Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer von Franovic, Aleksandra, Gunaratnam, Lakshman, Smith, Karlene, Robert, Isabelle, Patten, David, Lee, Stephen

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Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations von Li, Gang G, Somwar, Romel, Joseph, James, Smith, Roger S, Hayashi, Takuo, Martin, Leenus, Franovic, Aleksandra, Schairer, Anni, Martin, Eric, Riely, Gregory J, Harris, Jason, Yan, Shunqi, Wei, Ge, Oliver, Jennifer W, Patel, Rupal, Multani, Pratik, Ladanyi, Marc, Drilon, Alexander

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Human cancers converge at the HIF-2α oncogenic axis von Franovic, Aleksandra, Holterman, Chet E, Payette, Josianne, Lee, Stephen

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MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment von Wilson, RaeAnna, Espinosa-Diez, Cristina, Kanner, Nathan, Chatterjee, Namita, Ruhl, Rebecca, Hipfinger, Christina, Advani, Sunil J., Li, Jie, Khan, Omar F., Franovic, Aleksandra, Weis, Sara M., Kumar, Sushil, Coussens, Lisa M., Anderson, Daniel G., Chen, Clark C., Cheresh, David A., Anand, Sudarshan

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DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia von Lachance, Gabriel, Uniacke, James, Audas, Timothy E., Holterman, Chet E., Franovic, Aleksandra, Payette, Josianne, Lee, Stephen

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Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer von Smith, Karlene, Gunaratnam, Lakshman, Morley, Melissa, Franovic, Aleksandra, Mekhail, Karim, Lee, Stephen

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Detection of ERBB2 (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort von Lee, Jeeyun, Franovic, Aleksandra, Shiotsu, Yukimasa, Kim, Seung Tae, Kim, Kyoung-Mee, Banks, Kimberly C, Raymond, Victoria M, Lanman, Richard B

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An oxygen-regulated switch in the protein synthesis machinery von UNIACKE, James, HOLTERMAN, Chet E, LACHANCE, Gabriel, FRANOVIC, Aleksandra, JACOB, Mathieu D, FABIAN, Marc R, PAYETTE, Josianne, HOLCIK, Martin, PAUSE, Arnim, LEE, Stephen

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HIF-2α: Many cancers, one engine? von Franovic, Aleksandra, Lee, Stephen

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Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in Combination With Azacitidine for Newly Diagnosed Acute Myeloid Leukemia von DiNardo, Courtney D, Stein, Anthony S, Stein, Eytan M, Fathi, Amir T, Frankfurt, Olga, Schuh, Andre C, Döhner, Hartmut, Martinelli, Giovanni, Patel, Prapti A, Raffoux, Emmanuel, Tan, Peter, Zeidan, Amer M, de Botton, Stéphane, Kantarjian, Hagop M, Stone, Richard M, Frattini, Mark G, Lersch, Frederik, Gong, Jing, Gianolio, Diego A, Zhang, Vickie, Franovic, Aleksandra, Fan, Bin, Goldwasser, Meredith, Daigle, Scott, Choe, Sung, Wu, Bin, Winkler, Thomas, Vyas, Paresh

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Ivosidenib or enasidenib combined with intensive chemotherapy in patients with newly diagnosed AML: a phase 1 study von Stein, Eytan M., DiNardo, Courtney D., Fathi, Amir T., Mims, Alice S., Pratz, Keith W., Savona, Michael R., Stein, Anthony S., Stone, Richard M., Winer, Eric S., Seet, Christopher S., Döhner, Hartmut, Pollyea, Daniel A., McCloskey, James K., Odenike, Olatoyosi, Löwenberg, Bob, Ossenkoppele, Gert J., Patel, Prapti A., Roshal, Mikhail, Frattini, Mark G., Lersch, Frederik, Franovic, Aleksandra, Nabhan, Salah, Fan, Bin, Choe, Sung, Wang, Hongfang, Wu, Bin, Hua, Lei, Almon, Caroline, Cooper, Michael, Kantarjian, Hagop M., Tallman, Martin S.

