Recombinant human hyaluronidase (rHuPH20): an enabling platform for subcutaneous drug and fluid administration von Frost, Gregory I

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Tumor-associated hyaluronan limits efficacy of monoclonal antibody therapy von Singha, Netai C, Nekoroski, Tara, Zhao, Chunmei, Symons, Rebecca, Jiang, Ping, Frost, Gregory I, Huang, Zhongdong, Shepard, H Michael

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Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase von DuFort, Christopher C., DelGiorno, Kathleen E., Carlson, Markus A., Osgood, Ryan J., Zhao, Chunmei, Huang, Zhongdong, Thompson, Curtis B., Connor, Robert J., Thanos, Christopher D., Scott Brockenbrough, J., Provenzano, Paolo P., Frost, Gregory I., Michael Shepard, H., Hingorani, Sunil R.

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Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models von Thompson, Curtis B, Shepard, H Michael, O'Connor, Patrick M, Kadhim, Salam, Jiang, Ping, Osgood, Ryan J, Bookbinder, Louis H, Li, Xiaoming, Sugarman, Barry J, Connor, Robert J, Nadjsombati, Sinisa, Frost, Gregory I

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KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions von Marella, Mathieu, Jadin, Laurence, Keller, Gilbert A, Sugarman, Barry J, Frost, Gregory I, Shepard, H Michael

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Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment von Singha, Netai C., Zhao, Chunmei, Kultti, Anne, Zimmerman, Susan, Osgood, Ryan J., Symons, Rebecca, Jiang, Ping, Li, Xiaoming, Thompson, Curtis B., Infante, Jeffrey R., Jacobetz, Michael A., Tuveson, David A., Frost, Gregory I., Shepard, H. Michael, Huang, Zhongdong

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Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX? von Jadin, Laurence, Wu, Xiaoli, Ding, Hao, Frost, Gregory I, Onclinx, Cécile, Triggs-Raine, Barbara, Flamion, Bruno

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Therapeutic targeting of hyaluronan in the tumor stroma von Kultti, Anne, Li, Xiaoming, Jiang, Ping, Thompson, Curtis B, Frost, Gregory I, Shepard, H Michael

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Characterization of a Novel Recombinant Hyaluronan Binding Protein for Tissue Hyaluronan Detection von Jadin, Laurence, Huang, Lei, Wei, Ge, Zhao, Qiping, Gelb, Arnold B., Frost, Gregory I., Jiang, Ping, Shepard, H. Michael

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Response to Chauhan et al.: Interstitial Pressure and Vascular Collapse in Pancreas Cancer—Fluids and Solids, Measurement and Meaning von DelGiorno, Kathleen E., Carlson, Markus A., Osgood, Ryan, Provenzano, Paolo P., Brockenbough, J. Scott, Thompson, Curtis B., Shepard, H. Michael, Frost, Gregory I., Potter, John D., Hingorani, Sunil R.

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer von Jacobetz, Michael A, Chan, Derek S, Neesse, Albrecht, Bapiro, Tashinga E, Cook, Natalie, Frese, Kristopher K, Feig, Christine, Nakagawa, Tomoaki, Caldwell, Meredith E, Zecchini, Heather I, Lolkema, Martijn P, Jiang, Ping, Kultti, Anne, Thompson, Curtis B, Maneval, Daniel C, Jodrell, Duncan I, Frost, Gregory I, Shepard, H M, Skepper, Jeremy N, Tuveson, David A

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Hyaluronidase reduces human breast cancer xenografts in SCID mice von Shuster, Svetlana, Frost, Gregory I., Csoka, Antonei B., Formby, Bent, Stern, Robert

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Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of infl... von Huang, Zhongdong, Zhao, Chunmei, Chen, Yanling, Cowell, Jessica A, Wei, Ge, Kultti, Anne, Huang, Lei, Thompson, Curtis B, Rosengren, Sanna, Frost, Gregory I, Shepard, H Michael

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A comprehensive model of hyaluronan turnover in the mouse von Jadin, Laurence, Bookbinder, Louis H., Frost, Gregory I.

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Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration von Rosengren, Sanna, Dychter, Samuel S., Printz, Marie A., Huang, Lei, Schiff, Richard I., Schwarz, Hans-Peter, McVey, John K., Drake, Fred H., Maneval, Dan C., Kennard, Don A., Frost, Gregory I., Sugarman, Barry J., Muchmore, Douglas B.

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Effective Targeting of the Tumor Microenvironment for Cancer Therapy von PING JIANG, XIAOMING LI, THOMPSON, Curtis B, ZHONGDONG HUANG, ARAIZA, Flavio, OSGOOD, Ryan, GE WEI, FELDMANN, Marc, FROST, Gregory I, SHEPARD, H. Michael

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A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema von Nekoroski, Tara, Paladini, Rudolph D., Sauder, Daniel N., Frost, Gregory I., Keller, Gilbert-A.

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Mutations in the Catalytic Domain of Human Matrix Metalloproteinase-1 (MMP-1) That Allow for Regulated Activity through the Use of Ca2 von Paladini, Rudolph D., Wei, Ge, Kundu, Anirban, Zhao, Qiping, Bookbinder, Louis H., Keller, Gilbert A., Shepard, H.Michael, Frost, Gregory I.

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Accelerated pharmacokinetics and glucodynamics of prandial insulins injected with recombinant human hyaluronidase von Vaughn, Daniel E, Yocum, Richard C, Muchmore, Douglas B, Sugarman, Barry J, Vick, Andrew M, Bilinsky, Igor P, Frost, Gregory I

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Erratum to: Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration von Rosengren, Sanna, Dychter, Samuel S., Printz, Marie A., Huang, Lei, Schiff, Richard I., Schwarz, Hans-Peter, McVey, John K., Drake, Fred H., Maneval, Dan C., Kennard, Don A., Frost, Gregory I., Sugarman, Barry J., Muchmore, Douglas B.

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