Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors von Aslanoglou, Despoina, Bertera, Suzanne, Sánchez-Soto, Marta, Benjamin Free, R., Lee, Jeongkyung, Zong, Wei, Xue, Xiangning, Shrestha, Shristi, Brissova, Marcela, Logan, Ryan W., Wollheim, Claes B., Trucco, Massimo, Yechoor, Vijay K., Sibley, David R., Bottino, Rita, Freyberg, Zachary

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Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds von Moritz, Amy E., Free, R. Benjamin, Sibley, David R.

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New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion von Farino, Zachary J., Morgenstern, Travis J., Maffei, Antonella, Quick, Matthias, De Solis, Alain J., Wiriyasermkul, Pattama, Freyberg, Robin J., Aslanoglou, Despoina, Sorisio, Denise, Inbar, Benjamin P., Free, R. Benjamin, Donthamsetti, Prashant, Mosharov, Eugene V., Kellendonk, Christoph, Schwartz, Gary J., Sibley, David R., Schmauss, Claudia, Zeltser, Lori M., Moore, Holly, Harris, Paul E., Javitch, Jonathan A., Freyberg, Zachary

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A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity von Sanchez-Soto, Marta, Verma, Ravi Kumar, Willette, Blair K A, Gonye, Elizabeth C, Moore, Annah M, Moritz, Amy E, Boateng, Comfort A, Yano, Hideaki, Free, R Benjamin, Shi, Lei, Sibley, David R

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Development of pyrimidone D1 dopamine receptor positive allosteric modulators von Luderman, Kathryn D., Jain, Prashi, Benjamin Free, R., Conroy, Jennie L., Aubé, Jeffrey, Sibley, David R., Frankowski, Kevin J.

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Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors von Michino, Mayako, Free, R Benjamin, Doyle, Trevor B, Sibley, David R, Shi, Lei

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Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential von Sibley, David R., Luderman, Kathryn D., Free, R. Benjamin, Shi, Lei

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Ligand with Two Modes of Interaction with the Dopamine D2 Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism von Ågren, Richard, Zeberg, Hugo, Stępniewski, Tomasz Maciej, Free, R. Benjamin, Reilly, Sean W, Luedtke, Robert R, Århem, Peter, Ciruela, Francisco, Sibley, David R, Mach, Robert H, Selent, Jana, Nilsson, Johanna, Sahlholm, Kristoffer

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G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation von Sánchez-Soto, Marta, Boldizsar, Noelia M., Schardien, Kayla A., Madaras, Nora S., Willette, Blair K. A., Inbody, Laura R., Dasaro, Christopher, Moritz, Amy E., Drube, Julia, Haider, Raphael S., Free, R. Benjamin, Hoffman, Carsten, Sibley, David R.

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The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors von Verma, Ravi Kumar, Abramyan, Ara M, Michino, Mayako, Free, R Benjamin, Sibley, David R, Javitch, Jonathan A, Lane, J Robert, Shi, Lei

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Advances and challenges in the search for D 2 and D 3 dopamine receptor-selective compounds von Moritz, Amy E, Free, R Benjamin, Sibley, David R

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Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine von Aslanoglou, Despoina, Bertera, Suzanne, Friggeri, Laura, Sánchez-Soto, Marta, Lee, Jeongkyung, Xue, Xiangning, Logan, Ryan W., Lane, J. Robert, Yechoor, Vijay K., McCormick, Peter J., Meiler, Jens, Free, R. Benjamin, Sibley, David R., Bottino, Rita, Freyberg, Zachary

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D1 and D2 Dopamine Receptor Expression Is Regulated by Direct Interaction with the Chaperone Protein Calnexin von Free, R. Benjamin, Hazelwood, Lisa A., Cabrera, David M., Spalding, Heather N., Namkung, Yoon, Rankin, Michele L., Sibley, David R.

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Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor von Chun, Lani S., Vekariya, Rakesh H., Free, R. Benjamin, Li, Yun, Lin, Da-Ting, Su, Ping, Liu, Fang, Namkung, Yoon, Laporte, Stephane A., Moritz, Amy E., Aubé, Jeffrey, Frankowski, Kevin J., Sibley, David R.

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Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor von Free, R. Benjamin, Cuoco, Caroline A., Xie, Bing, Namkung, Yoon, Prabhu, Varun V., Willette, Blair K.A., Day, Marilyn M., Sanchez-Soto, Marta, Lane, J. Robert, Laporte, Stéphane A., Shi, Lei, Allen, Joshua E., Sibley, David R.

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Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Rece... von Kumar, Vivek, Moritz, Amy E, Keck, Thomas M, Bonifazi, Alessandro, Ellenberger, Michael P, Sibley, Christopher D, Free, R. Benjamin, Shi, Lei, Lane, J. Robert, Sibley, David R, Newman, Amy Hauck

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Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist von Moritz, Amy E, Free, R. Benjamin, Weiner, Warren S, Akano, Emmanuel O, Gandhi, Disha, Abramyan, Ara, Keck, Thomas M, Ferrer, Marc, Hu, Xin, Southall, Noel, Steiner, Joseph, Aubé, Jeffrey, Shi, Lei, Frankowski, Kevin J, Sibley, David R

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Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D 3 Dopamine Receptor Agonist von Moritz, Amy E, Free, R Benjamin, Weiner, Warren S, Akano, Emmanuel O, Gandhi, Disha, Abramyan, Ara, Keck, Thomas M, Ferrer, Marc, Hu, Xin, Southall, Noel, Steiner, Joseph, Aubé, Jeffrey, Shi, Lei, Frankowski, Kevin J, Sibley, David R

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D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms von Chun, Lani S, Free, R Benjamin, Doyle, Trevor B, Huang, Xi-Ping, Rankin, Michele L, Sibley, David R

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Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D 3 Rec... von Kumar, Vivek, Moritz, Amy E, Keck, Thomas M, Bonifazi, Alessandro, Ellenberger, Michael P, Sibley, Christopher D, Free, R Benjamin, Shi, Lei, Lane, J Robert, Sibley, David R, Newman, Amy Hauck

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