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An oxygen-regulated switch in the protein synthesis machinery von Uniacke, James, Holterman, Chet E., Lachance, Gabriel, Franovic, Aleksandra, Jacob, Mathieu D., Fabian, Marc R., Payette, Josianne, Holcik, Martin, Pause, Arnim, Lee, Stephen

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The next-generation pan-RAF inhibitor, KIN-2787, is active in class II and class III BRAF mutant models von Franovic, Aleksandra, Miller, Nichol, Severson, Paul, Kanouni, Toufike, Timple, Noelito, Jiang, Ping, Murphy, Eric, Martin, Eric

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Design and rationale of a first-in-human (FIH) phase 1/1b study evaluating KIN-3248, a next-generation, irreversible (irrev), pan-FGFR inhibitor (FGFRi), in adult patients with sol... von Goyal, Lipika, Perez, Cesar Augusto, Kato, Shumei, Sharma, Manish, Garmezy, Benjamin, Kobayashi, Ken, Franovic, Aleksandra, Tam, Betty, Voong, Cynthia

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Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22–05): a single-arm, phase 1b–2 trial von Catenacci, Daniel V T, Kang, Yoon-Koo, Park, Haeseong, Uronis, Hope E, Lee, Keun-Wook, Ng, Matthew C H, Enzinger, Peter C, Park, Se Hoon, Gold, Philip J, Lacy, Jill, Hochster, Howard S, Oh, Sang Cheul, Kim, Yeul Hong, Marrone, Kristen A, Kelly, Ronan J, Juergens, Rosalyn A, Kim, Jong Gwang, Bendell, Johanna C, Alcindor, Thierry, Sym, Sun Jin, Song, Eun-Kee, Chee, Cheng Ean, Chao, Yee, Kim, Sunnie, Lockhart, A Craig, Knutson, Keith L, Yen, Jennifer, Franovic, Aleksandra, Nordstrom, Jeffrey L, Li, Daner, Wigginton, Jon, Davidson-Moncada, Jan K, Rosales, Minori Koshiji, Bang, Yung-Jue

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Integrin αvβ3 Drives Slug Activation and Stemness in the Pregnant and Neoplastic Mammary Gland von Desgrosellier, Jay S., Lesperance, Jacqueline, Seguin, Laetitia, Gozo, Maricel, Kato, Shumei, Franovic, Aleksandra, Yebra, Mayra, Shattil, Sanford J., Cheresh, David A.

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Activity of KIN-3248, a next-generation pan-FGFR inhibitor, against acquired FGFR-gatekeeper and molecular-brake drug resistance mutations von Franovic, Aleksandra, Mohan, Adithi, Uryu, Sean, Wu, Qibiao, Jiang, Ping, Miller, Nichol, Tyhonas, John, Timple, Noelito, Severson, Paul, Kania, Robert, Murphy, Eric, Bardeesy, Nabeel, Martin, Eric

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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations von Tyhonas, John S., Arnold, Lee D., Cox, Jason M., Franovic, Aleksandra, Gardiner, Elisabeth, Grandinetti, Kathryn, Kania, Robert, Kanouni, Toufike, Lardy, Matthew, Li, Chun, Martin, Eric S., Miller, Nichol, Mohan, Adithi, Murphy, Eric A., Perez, Michelle, Soroceanu, Liliana, Timple, Noel, Uryu, Sean, Womble, Scott, Kaldor, Stephen W.

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Glioblastomas require integrin αvβ3/PAK4 signaling to escape senescence von Franovic, Aleksandra, Elliott, Kathryn C, Seguin, Laetitia, Camargo, M Fernanda, Weis, Sara M, Cheresh, David A

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Abstract LB-493: Blocking the integrin αvβ3-CRAF axis with Cilengitide arrests glioblastoma cells in pro-metaphase von Franovic, Aleksandra, Cheresh, David A.

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