Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma von Schäfer, Alexander, Haenig, Benedicte, Erupathil, Julie, Strickner, Panja, Sabato, Daniela, Welford, Richard W. D., Klaeylé, Lhéanna, Simon, Elise, Krepler, Clemens, Brafford, Patricia, Xiao, Min, Herlyn, Meenhard, Gstaiger, Matthias, Lehembre, Francois, Renz, Imke

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NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin von Lehembre, Francois, Yilmaz, Mahmut, Wicki, Andreas, Schomber, Tibor, Strittmatter, Karin, Ziegler, Dominik, Kren, Angelika, Went, Phillip, Derksen, Patrick WB, Berns, Anton, Jonkers, Jos, Christofori, Gerhard

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Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice von Kim, Sun-Jin, Lee, Ho Jeong, Kim, Mark Seungwook, Choi, Hyun Jin, He, Junqin, Wu, Qiuyu, Aldape, Kenneth, Weinberg, Jeffrey S, Yung, W K Alfred, Conrad, Charles A, Langley, Robert R, Lehembre, François, Regenass, Urs, Fidler, Isaiah J

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Discovery of the Potent, Selective, Orally Available CXCR7 Antagonist ACT-1004-1239 von Richard-Bildstein, Sylvia, Aissaoui, Hamed, Pothier, Julien, Schäfer, Gabriel, Gnerre, Carmela, Lindenberg, Eleanor, Lehembre, François, Pouzol, Laetitia, Guerry, Philippe

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Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data von Schäfer, Alexander, Gjerga, Enio, Welford, Richard WD, Renz, Imke, Lehembre, Francois, Groenen, Peter MA, Saez‐Rodriguez, Julio, Aebersold, Ruedi, Gstaiger, Matthias

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Distinct mechanisms of tumor invasion and metastasis von Yilmaz, Mahmut, Christofori, Gerhard, Lehembre, François

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Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail von Grotegut, Stefan, von Schweinitz, Dietrich, Christofori, Gerhard, Lehembre, François

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Macitentan (ACT-064992), a Tissue-Targeting Endothelin Receptor Antagonist, Enhances Therapeutic Efficacy of Paclitaxel by Modulating Survival Pathways in Orthotopic Models of Meta... von Kim, Sun-Jin, Kim, Jang Seong, Kim, Seung Wook, Brantley, Emily, Yun, Seok Joong, He, Junqin, Maya, Marva, Zhang, Fahao, Wu, Qiuyu, Lehembre, François, Regenass, Urs, Fidler, Isaiah J

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The SUMO Pathway Is Essential for Nuclear Integrity and Chromosome Segregation in Mice von Nacerddine, Karim, Lehembre, François, Bhaumik, Mantu, Artus, Jérôme, Cohen-Tannoudji, Michel, Babinet, Charles, Pandolfi, Pier Paolo, Dejean, Anne

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CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis von Pouzol, Laetitia, Sassi, Anna, Baumlin, Nadège, Tunis, Mélanie, Strasser, Daniel S., Lehembre, François, Martinic, Marianne M.

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Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton von Wicki, Andreas, Lehembre, François, Wick, Nikolaus, Hantusch, Brigitte, Kerjaschki, Dontscho, Christofori, Gerhard

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Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors von Corminboeuf, Olivier, Diethelm, Stefan, Zumbrunn, Cornelia, Lyothier, Isabelle, Niggli, Nadja, Gnerre, Carmela, Jeay, Sébastien, Lehembre, François, Boss, Christoph

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Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel von Lee, Ho Jeong, Hanibuchi, Masaki, Kim, Sun-Jin, Yu, Hyunkyung, Kim, Mark Seungwook, He, Junqin, Langley, Robert R, Lehembre, François, Regenass, Urs, Fidler, Isaiah J

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Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis von Yilmaz, Mahmut, Maaß, Dorothea, Tiwari, Neha, Waldmeier, Lorenz, Schmidt, Petra, Lehembre, François, Christofori, Gerhard

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Metastatic disease: A drug discovery perspective von Lehembre, François, Regenass, Urs

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A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor von Lotz-Jenne, Carina, Lüthi, Urs, Ackerknecht, Sabine, Lehembre, François, Fink, Tobias, Stritt, Manuel, Wirth, Matthias, Pavan, Simona, Bill, Ruben, Regenass, Urs, Christofori, Gerhard, Meyer-Schaller, Nathalie

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Increased tumor cell dissemination and cellular senescence in the absence of β1-integrin function von Kren, Angelika, Baeriswyl, Vanessa, Lehembre, François, Wunderlin, Christoph, Strittmatter, Karin, Antoniadis, Helena, Fässler, Reinhard, Cavallaro, Ugo, Christofori, Gerhard

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Antivascular Therapy for Multidrug-Resistant Ovarian Tumors by Macitentan, a Dual Endothelin Receptor Antagonist von Kim, Sun-Jin, Kim, Jang Seong, Kim, Seung Wook, Yun, Seok Joong, He, Junqin, Brantley, Emily, Fan, Dominic, Strickner, Panja, Lehembre, François, Regenass, Urs, Fidler, Isaiah J

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Regulation of Pax3 transcriptional activity by SUMO-1-modified PML von LEHEMBRE, Francois, MÜLLER, Stefan, PANDOLFI, Pier Paolo, DEJEAN, Anne

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Abstract 1809: ACT-1002-4391 - A novel potent antagonist of the prostaglandin E2 receptors EP2 and EP4 with excellent duality von Jeay, Sébastien, Diethelm, Stefan, Knopf, Agnes, Goxe, Marie, Daugan, Marie, Erupathil, Julie, Pothier, Julien, Pozzi, Davide, Sifferlen, Thierry, Wyder, Lorenza, Lyothier, Isabelle, Corminboeuf, Olivier, Lehembre, Francois, Renz, Imke, Meyer, Dominique

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