Phase II Study of Ganitumab, a Fully Human Anti–Type-1 Insulin-Like Growth Factor Receptor Antibody, in Patients With Metastatic Ewing Family Tumors or Desmoplastic Small Round Cel... von TAP, William D, DEMETRI, George, LEITCH, Ian, BADOLA, Sunita, SUNG CHANG, MIN ZHU, TOLCHER, Anthony, BARNETTE, Phillip, DESAI, Jayesh, KAVAN, Petr, TOZER, Richard, BENEDETTO, Pasquale W, FRIBERG, Gregory, HONGJIE DENG, MCCAFFERY, Ian

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A phase 1, first-in-human study of AMG 900, an orally administered pan-Aurora kinase inhibitor, in adult patients with advanced solid tumors von Carducci, Michael, Shaheen, Montaser, Markman, Ben, Hurvitz, Sara, Mahadevan, Daruka, Kotasek, Dusan, Goodman, Oscar B., Rasmussen, Erik, Chow, Vincent, Juan, Gloria, Friberg, Gregory R., Gamelin, Erick, Vogl, Florian D., Desai, Jayesh

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Phase II Trial of Bevacizumab Plus Gemcitabine in Patients With Advanced Pancreatic Cancer von KINDLER, Hedy L, FRIBERG, Gregory, VOKES, Everett E, SINGH, Deepti A, LOCKER, Gershon, NATTAM, Sreenivasa, KOZLOFF, Mark, TABER, David A, KARRISON, Theodore, DACHMAN, Abraham, STADLER, Walter M

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Sotorasib for Lung Cancers with KRAS p.G12C Mutation von Skoulidis, Ferdinandos, Li, Bob T, Dy, Grace K, Price, Timothy J, Falchook, Gerald S, Wolf, Jürgen, Italiano, Antoine, Schuler, Martin, Borghaei, Hossein, Barlesi, Fabrice, Kato, Terufumi, Curioni-Fontecedro, Alessandra, Sacher, Adrian, Spira, Alexander, Ramalingam, Suresh S, Takahashi, Toshiaki, Besse, Benjamin, Anderson, Abraham, Ang, Agnes, Tran, Qui, Mather, Omar, Henary, Haby, Ngarmchamnanrith, Gataree, Friberg, Gregory, Velcheti, Vamsidhar, Govindan, Ramaswamy

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KRAS(G12C) Inhibition with Sotorasib in Advanced Solid Tumors von Hong, David S., Fakih, Marwan G., Strickler, John H., Desai, Jayesh, Durm, Gregory A., Shapiro, Geoffrey I., Falchook, Gerald S., Price, Timothy J., Sacher, Adrian, Denlinger, Crystal S., Bang, Yung-Jue, Dy, Grace K., Krauss, John C., Kuboki, Yasutoshi, Kuo, James C., Coveler, Andrew L., Park, Keunchil, Kim, Tae Won, Barlesi, Fabrice, Munster, Pamela N., Ramalingam, Suresh S., Burns, Timothy F., Meric-Bernstam, Funda, Henary, Haby, Ngang, Jude, Ngarmchamnanrith, Gataree, Kim, June, Houk, Brett E., Canon, Jude, Lipford, J. Russell, Friberg, Gregory, Lito, Piro, Govindan, Ramaswamy, Li, Bob T.

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Abstract 439: Detection of aurora kinase A (AURKA) focal amplification in plasma samples of patients with recurrent ovarian cancer von Juan, Gloria, Paweletz, Katherine, Anderson, Abraham, Gamelin, Erick, Friberg, Gregory, Loberg, Robert, Vogl, Florian

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AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models von Bush, Tammy L, Payton, Marc, Heller, Scott, Chung, Grace, Hanestad, Kelly, Rottman, James B, Loberg, Robert, Friberg, Gregory, Kendall, Richard L, Saffran, Douglas, Radinsky, Robert

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KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors von Hong, David S, Fakih, Marwan G, Strickler, John H, Desai, Jayesh, Durm, Gregory A, Shapiro, Geoffrey I, Falchook, Gerald S, Price, Timothy J, Sacher, Adrian, Denlinger, Crystal S, Bang, Yung-Jue, Dy, Grace K, Krauss, John C, Kuboki, Yasutoshi, Kuo, James C, Coveler, Andrew L, Park, Keunchil, Kim, Tae Won, Barlesi, Fabrice, Munster, Pamela N, Ramalingam, Suresh S, Burns, Timothy F, Meric-Bernstam, Funda, Henary, Haby, Ngang, Jude, Ngarmchamnanrith, Gataree, Kim, June, Houk, Brett E, Canon, Jude, Lipford, J. Russell, Friberg, Gregory, Lito, Piro, Govindan, Ramaswamy, Li, Bob T

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A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors von Dowlati, Afshin, Vlahovic, Gordana, Natale, Ronald B, Rasmussen, Erik, Singh, Indrajeet, Hwang, Yuying C, Rossi, John, Bass, Michael B, Friberg, Gregory, Pickett, Cheryl A

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A phase 1 study of AMG 900, an orally administered pan‐aurora kinase inhibitor, in adult patients with acute myeloid leukemia von Kantarjian, Hagop M., Schuster, Michael W., Jain, Nitin, Advani, Anjali, Jabbour, Elias, Gamelin, Erick, Rasmussen, Erik, Juan, Gloria, Anderson, Abraham, Chow, Vincent F., Friberg, Gregory, Vogl, Florian D., Sekeres, Mikkael A.

