Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1 von Nakanishi, Yoshito, Akiyama, Nukinori, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Satoh, Yasuko, Ishii, Nobuya, Aoki, Masahiro

Volltext

Determination of starting dose of the T cell-redirecting bispecific antibody ERY974 targeting glypican-3 in first-in-human clinical trial von Komatsu, Shun-ichiro, Kayukawa, Yoko, Miyazaki, Yoko, Kaneko, Akihisa, Ikegami, Hisashi, Ishiguro, Takahiro, Nakamura, Mikiko, Frings, Werner, Ono, Natsuki, Sakata, Kiyoaki, Fujii, Toshihiko, Kishishita, Shohei, Kitazawa, Takehisa, Endo, Mika, Sano, Yuji

Volltext

Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer von Tanaka, Hiroshi, Sase, Hitoshi, Tsukaguchi, Toshiyuki, Hasegawa, Masami, Tanimura, Hiromi, Yoshida, Miyuki, Sakata, Kiyoaki, Fujii, Toshihiko, Tachibana, Yukako, Takanashi, Kenji, Higashida, Atsuko, Hasegawa, Kiyoshi, Ono, Yoshiyuki, Oikawa, Nobuhiro, Mio, Toshiyuki

Volltext

ERK Signal Suppression and Sensitivity to CH5183284/Debio 1347, a Selective FGFR Inhibitor von Nakanishi, Yoshito, Mizuno, Hideaki, Sase, Hitoshi, Fujii, Toshihiko, Sakata, Kiyoaki, Akiyama, Nukinori, Aoki, Yuko, Aoki, Masahiro, Ishii, Nobuya

Volltext

Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non‐small‐cell lung cancer von Ono, Naomi, Yamazaki, Toshikazu, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Suda, Atsushi, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

Volltext

Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)‐overexpressing cancers von Ono, Naomi, Yamazaki, Toshikazu, Nakanishi, Yoshito, Fujii, Toshihiko, Sakata, Kiyoaki, Tachibana, Yukako, Suda, Atsushi, Hada, Kihito, Miura, Takaaki, Sato, Shigeo, Saitoh, Ryoichi, Nakano, Kohnosuke, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

Volltext

Development of a targeted flip-in system in avian DT40 cells von Kobayashi, Kaori, Fujii, Toshihiko, Asada, Ryuta, Ooka, Masato, Hirota, Kouji

Volltext

In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan von Yamazaki, Toshikazu, Inagaki, Yukiko, Fujii, Toshihiko, Ohwada, Jun, Tsukazaki, Masao, Umeda, Isao, Kobayashi, Kazuko, Shimma, Nobuo, Page, Malcolm G.P, Arisawa, Mikio

Volltext

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase von Masubuchi, Miyako, Ebiike, Hirosato, Kawasaki, Ken-ichi, Sogabe, Satoshi, Morikami, Kenji, Shiratori, Yasuhiko, Tsujii, Shinji, Fujii, Toshihiko, Sakata, Kiyoaki, Hayase, Michiko, Shindoh, Hidetoshi, Aoki, Yuko, Ohtsuka, Tatsuo, Shimma, Nobuo

Volltext

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3 von Kawasaki, Ken-ichi, Masubuchi, Miyako, Morikami, Kenji, Sogabe, Satoshi, Aoyama, Tsunehisa, Ebiike, Hirosato, Niizuma, Satoshi, Hayase, Michiko, Fujii, Toshihiko, Sakata, Kiyoaki, Shindoh, Hidetoshi, Shiratori, Yasuhiko, Aoki, Yuko, Ohtsuka, Tatsuo, Shimma, Nobuo

Volltext

The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor von Nakanishi, Yoshito, Akiyama, Nukinori, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Sase, Hitoshi, Isobe, Takehito, Morikami, Kenji, Shindoh, Hidetoshi, Mio, Toshiyuki, Ebiike, Hirosato, Taka, Naoki, Aoki, Yuko, Ishii, Nobuya

