, Harris, Anthony R., Kung, Daniel W., Lavergne, Sophie Y., Lefker, Bruce A., Lopaze, Michael G., McClure, Kim F., Munchhof, Michael J., Preville, Cathy, Robinson, Ralph P., Wright, Stephen W., Bonin, Paul D., Cornelius, Peter, Chen, Yue, Kalgutkar, Amit S.

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Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists von Piotrowski, David W, Futatsugi, Kentaro, Warmus, Joseph S, Orr, Suvi T. M, Freeman-Cook, Kevin D, Londregan, Allyn T, Wei, Liuqing, Jennings, Sandra M, Herr, Michael, Coffey, Steven B, Jiao, Wenhua, Storer, Gregory, Hepworth, David, Wang, Jian, Lavergne, Sophie Y, Chin, Janice E, Hadcock, John R, Brenner, Martin B, Wolford, Angela C, Janssen, Ann M, Roush, Nicole S, Buxton, Joanne, Hinchey, Terri, Kalgutkar, Amit S, Sharma, Raman, Flynn, Declan A

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DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS von Futatsugi Kentaro

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Asymmetric protonation of lithium enolates of alpha-amino acid derivatives with alpha-amino acid-based chiral Brønsted acids von Futatsugi, Kentaro, Yanagisawa, Akira, Yamamoto, Hisashi

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Kombinierte Säurekatalyse in der asymmetrischen Synthese durch “Designer‐Säuren” von Yamamoto, Hisashi, Futatsugi, Kentaro

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Optimization of triazole-based TGR5 agonists towards orally available agentsElectronic supplementary information (ESI) available: Detailed experimental procedures for synthesis of... von Futatsugi, Kentaro, Bahnck, Kevin B, Brenner, Martin B, Buxton, Joanne, Chin, Janice E, Coffey, Steven B, Dubins, Jeffrey, Flynn, Declan, Gautreau, Denise, Guzman-Perez, Angel, Hadcock, John R, Hepworth, David, Herr, Michael, Hinchey, Terri, Janssen, Ann M, Jennings, Sandra M, Jiao, Wenhua, Lavergne, Sophie Y, Li, Bryan, Li, Mei, Munchhof, Michael J, Orr, Suvi T. M, Piotrowski, David W, Roush, Nicole S, Sammons, Matthew, Stevens, Benjamin D, Storer, Gregory, Wang, Jian, Warmus, Joseph S, Wei, Liuqing, Wolford, Angela C

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NOVEL 5-CYCLOPROYLQUINOLINE DERIVATIVES AS PLPRO INHIBITORS von DICKSON, John Kenneth Jr, VACCA, Joseph Patrick, WARMUS, Joseph Scott, FUTATSUGI, Kentaro, KIENLE, Maryline Dong, SMALTZ, Daniel Jonathan

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