Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker von Poblocka, Marta, Bassey, Akang Leonard, Smith, Victoria M., Falcicchio, Marta, Manso, Ana Sousa, Althubiti, Mohammad, Sheng, XiaoBo, Kyle, Andrew, Barber, Ruth, Frigerio, Mark, Macip, Salvador

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Bridging Disulfides for Stable and Defined Antibody Drug Conjugates von Badescu, George, Bryant, Penny, Bird, Matthew, Henseleit, Korinna, Swierkosz, Julia, Parekh, Vimal, Tommasi, Rita, Pawlisz, Estera, Jurlewicz, Kosma, Farys, Monika, Camper, Nicolas, Sheng, XiaoBo, Fisher, Martin, Grygorash, Ruslan, Kyle, Andrew, Abhilash, Amrita, Frigerio, Mark, Edwards, Jeff, Godwin, Antony

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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion von Golding, Sarah E, Rosenberg, Elizabeth, Valerie, Nicholas, Hussaini, Isa, Frigerio, Mark, Cockcroft, Xiaoling F, Chong, Wei Yee, Hummersone, Marc, Rigoreau, Laurent, Menear, Keith A, O'Connor, Mark J, Povirk, Lawrence F, van Meter, Timothy, Valerie, Kristoffer

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Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4 von Griffiths, Katherine, Binder, Uli, McDowell, William, Tommasi, Rita, Frigerio, Mark, Darby, William G, Hosking, Chris G, Renaud, Lionel, Machacek, Matthias, Lloyd, Peter, Skerra, Arne, Foley, Michael

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Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance von Evans, Nick, Grygorash, Ruslan, Williams, Paul, Kyle, Andrew, Kantner, Terrence, Pathak, Ravindra, Sheng, XiaoBo, Simoes, Fabio, Makwana, Hiteshri, Resende, Ricardo, de Juan, Elena, Jenkins, Alan, Morris, David, Michelet, Aurelie, Jewitt, Frances, Rudge, Felicity, Camper, Nicolas, Manin, Anaïs, McDowell, William, Pabst, Martin, Godwin, Antony, Frigerio, Mark, Bird, Matthew

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The chemistry and biology of the bryostatin antitumour macrolides von Hale, Karl J, Hummersone, Marc G, Manaviazar, Soraya, Frigerio, Mark

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Enantioselective Formal Total Synthesis of the Antitumor Macrolide Bryostatin 7 von Manaviazar, Soraya, Frigerio, Mark, Bhatia, Gurpreet S, Hummersone, Marc G, Aliev, Abil E, Hale, Karl J

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Bridged Cysteine Conjugations von Bird, Matthew, Nunes, Joao, Frigerio, Mark

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In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab–MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios von Bryant, Penny, Pabst, Martin, Badescu, George, Bird, Matthew, McDowell, William, Jamieson, Estera, Swierkosz, Julia, Jurlewicz, Kosma, Tommasi, Rita, Henseleit, Korinna, Sheng, XiaoBo, Camper, Nicolas, Manin, Anais, Kozakowska, Katarzyna, Peciak, Karolina, Laurine, Emmanuelle, Grygorash, Ruslan, Kyle, Andrew, Morris, David, Parekh, Vimal, Abhilash, Amrita, Choi, Ji-won, Edwards, Jeff, Frigerio, Mark, Baker, Matthew P, Godwin, Antony

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Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates von Pabst, Martin, McDowell, William, Manin, Anaïs, Kyle, Andrew, Camper, Nicolas, De Juan, Elena, Parekh, Vimal, Rudge, Felicity, Makwana, Hiteshri, Kantner, Terrence, Parekh, Hemal, Michelet, Aurelie, Sheng, XiaoBo, Popa, Gina, Tucker, Carolyn, Khayrzad, Farzad, Pollard, Derek, Kozakowska, Katarzyna, Resende, Ricardo, Jenkins, Alan, Simoes, Fabio, Morris, Dave, Williams, Paul, Badescu, George, Baker, Matthew P., Bird, Matthew, Frigerio, Mark, Godwin, Antony

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A Short Synthetic Pathway to a Fully-Functionalized Southern Hemisphere of the Antitumor Macrolide Bryostatin 1 von Hale, Karl J, Frigerio, Mark, Manaviazar, Soraya

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1-Substituted (Dibenzo[ b,d ]thiophen-4-yl)-2-morpholino-4 H -chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity von Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J., Frigerio, Mark, Golding, Bernard T., Hardcastle, Ian R., Hummersone, Marc G., Menear, Keith A., Newell, David R., Richardson, Caroline J., Shea, K., Smith, Graeme C. M., Thommes, Pia, Ting, Attilla, Griffin, Roger J.

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1‑Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino‑4H‑chromen-4-ones Endowed with Dual DNA-PK/PI3‑K Inhibitory Activity von Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Menear, Keith A, Newell, David R, Richardson, Caroline J, Shea, K, Smith, Graeme C. M, Thommes, Pia, Ting, Attilla, Griffin, Roger J

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Abstract 1217: Preclinical evaluation of a next-generation, EGFR targeting ADC that promotes regression in KRAS or BRAF mutant tumors von Huang, Lei, Veneziale, Bob, Frigerio, Mark, Badescu, George, Li, Xiaoming, Zhao, Qiping, Bahn, Jesse, Souratha, Jennifer, Osgood, Ryan, Zhao, Chunmei, Phan, Kim, Cowell, Jessica, Rosengren, Sanna, Parise, Jason, Pabst, Martin, Bird, Mathew, McDowell, William, Wei, Gina, Thompson, Curtis, Godwin, Antony, Shepard, Michael, Thanos, Christopher

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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell linesPart 43 in the series 'Antitumour Imidazotetra... von Cousin, David, Zhang, Jihong, Hummersone, Marc G, Matthews, Charles S, Frigerio, Mark, Bradshaw, Tracey D, Stevens, Malcolm F. G

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Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure−Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and... von Hollick, Jonathan J, Rigoreau, Laurent J. M, Cano-Soumillac, Celine, Cockcroft, Xiaoling, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Guiard, Sophie, Hardcastle, Ian R, Hickson, Ian, Hummersone, Marc G, Menear, Keith A, Martin, Niall M. B, Matthews, Ian, Newell, David R, Ord, Rachel, Richardson, Caroline J, Smith, Graeme C. M, Griffin, Roger J

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On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts von Iachettini, Sara, Stevens, Malcolm Fg, Frigerio, Mark, Hummersone, Marc G, Hutchinson, Ian, Garner, Thomas P, Searle, Mark S, Wilson, David W, Munde, Manoj, Nanjunda, Rupesh, D'Angelo, Carmen, Zizza, Pasquale, Rizzo, Angela, Cingolani, Chiara, De Cicco, Federica, Porru, Manuela, D'Incalci, Maurizio, Leonetti, Carlo, Biroccio, Annamaria, Salvati, Erica

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Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines von Cousin, David, Zhang, Jihong, Hummersone, Marc G., Matthews, Charles S., Frigerio, Mark, Bradshaw, Tracey D., Stevens, Malcolm F. G.

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DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype von Cano, Céline, Barbeau, Olivier R, Bailey, Christine, Cockcroft, Xiao-Ling, Curtin, Nicola J, Duggan, Heather, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Knights, Charlotte, Menear, Keith A, Newell, David R, Richardson, Caroline J, Smith, Graeme C. M, Spittle, Ben, Griffin, Roger J

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Conjugados y reactivos de conjugación von GODWIN, Antony, FRIGERIO, Mark

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