Volltext

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1 von MASUBUCHI, Miyako, KAWASAKI, Ken-Ichi, OHTSUKA, Tatsuo, SHIMMA, Nobuo, EBIIKE, Hirosato, IKEDA, Yoshihiko, TSUJII, Shinji, SOGABE, Satoshi, FUJII, Toshihiko, SAKATA, Kiyoaki, SHIRATORI, Yasuhiko, AOKI, Yuko

Volltext

YES1 Is a Targetable Oncogene in Cancers Harboring YES1 Gene Amplification von Hamanaka, Natsuki, Nakanishi, Yoshito, Mizuno, Takakazu, Horiguchi-Takei, Kana, Akiyama, Nukinori, Tanimura, Hiromi, Hasegawa, Masami, Satoh, Yasuko, Tachibana, Yukako, Fujii, Toshihiko, Sakata, Kiyoaki, Ogasawara, Kiyomoto, Ebiike, Hirosato, Koyano, Hiroshi, Sato, Haruhiko, Ishii, Nobuya, Mio, Toshiyuki

Volltext

Neuroimaging of histamine H1‐receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second‐generation antihistamine, and (+)‐ch... von Tagawa, Masaaki, Kano, Michiko, Okamura, Nobuyuki, Higuchi, Makoto, Matsuda, Michiaki, Mizuki, Yasuyuki, Arai, Hiroyuki, Iwata, Ren, Fujii, Toshihiko, Komemushi, Sadao, Ido, Tatsuo, Itoh, Masatoshi, Sasaki, Hidetada, Watanabe, Takehiko, Yanai, Kazuhiko

Volltext

Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes von Toide, Kenji, Terauchi, Yoshiaki, Fujii, Toshihiko, Yamazaki, Hiroshi, Kamataki, Tetsuya

Volltext

cDNA Cloning and Expression of a Novel Cytochrome P450 (CYP4F12) from Human Small Intestine von Hashizume, Takanori, Imaoka, Susumu, Hiroi, Toyoko, Terauchi, Yoshiaki, Fujii, Toshihiko, Miyazaki, Hisashi, Kamataki, Tetsuya, Funae, Yoshihiko

Volltext

Acquired JHDM1D-BRAF Fusion Confers Resistance to FGFR Inhibition in FGFR2 -Amplified Gastric Cancer von Sase, Hitoshi, Nakanishi, Yoshito, Aida, Satoshi, Horiguchi-Takei, Kana, Akiyama, Nukinori, Fujii, Toshihiko, Sakata, Kiyoaki, Mio, Toshiyuki, Aoki, Masahiro, Ishii, Nobuya

Volltext

MITF suppression by CH5552074 inhibits cell growth in melanoma cells von Aida, Satoshi, Sonobe, Yukiko, Yuhki, Munehiro, Sakata, Kiyoaki, Fujii, Toshihiko, Sakamoto, Hiroshi, Mizuno, Takakazu

Volltext

The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations von TANAKA, Hiroshi, YOSHIDA, Miyuki, YOSHIMURA, Yasushi, YAMAZAKI, Toshikazu, ISHII, Nobuya, KONDOH, Osamu, AOKI, Yuko, TANIMURA, Hiromi, FUJII, Toshihiko, SAKATA, Kiyoaki, TACHIBANA, Yukako, OHWADA, Jun, EBIIKE, Hirosato, KURAMOTO, Shino, MORITA, Keiichi

Volltext

Differential cognitive effects of ebastine and (+)‐chlorpheniramine in healthy subjects: Correlation between cognitive impairment and plasma drug concentration von Tagawa, Masaaki, Kano, Michiko, Okamura, Nobuyuki, Higuchi, Makoto, Matsuda, Michiaki, Mizuki, Yasuyuki, Arai, Hiroyuki, Fujii, Toshihiko, Komemushi, Sadao, Itoh, Masatoshi, Sasaki, Hidetada, Watanabe, Takehiko, Yanai, Kazuhiko

Volltext