Structural and mechanistic bases for a potent HIV-1 capsid inhibitor von Bester, Stephanie M., Wei, Guochao, Zhao, Haiyan, Adu-Ampratwum, Daniel, Iqbal, Naseer, Courouble, Valentine V., Francis, Ashwanth C., Annamalai, Arun S., Singh, Parmit K., Shkriabai, Nikoloz, Van Blerkom, Peter, Morrison, James, Poeschla, Eric M., Engelman, Alan N., Melikyan, Gregory B., Griffin, Patrick R., Fuchs, James R., Asturias, Francisco J., Kvaratskhelia, Mamuka

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A new class of multimerization selective inhibitors of HIV-1 integrase von Sharma, Amit, Slaughter, Alison, Jena, Nivedita, Feng, Lei, Kessl, Jacques J, Fadel, Hind J, Malani, Nirav, Male, Frances, Wu, Li, Poeschla, Eric, Bushman, Frederic D, Fuchs, James R, Kvaratskhelia, Mamuka

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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation von Jurado, Kellie A., Wang, Hao, Slaughter, Alison, Feng, Lei, Kessl, Jacques J., Koh, Yasuhiro, Wang, Weifeng, Ballandras-Colas, Allison, Patel, Pratiq A., Fuchs, James R., Kvaratskhelia, Mamuka, Engelman, Alan

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Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner von MACE, Thomas A, AMEEN, Zeenath, BLOOMSTON, Mark, LESINSKI, Gregory B, COLLINS, Amy, WOJCIK, Sylwia, MAIR, Markus, YOUNG, Gregory S, FUCHS, James R, EUBANK, Tim D, FRANKEL, Wendy L, BEKAII-SAAB, Tanios

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STarFish: A Stacked Ensemble Target Fishing Approach and its Application to Natural Products von Cockroft, Nicholas T, Cheng, Xiaolin, Fuchs, James R

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HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis von Kessl, Jacques J., Kutluay, Sebla B., Townsend, Dana, Rebensburg, Stephanie, Slaughter, Alison, Larue, Ross C., Shkriabai, Nikoloz, Bakouche, Nordine, Fuchs, James R., Bieniasz, Paul D., Kvaratskhelia, Mamuka

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Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation von Fontana, Juan, Jurado, Kellie A, Cheng, Naiqian, Ly, Ngoc L, Fuchs, James R, Gorelick, Robert J, Engelman, Alan N, Steven, Alasdair C

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Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer von Mize, Brittney K, Salvi, Amrita, Ren, Yulin, Burdette, Joanna E, Fuchs, James R

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Efficacy of quorum sensing and growth inhibitors alone and in combination against avian pathogenic Escherichia coli infection in chickens von Helmy, Yosra A., Kathayat, Dipak, Closs, Gary, Galgozy, Katie, Fuchs, James R., Rajashekara, Gireesh

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors von Kessl, Jacques J., Jena, Nivedita, Koh, Yasuhiro, Taskent-Sezgin, Humeyra, Slaughter, Alison, Feng, Lei, de Silva, Suresh, Wu, Li, Le Grice, Stuart F.J., Engelman, Alan, Fuchs, James R., Kvaratskhelia, Mamuka

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Rocaglamide, silvestrol and structurally related bioactive compounds from Aglaia species von Pan, Li, Woodard, John L, Lucas, David M, Fuchs, James R, Douglas Kinghorn, A

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Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir von Bester, Stephanie M, Adu-Ampratwum, Daniel, Annamalai, Arun S, Wei, Guochao, Briganti, Lorenzo, Murphy, Bridget C, Haney, Reed, Fuchs, James R, Kvaratskhelia, Mamuka

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Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines von Bill, Matthew A, Nicholas, Courtney, Mace, Thomas A, Etter, Jonathan P, Li, Chenglong, Schwartz, Eric B, Fuchs, James R, Young, Gregory S, Lin, Li, Lin, Jiayuh, He, Lei, Phelps, Mitch, Li, Pui-Kai, Lesinski, Gregory B

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Anti-tumor effects of the eIF4A inhibitor didesmethylrocaglamide and its derivatives in human and canine osteosarcomas von Oblinger, Janet L., Wang, Jack, Wetherell, Georgia D., Agarwal, Garima, Wilson, Tyler A., Benson, Nicole R., Fenger, Joelle M., Fuchs, James R., Kinghorn, A. Douglas, Chang, Long-Sheng

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Site-Selective C–H Functionalization of (Hetero)Arenes via Transient, Non-symmetric Iodanes von Fosu, Stacy C., Hambira, Chido M., Chen, Andrew D., Fuchs, James R., Nagib, David A.

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Discovery of Anticancer Agents of Diverse Natural Origin von Aldrich, Leslie N, Burdette, Joanna E, Carcache de Blanco, Esperanza, Coss, Christopher C, Eustaquio, Alessandra S, Fuchs, James R, Kinghorn, A. Douglas, MacFarlane, Amanda, Mize, Brittney K, Oberlies, Nicholas H, Orjala, Jimmy, Pearce, Cedric J, Phelps, Mitch A, Rakotondraibe, Liva Harinantenaina, Ren, Yulin, Soejarto, Djaja Doel, Stockwell, Brent R, Yalowich, Jack C, Zhang, Xiaoli

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Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation von Tokarski, Robert J., Sharpe, Chia M., Huntsman, Andrew C., Mize, Brittney K., Ayinde, Oluwatosin R., Stahl, Emily H., Lerma, James R., Reed, Andrew, Carmichael, Bridget, Muthusamy, Natarajan, Byrd, John C., Fuchs, James R.

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Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing von Hoyte, Ashley C., Jamin, Augusta V., Koneru, Pratibha C., Kobe, Matthew J., Larue, Ross C., Fuchs, James R., Engelman, Alan N., Kvaratskhelia, Mamuka

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TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism von Fadel, Hind J, Morrison, James H, Saenz, Dyana T, Fuchs, James R, Kvaratskhelia, Mamuka, Ekker, Stephen C, Poeschla, Eric M

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The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors von Feng, Lei, Sharma, Amit, Slaughter, Alison, Jena, Nivedita, Koh, Yasuhiro, Shkriabai, Nikolozi, Larue, Ross C., Patel, Pratiq A., Mitsuya, Hiroaki, Kessl, Jacques J., Engelman, Alan, Fuchs, James R., Kvaratskhelia, Mamuka

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