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KRAS G12C Inhibition with Sotorasib in Advanced Solid Tumors von Hong, David S, Fakih, Marwan G, Strickler, John H, Desai, Jayesh, Durm, Gregory A, Shapiro, Geoffrey I, Falchook, Gerald S, Price, Timothy J, Sacher, Adrian, Denlinger, Crystal S, Bang, Yung-Jue, Dy, Grace K, Krauss, John C, Kuboki, Yasutoshi, Kuo, James C, Coveler, Andrew L, Park, Keunchil, Kim, Tae Won, Barlesi, Fabrice, Munster, Pamela N, Ramalingam, Suresh S, Burns, Timothy F, Meric-Bernstam, Funda, Henary, Haby, Ngang, Jude, Ngarmchamnanrith, Gataree, Kim, June, Houk, Brett E, Canon, Jude, Lipford, J Russell, Friberg, Gregory, Lito, Piro, Govindan, Ramaswamy, Li, Bob T

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Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: A trial of the Chicago, PMH, and California Ph... von Nimeiri, Halla S, Oza, Amit M, Morgan, Robert J, Friberg, Gregory, Kasza, Kristen, Faoro, Leonardo, Salgia, Ravi, Stadler, Walter M, Vokes, Everett E, Fleming, Gini F

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Abstract CT045: Phase 1, open-label, first-in-human study of AMG 900, an orally administered pan-aurora kinase inhibitor, in adult patients (pts) with advanced solid tumors von Shaheen, Montasser, Markman, Ben, Carducci, Michael, Hurvitz, Sara, Mahadevan, Daruka, Kotasek, Dusan, Goodman, Oscar, Gamelin, Erick, Chow, Vincent, Juan, Gloria, Rasmussen, Erik, Friberg, Gregory R., Vogl, Florian D., Desai, Jayesh

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Abstract 3008: Preclinical characterization of AMG 900, a pan-aurora kinase inhibitor, alone and in combination with taxanes in ovarian cancer von Kalous, Ondrej, Conklin, Dylan, Manivong, Kanthinh, Wayne, William, Hanestad, Kelly, Canon, Jude, Loberg, Robert, Friberg, Gregory, Gamelin, Erick, Vogl, Florian D., Juan, Gloria, Coxon, Angela, Slamon, Dennis, Finn, Richard, Payton, Marc

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Safety and Pharmacokinetics of Ganitumab (AMG 479) Combined with Sorafenib, Panitumumab, Erlotinib, or Gemcitabine in Patients with Advanced Solid Tumors von ROSEN, Lee S, PUZANOV, Igor, MITA, Alain C, MITA, Monica M, MULAY, Marilyn, SHUBHAKAR, Poornima, MIN ZHU, SARANTOPOULOS, John, FRIBERG, Gregory, CHAN, Emily, HWANG, Yuying C, HONGJIE DENG, GILBERT, Jill, MAHALINGAM, Devalingam, MCCAFFERY, Ian, MICHAEL, Shaunita A

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A first-in-human study of AMG 780, an angiopoietin-1 and -2 (ANG1/2) inhibitor, in patients (pts) with advanced solid tumors von Dowlati, Afshin, Vlahovic, Gordana, Natale, Ronald B., Rasmussen, Erik, Singh, Indrajeet, Hwang, Yuying C., Rossi, John, Bass, Michael B., Friberg, Gregory R., Pickett-Gies, Cheryl Ann

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Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation von Keating, Susan M., Taylor, D. Lansing, Plant, Anne L., Litwack, E. David, Kuhn, Peter, Greenspan, Emily J., Hartshorn, Christopher M., Sigman, Caroline C., Kelloff, Gary J., Chang, David D., Friberg, Gregory, Lee, Jerry S. H., Kuida, Keisuke

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First-In-Human Study Of AMG 319, a Highly Selective, Small Molecule Inhibitor Of PI3Kδ, In Adult Patients With Relapsed Or Refractory Lymphoid Malignancies von Lanasa, Mark C., Glenn, Martha, Mato, Anthony R., Allgood, Sallie D., Wong, Susan, Amore, Benny, Means, Gary, Stevens, Erin, Yan, Chris, Friberg, Gregory, Goy, Andre

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Evaluation of pharmacokinetic (PK) drug-drug interactions (DDI) between trebananib (AMG 386) and paclitaxel (PTX) in patients (pts) with advanced solid tumors von Diamond, Jennifer Robinson, Agarwal, Neeraj, Bowles, Daniel W., Lam, Elaine Tat, Werner, Theresa Louise, Wu, Benjamin, Rasmussen, Erik, Gamelin, Erick, Soto, Felipe, Friberg, Gregory R., Sun, Yu-Nien, Sharma, Sunil

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AMG 900, a Potent and Highly Selective Aurora Kinase Inhibitor Shows Promising Preclinical Activity Against Acute Myeloid Leukemia Cell Lines In Vitro and In Vivo von Cheung, Kam, Juan, Gloria, Wayne, William, Hanestad, Kelly, Keegan, Kathleen, Huard, Justin, McElroy, Patricia, Stanton, Mary K, Bush, Tammy L, Kendall, Richard L, Radinsky, Robert, Abella, Steve, Pieslor, Peter C, Friberg, Gregory, Coxon, Angela, Gamelin, Erick, Payton, Marc

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