Antibody therapies in CNS diseases von Freskgård, Per-Ola, Urich, Eduard

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Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle von Niewoehner, Jens, Bohrmann, Bernd, Collin, Ludovic, Urich, Eduard, Sade, Hadassah, Maier, Peter, Rueger, Petra, Stracke, Jan Olaf, Lau, Wilma, Tissot, Alain C, Loetscher, Hansruedi, Ghosh, Anirvan, Freskgård, Per-Ola

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Region-specific permeability of the blood–brain barrier upon pericyte loss von Villaseñor, Roberto, Kuennecke, Basil, Ozmen, Laurence, Ammann, Michelle, Kugler, Christof, Grüninger, Fiona, Loetscher, Hansruedi, Freskgård, Per-Ola, Collin, Ludovic

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Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models von Urich, Eduard, Lazic, Stanley E, Molnos, Juliette, Wells, Isabelle, Freskgård, Per-Ola

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A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding von Sade, Hadassah, Baumgartner, Claudia, Hugenmatter, Adrian, Moessner, Ekkehard, Freskgård, Per-Ola, Niewoehner, Jens

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Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier von Urich, Eduard, Patsch, Christoph, Aigner, Stefan, Graf, Martin, Iacone, Roberto, Freskgård, Per-Ola

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Brain Shuttle Neprilysin reduces central Amyloid-β levels von Campos, Christopher R, Kemble, Alicia M, Niewoehner, Jens, Freskgård, Per-Ola, Urich, Eduard

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Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans von Grimm, Hans Peter, Schumacher, Vanessa, Schäfer, Martin, Imhof-Jung, Sabine, Freskgård, Per-Ola, Brady, Kevin, Hofmann, Carsten, Rüger, Petra, Schlothauer, Tilman, Göpfert, Ulrich, Hartl, Maximilian, Rottach, Sylvia, Zwick, Adrian, Seger, Shanon, Neff, Rachel, Niewoehner, Jens, Janssen, Niels

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Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct von Gehrlein, Alexandra, Udayar, Vinod, Anastasi, Nadia, Morella, Martino L., Ruf, Iris, Brugger, Doris, von der Mark, Sophia, Thoma, Ralf, Rufer, Arne, Heer, Dominik, Pfahler, Nina, Jochner, Anton, Niewoehner, Jens, Wolf, Luise, Fueth, Matthias, Ebeling, Martin, Villaseñor, Roberto, Zhu, Yanping, Deen, Matthew C., Shan, Xiaoyang, Ehsaei, Zahra, Taylor, Verdon, Sidransky, Ellen, Vocadlo, David J., Freskgård, Per-Ola, Jagasia, Ravi

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Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier von Villaseñor, Roberto, Ozmen, Laurence, Messaddeq, Nadia, Grüninger, Fiona, Loetscher, Hansruedi, Keller, Annika, Betsholtz, Christer, Freskgård, Per-Ola, Collin, Ludovic

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Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode von Weber, Felix, Bohrmann, Bernd, Niewoehner, Jens, Fischer, Jens A.A., Rueger, Petra, Tiefenthaler, Georg, Moelleken, Joerg, Bujotzek, Alexander, Brady, Kevin, Singer, Thomas, Ebeling, Martin, Iglesias, Antonio, Freskgård, Per-Ola

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MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non‐clinical species and Alzheimer's disease patients von Lloyd, Christopher, Freskgård, Per‐Ola, Newton, Philip, Lowne, David, Nickson, Adrian, Bogstedt, Anna, Eketjäll, Susanna, Höglund, Kina, Gustavsson, Susanne, Welsh, Fraser, Chessell, Tharani, McFarlane, Mary, Bhat, Ratan V., Turner, Richard, Perkinton, Michael S., Santisteban Valencia, Zulma, Lindqvist, Eva, Pomfret, Michael, Dudley, Amanda D., Vaughan, Tristan J., Groves, Maria T., Natanegara, Fanni, Feng, Yingdong, Sims, John R., Proctor, Nicholas Kyle, Dage, Jeffrey L., Shering, Craig, Tan, Keith, Ostenfeld, Thor, Billinton, Andy, Chessell, Iain P.

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Cargo Delivery into the Brain by in vivo identified Transport Peptides von Urich, Eduard, Schmucki, Roland, Ruderisch, Nadine, Kitas, Eric, Certa, Ulrich, Jacobsen, Helmut, Schweitzer, Christophe, Bergadano, Alessandra, Ebeling, Martin, Loetscher, Hansruedi, Freskgård, Per-Ola

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Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport von Ruderisch, Nadine, Schlatter, Daniel, Kuglstatter, Andreas, Guba, Wolfgang, Huber, Sylwia, Cusulin, Carlo, Benz, Jörg, Rufer, Arne Christian, Hoernschemeyer, Joerg, Schweitzer, Christophe, Bülau, Tina, Gärtner, Achim, Hoffmann, Eike, Niewoehner, Jens, Patsch, Christoph, Baumann, Karlheinz, Loetscher, Hansruedi, Kitas, Eric, Freskgård, Per-Ola

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Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells von Patsch, Christoph, Challet-Meylan, Ludivine, Thoma, Eva C., Urich, Eduard, Heckel, Tobias, O’Sullivan, John F., Grainger, Stephanie J., Kapp, Friedrich G., Sun, Lin, Christensen, Klaus, Xia, Yulei, Florido, Mary H. C., He, Wei, Pan, Wei, Prummer, Michael, Warren, Curtis R., Jakob-Roetne, Roland, Certa, Ulrich, Jagasia, Ravi, Freskgård, Per-Ola, Adatto, Isaac, Kling, Dorothee, Huang, Paul, Zon, Leonard I., Chaikof, Elliot L., Gerszten, Robert E., Graf, Martin, Iacone, Roberto, Cowan, Chad A.

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Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β von HENDERSON, Simon J, ANDERSSON, Christin, FRESKGARD, Per Ola, JERMUTUS, Lutz, BURRELL, Matthew, FOWLER, Susan B, WEBSTER, Carl I, NARWAL, Rajesh, JANSON, Juliette, GOLDSCHMIDT, Tom J, APPELKVIST, Paulina, BOGSTEDT, Anna, ANN-CHARLOTT, Steffen, HAUPTS, Ulrich, TEBBE, Jan

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First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils von Weber, Felix, Breustedt, Daniel, Schlicht, Sonja, Meyer, Claas A., Niewoehner, Jens, Ebeling, Martin, Freskgard, Per-Ola, Bruenker, Peter, Singer, Thomas, Reth, Michael, Iglesias, Antonio

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Isomerase and Chaperone Activity of Prolyl Isomerase in the Folding of Carbonic Anhydrase von Freskgård, Per-Ola, Bergenhem, Nils, Jonsson, Bengt-Harald, Svensson, Magdalena, Carlsson, Uno

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Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor von Carlsson, Karin, Freskgård, Per‐Ola, Persson, Egon, Carlsson, Uno, Svensson, Magdalena

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Sequential coagulation factor VIIa domain binding to tissue factor von Österlund, Maria, Persson, Egon, Carlsson, Uno, Freskgård, Per-Ola, Svensson, Magdalena

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